US-12617773-B2 - Azetidin-3-ylmethanol derivatives as CCR6 receptor modulators

Abstract

The present invention relates to compounds of Formula (I), their synthesis and use as CCR6 receptor modulators for the treatment or prevention of various diseases, conditions or disorders.

Inventors

• Oliver ALLEMANN
• Eva Caroff
• Alexia CHAVANTON-ARPEL
• Andrew CROXFORD
• Francis Hubler
• Loïc JACOB
• Emmanuel Meyer
• Sylvia Richard-Bildstein

Assignees

• IDORSIA PHARMACEUTICALS LTD

Dates

Publication Date

20260505

Application Date

20210430

Priority Date

20200430

Claims (20)

1. 1 . A compound according to Formula (I) wherein A represents a 6-membered heteroaryl containing from one to three ring nitrogen atom(s), wherein said 6-membered heteroaryl is unsubstituted, mono-, di- or tri-substituted, wherein the substituent(s), if any, is(are) independently selected from halogen; cyano; hydroxy-C 1-6 -alkyl which is optionally substituted with one to three fluorine atoms; C 1-5 -alkyl which is unsubstituted or mono-substituted with C 1-3 -alkoxy; C 3-6 -cycloalkyl which is optionally fused with a pyridine ring, wherein said C 3-6 -cycloalkyl is unsubstituted or mono-substituted with hydroxy; —O—R O1 , wherein R O1 represents C 3-6 -cycloalkyl or pyrrolidinyl which is independently unsubstituted or mono-substituted with C 1-3 -alkyl or C 1-4 -alkyl-carbonyl; phenyl-L 1 -, wherein said phenyl is unsubstituted or mono-substituted with fluorine, C 1-4 -alkoxy-carbonyl, or hydroxy-C 1-4 -alkyl; wherein -L 1 - represents a bond, oxygen, or the group —CH 2 —O—; C 4-6 -heterocyclyl containing one or two ring heteroatoms independently selected from nitrogen and oxygen, wherein said C 4-6 -heterocyclyl is unsubstituted, mono-, or di-substituted with oxo, hydroxy, C 1-3 -alkyl, C 1-4 -alkyl-carbonyl, or C 1-4 -alkoxy-carbonyl; 5-membered heteroaryl containing one or two ring nitrogen atoms, wherein said 5-membered heteroaryl is unsubstituted or mono-substituted with C 1-3 -alkyl; indolyl; pyrrolopyridinyl; N—(C 1-3 -alkyl)-amino-carbonyl-oxy; or 1-hydroxy-1-C 3-5 -cycloalkyl-1-(pyridinyl)-methyl; C 3-5 -alkyl which is substituted with hydroxy and R A1 , wherein said substituents are both at position 3 with respect to the point of attachment of said C 3-5 -alkyl to the rest of the molecule; wherein R A1 represents tetrahydropyranyl; phenyl which is unsubstituted or mono-substituted with fluorine or C 1-3 -alkoxy; 5- or 6-membered heteroaryl containing one or two ring heteroatom(s) being independently selected from nitrogen or sulfur, wherein said 5- or 6-membered heteroaryl is independently unsubstituted, mono- or di-substituted, and wherein the substituent(s), if any, is(are) independently selected from C 1-3 -alkyl, C 3-5 -cycloalkyl, or C 1-3 -alkoxy; or indazolyl; C 3-5 -alkenyl which is unsubstituted or mono-substituted with hydroxy; C 4-6 -cycloalkenyl which is unsubstituted, mono-, or di-substituted with C 1-3 -alkyl, oxo, or hydroxy, wherein optionally one ring carbon atom of said C 4-6 -cycloalkenyl is replaced by an oxygen atom; C 3-6 -cycloalkyl which is unsubstituted, mono-, or di-substituted with C 1-3 -alkyl, hydroxy, or hydroxy-C 1-3 -alkyl, wherein optionally one ring carbon atom of said C 3-6 -cycloalkyl is replaced by an oxygen atom; —O—RO 2 , wherein RO 2 represents C 1-4 -alkyl; C 2-5 -alkyl which is mono-substituted with hydroxy or C 1-3 -alkoxy; -L 2 -CY 2 , wherein L 2 - independently represents a bond, —CH 2 —, or —CH 2 —CH 2 —; and CY 2 independently represents phenyl which is unsubstituted or mono-substituted with hydroxy-C 1-3 -alkyl; benzyl-oxy; 5- to 6-membered heteroaryl containing one to three ring heteroatom(s) being independently selected from nitrogen, oxygen, or sulfur, wherein said 5- or 6-membered heteroaryl is independently unsubstituted, mono- or di-substituted; wherein the substituent(s), if any, is(are) independently selected from C 1-3 -alkyl or C 1-3 -cycloalkyl; C 3-6 -cycloalkyl, wherein optionally one carbon ring atom is replaced by one heteroatom selected from oxygen and nitrogen; wherein said C 3-6 -cycloalkyl is unsubstituted, mono-, or di-substituted, wherein the substituents are selected from C 1-3 -alkyl, hydroxy, fluoro, oxo, C 1-3 -alkyl-carbonyl and C 1-3 -alkoxy; benzooxazolonyl; or chromanyl; —C≡C—R T1 , wherein R T1 represents C 1-4 -alkyl, wherein said C 1-4 -alkyl independently is mono-substituted with hydroxy; C 1-3 -alkoxy; -S(═O) 2 —R SOT , wherein R SOT represents C 1-3 -alkyl, C 1-3 -alkyl-amino, or C 3-5 -cycloalkyl; -NR NT1 R NT2 wherein R NT1 represents hydrogen and R NT2 represents C 1-3 -alkyl-carbonyl, C 1-3 -alkoxy-C 1-3 -alkyl-carbonyl, or C 3-5 -cycloalkyl-carbonyl; C 4-6 -heterocyclyl containing one or two ring heteroatom(s) independently selected from nitrogen and oxygen; wherein said C 4-6 -heterocyclyl is mono-substituted with oxo; or di-substituted with oxo and one C 1-3 -alkyl; or N—(C 1-3 -alkyl-carbonyl)-piperidinyl-C 1-3 -alkyl; C 1-4 -alkyl which is di-substituted, wherein one substituent is hydroxy, and a second substituent is trifluoromethyl; C 3-6 -cycloalkyl which is mono-substituted with hydroxy; amino-sulfonyl which is optionally di-substituted with methyl; phenyl which is mono-substituted with halogen; pyridinyl; pyrimidinyl which is mono-substituted with C 1-3 -alkyl; or oxazolidinonyl; C 3-6 -cycloalkyl fused with a pyridine ring, wherein said C 3-6 -cycloalkyl is mono-substituted with hydroxy; wherein optionally one ring carbon atom in said C 3-6 -cycloalkyl is replaced by one oxygen atom; C 4-6 -heterocyclyl containing one ring heteroatom independently selected from nitrogen and oxygen; wherein said C 4-6 -heterocyclyl is mono-, di-, or tri-substituted, wherein the substituent(s) is(are) independently selected from C 1-3 -alkyl, hydroxy, oxo, C 1-3 -alkyl-carbonyl, C 1-3 -alkoxy-carbonyl, C 1-3 -alkyl-sulfonyl, and C 1-3 -alkyl-amino-sulfonyl; pyrazolyl which is N-substituted with methyl; indolyl; 3-hydroxy-1-methyl-1,3-dihydro-indol-2-on-3-yl; or 4-hydroxy-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl; —C≡C—C(OH)(R T2 )(R T3 ), wherein R T2 represents hydrogen or C 1-3 -alkyl; R T3 represents phenyl which is unsubstituted or mono-substituted, wherein the substituent, if any, is selected from C 1-3 -alkoxy and halogen; 5- to 6-membered heteroaryl containing one or two ring heteroatom(s) being independently selected from nitrogen, oxygen, or sulfur; wherein said 5- or 6-membered heteroaryl is independently unsubstituted, mono- or di-substituted, and wherein the substituent(s), if any, is(are) independently selected from C 1-3 -alkyl, C 1-3 -cycloalkyl, C 1-3 -fluoroalkyl, and C 1-3 -alkoxy; C 4-7 -heterocyclyl containing one ring heteroatom selected from nitrogen and oxygen; wherein said C 4-7 -heterocyclyl is unsubstituted, mono-, or di-substituted, wherein the substituent(s), if any, is(are) independently selected from C 1-3 -alkyl or C 1-3 -alkyl-carbonyl; or indazolyl; —NR N3 R N4 wherein R N3 represents C 1-3 -alkyl; and R N4 represents hydroxy-C 1-3 -alkyl or 2-(benzyl-oxy)-C 1-3 -alkyl; or R N3 and R N4 form, together with the nitrogen to which they are attached, a heterocyclic ring of 4 to 6 members, wherein the members needed to complete said heterocyclic ring are each independently selected from —CH 2 —, —O—, —(C=O)—, —CHR X — and —C(R Y ) 2 —; wherein said heterocyclic ring does not contain more than one member independently selected from the group consisting of —O— and —(C=O)—; wherein said heterocyclic ring does not contain more than two members selected from the group consisting of —CHR X —; and wherein said heterocyclic ring does not contain more than two members selected from the group consisting of —C(R Y ) 2 —; wherein R X independently represents fluorine, methyl, isopropyl, isobutyl, tert-butyl, hydroxy, trifluoromethyl, hydroxy-methyl, 1-hydroxy-ethyl, 1-hydroxy-1-methyl-ethyl, cyclopropyl, 2-methoxy-ethyl, 2-methyl-thiazol-5-yl, 4-methyl-thiazol-2-yl, phenyl, benzyl, tetrahydropyran-4-yl, N-acetyl-piperidin-4-yl, 1,2,4-oxadiazolyl, 3-methyl-1,2,4-oxadiazol-5-yl, 2-methyl-2H-[1,2,3]triazol-4-yl, 1-methyl-1H-pyrazol-4-yl, 1-difluoromethyl-1H-pyrazol-4-yl, 1,3-dimethyl-1H-pyrazol-4-yl, pyridin-2-yl, 6-methyl-pyridin-3-yl, 6-isopropyl-pyridin-2-yl, 6-trifluoromethyl-pyridin-3-yl, 2-isopropyl-pyrimidin-4-yl, or 1-methoxy-methyl; and wherein R Y independently represents fluorine, hydroxy, cyclopropyl, methyl, hydroxy-methyl, or trifluoromethyl; —(C=O)—N(R N5 )(R N6 ), wherein R N5 represents hydrogen; and R N6 represents C 3-6 -cycloalkyl or tetrahydropyranyl; or R N5 and R N6 form, together with the nitrogen to which they are attached, pyrrolidinyl; piperidin-4-yl or pyrrolidin-3-yl which are mono-substituted at the nitrogen ring atom, wherein the substituent independently is selected from C 1-4 -alkoxy-carbonyl, pyridinyl, phenyl, and 4-methylphenyl-sulfonyl; 5- or 6-membered heteroaryl containing from one to three ring heteroatom(s) independently selected from nitrogen, oxygen and sulfur; wherein said 5- or 6-membered heteroaryl is independently unsubstituted, mono-, di-, or tri-substituted, wherein the substituent(s), if any, is(are) independently selected from C 1-4 -alkyl which is unsubstituted; mono-substituted with hydroxy; C 1-4 -alkoxy; or -N(R N7 )(R N8 ), wherein R N7 represents hydrogen or C 1-3 -alkyl; and R N8 independently represent C 3-5 -cycloalkyl-carbonyl, C 1-3 -alkyl, C 1-3 -alkyl-carbonyl including deuterated C 1-3 -alkyl-carbonyl, C 1-3 -alkoxy-C 1-3 -alkyl-carbonyl, tetrahydropyranyl-carbonyl, or hydroxy-C 1-3 -alkyl-carbonyl; di-substituted, wherein one substituent is hydroxy, and another substituent is trifluoromethyl; or two substituents are hydroxy; or di- or tri-substituted, wherein two substituents are fluorine and, if present, one substituent is hydroxy; -L 3 -CY 3 , wherein -L 3 - independently represents a bond, —CH 2 —, —CH 2 —CH 2 —, —C(CH 3 ) 2 —, —CH(OH)—, or —O—CH 2 —, wherein when -L 3 - is —O—CH 2 —, said CY 3 is attached to the oxygen atom of said —O—CH 2 —; and CY 3 independently represents C 4-6 -heterocyclyl, said C 4-6 -heterocyclyl containing one or two ring heteroatoms independently selected from nitrogen and oxygen; wherein said CY 3 independently is unsubstituted, mono-, di-, or tri-substituted, wherein the substituents are independently selected from halogen; oxo; hydroxy; C 1-3 -alkyl which is optionally mono-substituted with C 1-3 -alkoxy; C 1-3 -alkoxy; -(C=O)—R CO , wherein R CO represents C 1-3 -alkyl which is optionally mono-substituted with hydroxy or C 1-3 -alkoxy; C 1-3 -fluoroalkyl; C 1-3 -alkoxy, wherein said C 1-3 -alkoxy is optionally mono-substituted with C 1-3 -alkoxy; C 3-6 -cycloalkyl-(CH 2 )n-, wherein optionally one or two carbon ring atom(s) is/are replaced by one or two oxygen ring atom(s); wherein n represents the integer 0, 1, or 2; or phenyl; -N(R N9 )(R N10 ), wherein R N9 represents hydrogen or C 1-3 -alkyl; and R N10 represents C 1-3 -alkyl, C 1-3 -alkyl-carbonyl, C 1-3 -alkyl-sulfonyl, C 1-3 -alkoxy-carbonyl, C 1-3 -alkoxy-C 1-3 -alkyl-carbonyl, or tetrahydropyranyl-carbonyl; -S(═O) 2 —R SO , wherein R SO represents C 1-3 -alkyl which is optionally mono-substituted with hydroxy, C 1-3 -alkoxy, or amino; or C 3-5 -cycloalkyl, wherein optionally one carbon ring atom is replaced by one oxygen ring atom; 5-membered heteroaryl containing one ring heteroatom selected from nitrogen, oxygen, and sulfur; wherein said 5-membered heteroaryl is unsubstituted; and phenyl-(CH 2 ) p —, wherein p represents the integer 0, 1, or 2; phenyl or 6-membered heteroaryl containing one or two ring nitrogen atom(s); wherein said phenyl or 6-membered heteroaryl is independently unsubstituted or mono-substituted with C 1-3 -alkyl or C 1-3 -alkoxy; pyrazolyl-C 1-3 -alkyl; C 1-3 -alkyl-sulfonyl-C 1-3 -alkyl; 3-hydroxymethyl-bicyclo[1.1.1]pent-1-yl; 7-oxa-bicyclo[2.2.1]hept-2-yl; and 6-oxa-spiro[2.5]oct-1-yl; 5-oxo-4-oxa-6-azaspiro[2.4]hept-6-yl, 5-aza-spiro[2.4]heptan-6-on-5yl, 2,2-dimethyl-6-oxo-5-oxa-7-azaspiro[3.4]oct-7-yl, 2-cyclopropyl-6-oxo-5-oxa-7-azaspiro[3.4]oct-7-yl, 2-oxo-1-oxa-3-azaspiro[4.4]non-3-yl, 8,8-difluoro-2-oxo-1-oxa-3-azaspiro[4.5]dec-3-yl, or 8-oxo-7-oxa-9-azadispiro[3.1.4.1]undec-9-yl; 7-aza-bicyclo[2.2.1]hept-7-yl, 2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl, 6-oxa-3-aza-bicyclo[3.1.1]hept-3-yl, or 8-oxa-3-azabicyclo[3.2.1]oct-3-yl; 5-oxo-6-azaspiro[3.4]oct-6-yl, 3-oxo-2-azaspiro[4.4]non-2-yl, 1-oxa-3-aza-spiro[4.5]decan-2-on-3-yl, 1-oxo-2-azaspiro[4.5]dec-2-yl, 1-oxo-8-oxa-2-azaspiro[4.5]dec-2-yl, 3-oxo-8-oxa-2-azaspiro[4.5]dec-2-yl, or 4-oxo-hexahydro-5H-furo[2,3-c]pyrrol-5-yl; 3-(7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl)propyl or 3-(8-hydroxy-5,6,7,8-tetrahydroquinolin-8-yl)propyl); 6-acetyl-5,6,7,8-tetrahydro-1,6-naphthyridine-2-yl; 2-(6,7-dihydro-5H-[1]pyrindin-7-ol)-ethyl; 2-(8-hydroxy-5,6,7,8-tetrahydro-quinolin-8-yl)-ethyl; 2,3-dihydro-isoindol-1-on-2-yl; and 6-acetyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-2-yl; B represents phenyl, which is unsubstituted, mono-, di- or tri-substituted, wherein a first substituent, if present, is selected from halogen; C 1-5 -alkyl; C 2-4 -alkenyl; C 1-3 -alkoxy; C 1-3 -alkoxy-C 1-4 -alkyl; C 1-4 -fluoroalkyl; C 3-5 -cycloalkyl which independently is unsubstituted or mono-substituted with C 1-3 -alkyl or C 1-3 -fluoroalkyl; —SF 5 ; bicyclo[1.1.1]pent-1-yl; C 3-5 -cycloalkoxy; and C 1-3 -fluoroalkoxy; and the remaining substituent/s of B, if present, independently is/are selected from halogen and C 1-3 -alkyl; or B represents benzothiophenyl or naphthalenyl; R 1 represents C 1-3 -alkyl, cyano, or halogen; and R 2 represents C 1-4 -alkyl, C 3-5 -cycloalkyl, C 3-5 -cycloalkyl-C 1-3 -alkyl, hydroxy-C 1-3 -alkyl, C 1-3 -alkoxy-C 1-3 -alkyl, or C 1-3 -fluoroalkyl; or a pharmaceutically acceptable salt thereof.
2. 2 . A compound according to claim 1 , wherein A represents pyridin-3-yl, wherein A is mono-substituted in meta-position of A with respect to the point of attachment of A to the rest of the molecule, wherein the substituent is as defined in claim 1 ; or a pharmaceutically acceptable salt thereof.
3. 3 . A compound according to claim 1 , wherein said substituent of A or at least one of said substituents of A is 5- or 6-membered heteroaryl as defined in claim 1 , wherein the substituent(s) of said 5- or 6-membered heteroaryl, if any, is(are) independently selected from the optionally substituted C 1-4 -alkyl as defined in claim 1 ; or a pharmaceutically acceptable salt thereof.
4. 4 . A compound according to claim 3 , wherein said substituent of A or at least one of said substituents of A is 5- or 6-membered heteroaryl containing from one to three ring heteroatom(s) independently selected from nitrogen, oxygen and sulfur; wherein said 5- or 6-membered heteroaryl is independently unsubstituted, mono-, di-, or tri-substituted, wherein the substituent(s), if any, is(are) independently selected from C 1-4 -alkyl which is unsubstituted; mono-substituted with hydroxy; or C 1-4 -alkoxy; di-substituted, wherein one substituent is hydroxy, and another substituent is trifluoromethyl; or two substituents are hydroxy; or di- or tri-substituted, wherein two substituents are fluorine and, if present, one substituent is hydroxy; or a pharmaceutically acceptable salt thereof.
5. 5 . A compound according to claim 3 , wherein said substituent of A or at least one of said substituents of A is 1,2,4-oxadiazol-5-yl or 1,2,4-oxadiazol-3-yl, wherein said oxadiazolyl groups are mono-substituted, wherein the substituent is independently selected from C 1-4 -alkyl which is mono-substituted with hydroxy or C 1-4 -alkoxy; or a pharmaceutically acceptable salt thereof.
6. 6 . A compound according to claim 1 , wherein B represents phenyl, which is mono-, di- or tri-substituted, wherein a first substituent is attached in para-position with respect to the point of attachment of B to the rest of molecule, wherein said substituent is selected from C 1-5 -alkyl; C 1-3 -alkoxy-C 1-4 -alkyl; C 1-2 -fluoroalkyl; C 3-5 -cycloalkyl which is unsubstituted or mono-substituted with C 1-3 -alkyl or C 1-3 -fluoroalkyl; and C 1 -fluoroalkoxy; and the remaining substituent(s) of B, if present, independently is/are selected from halogen; or a pharmaceutically acceptable salt thereof.
7. 7 . A compound according to claim 1 , wherein R 1 represents methyl; or a pharmaceutically acceptable salt thereof.
8. 8 . A compound according to claim 1 , wherein R 2 represents C 1-4 -alkyl, C 3-5 -cycloalkyl, C 3-5 -cycloalkyl-C 1-3 -alkyl, or C 1-3 -fluoroalkyl; or a pharmaceutically acceptable salt thereof.
9. 9 . A compound according to claim 1 , which is also a compound of Formula (II) or a pharmaceutically acceptable salt thereof.
10. 10 . A compound according to claim 1 which is: (3-Fluoro-1-methyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol; 3-[Hydroxy-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methyl]-1-methyl-azetidine-3-carbonitrile; (R)-(1-Ethyl-3-methyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol; (R)-(3-Methyl-1-propyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol; (R)-(1-Isopropyl-3-methyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol; (R)-(1-Cyclopropylmethyl-3-methyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol; (R)-(1-Cyclobutyl-3-methyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol; (R)-(1-Isobutyl-3-methyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol; (R)-(1-Cyclopropyl-3-methyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol; (R)-[1-(2-Fluoro-ethyl)-3-methyl-azetidin-3-yl]-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol; (R)-[1-(2,2-Difluoro-ethyl)-3-methyl-azetidin-3-yl]-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol; (R)-(1-tert-Butyl-3-methyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol; (1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(3-methoxy-prop-1-ynyl)-pyridin-3-yl]-methanol; 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-prop-1-yn-1-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-methyl-but-3-yn-2-ol; (R)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-but-3-yn-2-ol; (S)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-but-3-yn-2-ol; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-cyclopentanol; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-cyclopropanol; 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-3-hydroxy-azetidine-1-carboxylic acid tert-butyl ester; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-cyclobutanol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-but-3-yn-1-ol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(1-methyl-1H-pyrazol-4-ylethynyl)-pyridin-3-yl]-methanol; 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-phenyl-prop-2-yn-1-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-phenyl-but-3-yn-2-ol; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-methyl-pent-1-yn-3-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-tetrahydro-pyran-4-ol; 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-(tetrahydro-pyran-4-yl)-prop-2-yn-1-ol; 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-(1,3-dimethyl-1H-pyrazol-4-yl)-prop-2-yn-1-ol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(tetrahydro-pyran-4-ylethynyl)-pyridin-3-yl]-methanol; 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-(2-methyl-thiazol-4-yl)-prop-2-yn-1-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(3-fluoro-phenyl)-but-3-yn-2-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(4-methoxy-phenyl)-but-3-yn-2-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methoxy-phenyl)-but-3-yn-2-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1-methyl-1H-pyrazol-3-yl)-but-3-yn-2-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methyl-thiazol-4-yl)-but-3-yn-2-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methoxy-pyridin-2-yl)-but-3-yn-2-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-pyrimidin-2-yl-but-3-yn-2-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1,5-dimethyl-1H-pyrazol-3-yl)-but-3-yn-2-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl-pyrimidin-4-yl)-but-3-yn-2-ol; 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-(1,5-dimethyl-1H-pyrazol-3-yl)-prop-2-yn-1-ol; 8-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-5,6,7,8-tetrahydro-quinolin-8-ol; 7-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-6,7-dihydro-5H-[1]pyrindin-7-ol; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-3-pyridin-2-yl-pent-1-yn-3-ol; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-3-(6-methoxy-pyridin-2-yl)-pent-1-yn-3-ol; 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-3-hydroxy-azetidin-1-yl)-2-methyl-propan-1-one; (R)-(1,3-Dimethyl-azetidin-3-yl)-[5-(1H-indol-2-ylethynyl)-pyridin-3-yl]-(4-isopropyl-phenyl)-methanol; (1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(3-methoxy-propyl)-pyridin-3-yl]-methanol; 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-propan-1-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-methyl-butan-2-ol; (S)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-butan-2-ol; (R)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-butan-2-ol; 1-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-ethyl)-cyclopentanol; 1-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-ethyl)-cyclopropanol; 3-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-ethyl)-3-hydroxy-azetidine-1-carboxylic acid tert-butyl ester; 1-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-ethyl)-cyclobutanol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-butan-1-ol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[2-(1-methyl-1H-pyrazol-4-yl)-ethyl]-pyridin-3-yl}-methanol; 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-phenyl-propan-1-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-phenyl-butan-2-ol; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-methyl-pentan-3-ol; 4-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-ethyl)-tetrahydro-pyran-4-ol; 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-(tetrahydro-pyran-4-yl)-propan-1-ol; 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-(1,3-dimethyl-1H-pyrazol-4-yl)-propan-1-ol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[2-(tetrahydro-pyran-4-yl)-ethyl]-pyridin-3-yl}-methanol; 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-(2-methyl-thiazol-4-yl)-propan-1-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(3-fluoro-phenyl)-butan-2-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(4-methoxy-phenyl)-butan-2-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methoxy-phenyl)-butan-2-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1-methyl-1H-pyrazol-3-yl)-butan-2-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methyl-thiazol-4-yl)-butan-2-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methoxy-pyridin-2-yl)-butan-2-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-pyrimidin-2-yl-butan-2-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1,5-dimethyl-1H-pyrazol-3-yl)-butan-2-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl-pyrimidin-4-yl)-butan-2-ol; 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-(1,5-dimethyl-1H-pyrazol-3-yl)-propan-1-ol; 8-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-ethyl)-5,6,7,8-tetrahydro-quinolin-8-ol; 7-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-ethyl)-6,7-dihydro-5H-[1]pyrindin-7-ol; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-3-pyridin-2-yl-pentan-3-ol; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-3-(6-methoxy-pyridin-2-yl)-pentan-3-ol; (R)-(1,3-Dimethyl-azetidin-3-yl)-{5-[2-(1H-indol-2-yl)-ethyl]-pyridin-3-yl}-(4-isopropyl-phenyl)-methanol; (R)-(4-Cyclopropyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-{5-[3-(tetrahydro-pyran-4-yl)-[1,2,4]oxadiazol-5-yl]-pyridin-3-yl}-methanol; (R)-(4-Cyclopropyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-{5-[3-(2-methoxy-1,1-dimethyl-ethyl)-[1,2,4]oxadiazol-5-yl]-pyridin-3-yl}-methanol; (R)-[5-(3-Cyclobutoxymethyl-[1,2,4]oxadiazol-5-yl)-pyridin-3-yl]-(4-cyclopropyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-propyl-phenyl)-{5-[3-(tetrahydro-pyran-4-yloxymethyl)-[1,2,4]oxadiazol-5-yl]-pyridin-3-yl}-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-propyl-phenyl)-{5-[3-(tetrahydro-pyran-4-yl)-[1,2,4]oxadiazol-5-yl]-pyridin-3-yl}-methanol; (R)-[5-(3-Cyclobutoxymethyl-[1,2,4]oxadiazol-5-yl)-pyridin-3-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-propyl-phenyl)-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[3-(tetrahydro-pyran-4-yl)-[1,2,4]oxadiazol-5-yl]-pyridin-3-yl}-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(3-morpholin-4-ylmethyl-[1,2,4]oxadiazol-5-yl)-pyridin-3-yl]-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-{5-[3-(2,6-dimethyl-morpholin-4-ylmethyl)-[1,2,4]oxadiazol-5-yl]-pyridin-3-yl}-(4-isopropyl-phenyl)-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[3-(4-methyl-tetrahydro-pyran-4-yl)-[1,2,4]oxadiazol-5-yl]-pyridin-3-yl}-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[(1S,2S,4R)-3-(7-oxa-bicyclo[2.2.1]hept-2-yl)-[1,2,4]oxadiazol-5-yl]-pyridin-3-yl}-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[3-(tetrahydro-pyran-4-yloxymethyl)-[1,2,4]oxadiazol-5-yl]-pyridin-3-yl}-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(3-morpholin-4-yl-[1,2,4]oxadiazol-5-yl)-pyridin-3-yl]-methanol; (R)-(4-Cyclopropyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-{5-[3-(4-methoxy-tetrahydro-pyran-4-yl)-[1,2,4]oxadiazol-5-yl]-pyridin-3-yl}-methanol; (R)-(4-Cyclopropyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-{5-[3-(3-hydroxymethyl-bicyclo[1.1.1]pent-1-yl)-[1,2,4]oxadiazol-5-yl]-pyridin-3-yl}-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-{5-[3-(3-hydroxymethyl-bicyclo[1.1.1]pent-1-yl)-[1,2,4]oxadiazol-5-yl]-pyridin-3-yl}-(4-isopropyl-phenyl)-methanol; 2-(5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-3-yl)-2-methyl-propan-1-ol; 2-(5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-3-yl)-propan-2-ol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[3-(1-methoxy-1-methyl-ethyl)-[1,2,4]oxadiazol-5-yl]-pyridin-3-yl}-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[3-(1-methoxy-cyclobutyl)-[1,2,4]oxadiazol-5-yl]-pyridin-3-yl}-methanol; 1-(5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-3-yl)-2-methyl-propan-2-ol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(5-methanesulfonylmethyl-[1,2,4]oxadiazol-3-yl)-pyridin-3-yl]-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(2-methoxy-ethyl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(5-methoxymethyl-[1,2,4]oxadiazol-3-yl)-pyridin-3-yl]-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(tetrahydro-furan-3-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(tetrahydro-pyran-4-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-methanol; 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-cyclohexanol; (R)-[5-(5-tert-Butoxymethyl-[1,2,4]oxadiazol-3-yl)-pyridin-3-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(tetrahydro-pyran-4-ylmethyl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-methanol; 4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-cyclohexanol; 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-ylmethyl)-cyclohexanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(1-methoxy-cyclobutyl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(6-oxa-spiro[2.5]oct-1-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(tetrahydro-pyran-3-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-{5-[1-(tetrahydro-furan-2-yl)methyl]-[1,2,4]oxadiazol-3-yl}-pyridin-3-yl)-methanol; (R)-2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1,1,1-trifluoro-propan-2-ol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(1-methoxy-1-methyl-ethyl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-methanol; (R)-{5-[5-((R)-Cyclohexyl-hydroxy-methyl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol; 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-cyclopropanol; 2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan-2-ol; 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-cyclopentanol; 3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-cyclobutanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-{5-[5-(4-fluoro-tetrahydro-pyran-4-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-(4-isopropyl-phenyl)-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-{5-[5-((2R,4R,6S)-2,6-dimethyl-tetrahydro-pyran-4-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-(4-isopropyl-phenyl)-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(tetrahydro-pyran-4-yloxymethyl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-{5-[1-methyl-1-(tetrahydro-pyran-4-yl)-ethyl]-[1,2,4]oxadiazol-3-yl}-pyridin-3-yl)-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-{5-[2-(tetrahydro-pyran-4-yl)-ethyl]-[1,2,4]oxadiazol-3-yl}-pyridin-3-yl)-methanol; 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-cyclobutanol; 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-2-methyl-propan-2-ol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(7-oxa-bicyclo[2.2.1]hept-2-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(4-methyl-tetrahydro-pyran-4-yloxymethyl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(5-oxetan-3-yl-[1,2,4]oxadiazol-3-yl)-pyridin-3-yl]-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(2-methoxy-1,1-dimethyl-ethyl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-methanol; 2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-2-methyl-propan-1-ol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(2-methoxy-2-methyl-propyl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-methanol; 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-ylmethyl)-cyclobutanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(1-methoxymethyl-cyclopropylmethyl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(2-pyrazol-1-yl-ethyl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-methanol; (R)—N-(2-(3-(5-((1,3-dimethylazetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1,2,4-oxadiazol-5-yl)ethyl)acetamide-2,2,2-d 3 ; (R)—N-(1-(3-(5-((1,3-dimethylazetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1,2,4-oxadiazol-5-yl)-2-methylpropan-2-yl)acetamide-2,2,2-d 3 ; 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-2-hydroxy-ethanone; (R)-1-(4-(3-(5-((1,3-dimethylazetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)ethan-1-one-2,2,2-d 3 ; N-[2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-ethyl]-2-hydroxy-N-methyl-acetamide; (R)—N-(2-(3-(5-((1,3-dimethylazetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1,2,4-oxadiazol-5-yl)ethyl)-N-methylacetamide-d 3 ; (1,3-Dimethyl-azetidin-3-yl)-(6-methoxy-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol; (1,3-Dimethyl-azetidin-3-yl)-(6-phenoxy-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol; (1,3-Dimethyl-azetidin-3-yl)-(6-ethoxy-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol; (1,3-Dimethyl-azetidin-3-yl)-(5-methyl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol; (1,3-Dimethyl-azetidin-3-yl)-(4-propyl-phenyl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol; (1,3-Dimethyl-azetidin-3-yl)-(4-methoxy-phenyl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol; (1,3-Dimethyl-azetidin-3-yl)-(4-ethyl-phenyl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol; (1,3-Dimethyl-azetidin-3-yl)-phenyl-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol; (4-Cyclobutyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol; (4-Cyclobutoxy-phenyl)-(1,3-dimethyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol; (1,3-Dimethyl-azetidin-3-yl)-(4-ethoxy-phenyl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol; (4-tert-Butyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol; (1,3-Dimethyl-azetidin-3-yl)-(4-isopropoxy-phenyl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol; (1,3-Dimethyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-methanol; (1,3-Dimethyl-azetidin-3-yl)-[4-(1-methyl-cyclopropyl)-phenyl]-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol; (4-Cyclopropoxy-phenyl)-(1,3-dimethyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol; (S)-[2-(3,3-Difluoro-pyrrolidin-1-yl)-pyridin-4-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol; (S)-[2-((3R,4S)-3,4-Difluoro-pyrrolidin-1-yl)-pyridin-4-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol; (S)-(1,3-Dimethyl-azetidin-3-yl)-(2-isobutoxy-pyridin-4-yl)-(4-isopropyl-phenyl)-methanol; 4-{4-[(S)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-2-yl}-2-methyl-butan-2-ol; (R)-[6-(3,3-Difluoro-pyrrolidin-1-yl)-pyridazin-4-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol; (S)-5-tert-Butyl-3-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-oxazolidin-2-one; (R)-1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-pyrrolidin-3-ol; (S)-1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-pyrrolidin-3-ol; (R)-(1,3-Dimethyl-azetidin-3-yl)-[5-((S)-3-hydroxymethyl-pyrrolidin-1-yl)-pyridin-3-yl]-(4-isopropyl-phenyl)-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol; (S)-1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-3-methyl-pyrrolidin-3-ol; 3-Cyclopropyl-1-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-pyrrolidin-3-ol; 2-((S)-1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-pyrrolidin-3-yl)-propan-2-ol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-morpholin-4-yl-pyridin-3-yl)-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(3,4,5,6-tetrahydro-2H-[1,3′]bipyridinyl-5′-yl)-methanol; (R)-[5-(7-Aza-bicyclo[2.2.1]hept-7-yl)-pyridin-3-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-((S)-2-methyl-pyrrolidin-1-yl)-pyridin-3-yl]-methanol; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-3-trifluoromethyl-pyrrolidin-3-ol; (R)-[5-(3,3-Difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol; 5′-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-3,4,5,6-tetrahydro-2H-[1,3′]bipyridinyl-4-ol; 5′-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-3,4,5,6-tetrahydro-2H-[1,3′]bipyridinyl-3-ol; (R)-{5-[(2-Benzyloxy-ethyl)-methyl-amino]-pyridin-3-yl}-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-[4-(1-methyl-cyclopropyl)-phenyl]-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol; (R)-[5-((3R,4S)-3,4-Difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-(1,3-dimethyl-azetidin-3-yl)-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-methanol; 2-[(S)-1-(5-{(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-methyl}-pyridin-3-yl)-pyrrolidin-3-yl]-propan-2-ol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-methanol; (R)-(4-tert-Butyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-(3,4,5,6-tetrahydro-2H-[1,3′]bipyridinyl-5′-yl)-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol; (R)-{5-[5-(1-Cyclopropanesulfonyl-piperidin-4-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol; 2-({5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-methyl-amino)-ethanol; (R)-1-((S)-1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-pyrrolidin-3-yl)-ethanol; 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-oxazolidin-2-one; 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-5-phenyl-oxazolidin-2-one; 5-Benzyl-3-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-oxazolidin-2-one; 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-5-isopropyl-oxazolidin-2-one; 6-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-oxa-6-aza-spiro[2.4]heptan-5-one; 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-oxa-3-aza-spiro[4.4]nonan-2-one; 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-5-(tetrahydro-pyran-4-yl)-oxazolidin-2-one; 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-5,5-dimethyl-oxazolidin-2-one; 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-8,8-difluoro-1-oxa-3-aza-spiro[4.5]decan-2-one; 9-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-7-oxa-9-aza-dispiro[3.1.4.1]undecan-8-one; 2-Cyclopropyl-7-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-5-oxa-7-aza-spiro[3.4]octan-6-one; 7-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2,2-dimethyl-5-oxa-7-aza-spiro[3.4]octan-6-one; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-phenyl-pyrrolidin-2-one; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-pyrrolidin-2-one; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-isopropyl-pyrrolidin-2-one; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-3-isopropyl-pyrrolidin-2-one; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4,4-dimethyl-pyrrolidin-2-one; 5-(5-((R)-(1,3-Dimethyl-azetidin-3-yl)(hydroxy)(4-isopropyl-phenyl)methyl)pyridin-3-yl)hexahydro-4H-furo[2,3-c]pyrrol-4-one; 2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-aza-spiro[4.4]nonan-3-one; 6-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-6-aza-spiro[3.4]octan-5-one; 2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-8-oxa-2-aza-spiro[4.5]decan-3-one; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-3-(tetrahydro-pyran-4-yl)-pyrrolidin-2-one; 2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-aza-spiro[4.5]decan-1-one; 2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-8-oxa-2-aza-spiro[4.5]decan-1-one; (S)-1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-isobutyl-pyrrolidin-2-one; 4-Cyclopropyl-1-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-pyrrolidin-2-one; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-trifluoromethyl-pyrrolidin-2-one; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-3-(2-methoxy-ethyl)-pyrrolidin-2-one; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-(2-methoxy-ethyl)-pyrrolidin-2-one; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-pyrrolidin-2-one; (1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-((R)-3-isopropyl-pyrrolidin-1-yl)-pyridin-3-yl]-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-[5-((2R,6S)-2,6-dimethyl-morpholin-4-yl)-pyridin-3-yl]-(4-isopropyl-phenyl)-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(6-oxa-3-aza-bicyclo[3.1.1]hept-3-yl)-pyridin-3-yl]-methanol; (R)-[5-((3R,4S)-3,4-Difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol; (R)-[5-((3S,4S)-3,4-Difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-[5-((2S,6S)-2,6-dimethyl-morpholin-4-yl)-pyridin-3-yl]-(4-isopropyl-phenyl)-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-[5-((2R,6R)-2,6-dimethyl-morpholin-4-yl)-pyridin-3-yl]-(4-isopropyl-phenyl)-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[3-(3-methyl-[1,2,4]oxadiazol-5-yl)-pyrrolidin-1-yl]-pyridin-3-yl}-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[3-(4-methyl-thiazol-2-yl)-pyrrolidin-1-yl]-pyridin-3-yl}-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(3-phenyl-pyrrolidin-1-yl)-pyridin-3-yl]-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-[5-(3,3-dimethyl-pyrrolidin-1-yl)-pyridin-3-yl]-(4-isopropyl-phenyl)-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[(1S,4S)-5-(2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl)-pyridin-3-yl]-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(2,2,6,6-tetrafluoro-morpholin-4-yl)-pyridin-3-yl]-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-((R)-2-methoxymethyl-morpholin-4-yl)-pyridin-3-yl]-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-((S)-2-methoxymethyl-morpholin-4-yl)-pyridin-3-yl]-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(3-trifluoromethyl-pyrrolidin-1-yl)-pyridin-3-yl]-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[(1R,4R)-5-(2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl)-pyridin-3-yl]-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[(1S,5R)-5-(8-oxa-3-aza-bicyclo[3.2.1]oct-3-yl)-pyridin-3-yl]-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-[(1S,4S)-5-(2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl)-pyridin-3-yl]-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-ethyl-phenyl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-ethyl-phenyl)-[5-(6-oxa-3-aza-bicyclo[3.1.1]hept-3-yl)-pyridin-3-yl]-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-ethyl-phenyl)-[(1S,4S)-5-(2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl)-pyridin-3-yl]-methanol; (R)-(5-Benzyloxy-pyridin-3-yl)-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol; (1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(2-pyridin-2-yl-ethoxy)-pyridin-3-yl]-methanol; (1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(2-methoxy-ethoxy)-pyridin-3-yl]-methanol; (1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(oxetan-3-ylmethoxy)-pyridin-3-yl]-methanol; 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yloxy}-propan-1-ol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(5-isopropoxy-pyridin-3-yl)-(4-isopropyl-phenyl)-methanol; (R)-(5-Cyclohexyloxy-pyridin-3-yl)-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yloxy}-2-methyl-propan-2-ol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(3-methoxy-cyclopentyloxy)-pyridin-3-yl]-methanol; (R)-[5-(3-Cyclopropyl-[1,2,4]oxadiazol-5-ylmethoxy)-pyridin-3-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-{5-[2-(3,5-dimethyl-[1,2,4]triazol-1-yl)-ethoxy]-pyridin-3-yl}-(4-isopropyl-phenyl)-methanol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yloxy}-2-methyl-butan-2-ol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-methoxy-pyridin-3-yl)-methanol; (R)-[5-(2-Benzyloxy-ethoxy)-pyridin-3-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(tetrahydro-pyran-4-yloxy)-pyridin-3-yl]-methanol; 2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yloxy}-ethanol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yloxy}-cyclohexanol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yloxy}-1-methyl-cyclohexanol; (1,3-Dimethyl-azetidin-3-yl)-(2-phenoxy-pyrimidin-5-yl)-(4-trifluoromethoxy-phenyl)-methanol; (6-Benzyloxy-pyridin-3-yl)-(1,3-dimethyl-azetidin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol; (1,3-Dimethyl-azetidin-3-yl)-(5-pyrazol-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol; (1,3-Dimethyl-azetidin-3-yl)-(6-fluoro-5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol; 5-[(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-trifluoromethoxy-phenyl)-methyl]-3-pyrrolidin-1-yl-pyridine-2-carbonitrile; (1,3-Dimethyl-azetidin-3-yl)-[6-(tetrahydro-pyran-4-yloxy)-pyridin-3-yl]-(4-trifluoromethoxy-phenyl)-methanol; (1,3-Dimethyl-azetidin-3-yl)-[6-(oxetan-3-ylmethoxy)-pyridin-3-yl]-(4-trifluoromethoxy-phenyl)-methanol; (1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(4-methyl-thiazol-2-yl)-pyridin-3-yl]-methanol; (1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(5-methyl-thiazol-2-yl)-pyridin-3-yl]-methanol; (1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(2-methoxy-pyrimidin-5-yl)-methanol; (S)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(2-pyrrolidin-1-yl-pyridin-4-yl)-methanol; (1,3-Dimethyl-azetidin-3-yl)-[2-((R)-2-hydroxymethyl-pyrrolidin-1-yl)-pyridin-4-yl]-(4-isopropyl-phenyl)-methanol; (1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4′-yl)-methanol; (1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(2-morpholin-4-yl-pyridin-4-yl)-methanol; (S)-(1,3-Dimethyl-azetidin-3-yl)-(2-ethyl-pyridin-4-yl)-(4-isopropyl-phenyl)-methanol; (S)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[2-(tetrahydro-pyran-4-ylmethoxy)-pyridin-4-yl]-methanol; (S)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[2-(2-methoxy-ethoxy)-pyridin-4-yl]-methanol; (S)-(2-Cyclopentyl-pyridin-4-yl)-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethyl-phenyl)-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-[5-((R)-3-hydroxymethyl-3-methyl-pyrrolidin-1-yl)-pyridin-3-yl]-(4-isopropyl-phenyl)-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-[5-((S)-3-fluoro-pyrrolidin-1-yl)-pyridin-3-yl]-(4-isopropyl-phenyl)-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[4-(tetrahydro-pyran-4-yl)-[1,2,3]triazol-1-yl]-pyridin-3-yl}-methanol; (1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-methyl-pyridin-3-yl)-methanol; (1,3-Dimethyl-azetidin-3-yl)-(5-isopropenyl-pyridin-3-yl)-(4-isopropyl-phenyl)-methanol; (5-Cyclopropyl-pyridin-3-yl)-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol; (5-Cyclopent-1-enyl-pyridin-3-yl)-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol; 3-{5-[(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-cyclopent-2-enol; (1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-isopropyl-pyridin-3-yl)-methanol; (5-Cyclopentyl-pyridin-3-yl)-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol; 3-{5-[(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-cyclopentanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-pyridin-3-yl-methanol; 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-cyclopent-2-enone; 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-methyl-cyclopent-2-enol; (3S)-3-(5-((R)-(1,3-dimethylazetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1-methylcyclopentan-1-ol; (3R)-3-(5-((R)-(1,3-dimethylazetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1-methylcyclopentan-1-ol; 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-ethyl-cyclopentanol; 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-isopropyl-cyclopentanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(4-methyl-oxazol-2-yl)-pyridin-3-yl]-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(5-ethyl-pyridin-3-yl)-(4-isopropyl-phenyl)-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-methyl-pyridin-3-yl)-methanol; (R)-[5-(4,5-Dihydro-furan-3-yl)-pyridin-3-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(tetrahydro-furan-3-yl)-pyridin-3-yl]-methanol; 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-but-3-en-1-ol; N-Cyclopentyl-5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-nicotinamide; {5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-pyrrolidin-1-yl-methanone; 5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-N-(tetrahydro-pyran-4-yl)-nicotinamide; (1,3-Dimethyl-azetidin-3-yl)-[4-(3-methoxy-propyl)-phenyl]-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol; (R)-(4-Cyclopropyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-p-tolyl-methanol; 5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-3′,4′,5′,6′-tetrahydro-2′H-[3,4′]bipyridinyl-1′-carboxylic acid tert-butyl ester; 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-pyrrolidine-1-carboxylic acid tert-butyl ester; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(tetrahydro-pyran-4-yl)-pyridin-3-yl]-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(3′,4′,5′,6′-tetrahydro-2′H-[2,1′;4′,3″ ]terpyridin-5″-yl)-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(1′-phenyl-1′,2′,3′,4′,5′,6′-hexahydro-[3,4′]bipyridinyl-5-yl)-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[1′-(toluene-4-sulfonyl)-1′,2′,3′,4′,5′,6′-hexahydro-[3,4′]bipyridinyl-5-yl]-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(tetrahydro-furan-2-yl)-pyridin-3-yl]-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(5-methyl-tetrahydro-furan-2-yl)-pyridin-3-yl]-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-[5-(5,5-dimethyl-tetrahydro-furan-2-yl)-pyridin-3-yl]-(4-isopropyl-phenyl)-methanol; 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2,2-difluoro-propan-1-ol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(5-methyl-oxazol-2-yl)-pyridin-3-yl]-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(tetrahydro-pyran-4-yl)-oxazol-2-yl]-pyridin-3-yl}-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-[5-(4-fluoro-phenoxymethyl)-pyridin-3-yl]-(4-isopropyl-phenyl)-methanol; Isopropyl-carbamic acid 5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylmethyl ester; (R)-[5-(2-Benzyloxy-ethyl)-pyridin-3-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-methyl-cyclohexanol; 2-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-cyclopropyl)-propan-2-ol; (S)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{2-[5-(tetrahydro-pyran-4-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-4-yl}-methanol; (1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(2-pyrrolidin-1-yl-pyrimidin-5-yl)-methanol; (1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(6-pyrrolidin-1-yl-pyrazin-2-yl)-methanol; (R)—N-(1-(3-(5-((1,3-dimethylazetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1,2,4-oxadiazol-5-yl)cyclopropyl)acetamide-2,2,2-d 3 ; (R)—N-(1-(3-(5-((1,3-dimethylazetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1,2,4-oxadiazol-5-yl)cyclopropyl)-N-methylacetamide-d 3 ; (R)—N-((3-(5-((1,3-dimethylazetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1,2,4-oxadiazol-5-yl)methyl)-N-methylacetamide-d 3 ; N-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-ylmethyl)-2-hydroxy-acetamide; (R)—N-((3-(5-((1,3-dimethylazetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1,2,4-oxadiazol-5-yl)methyl)acetamide-2,2,2-d 3 ; 1-(3-{5-[(R)-Hydroxy-(1-isopropyl-3-methyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-2-methyl-propan-2-ol; 1-(3-{5-[(R)-(1-Ethyl-3-methyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-2-methyl-propan-2-ol; 2-(3-{5-[(R)-Hydroxy-(1-isopropyl-3-methyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan-2-ol; 2-(3-{5-[(R)-(1-Ethyl-3-methyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan-2-ol; 4-(5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-3-yl)-piperidine-1-carboxylic acid benzyl ester; 1-[4-(5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-3-yl)-piperidin-1-yl]-ethanone; (R)-1-(3-(3-(5-((1,3-dimethylazetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1,2,4-oxadiazol-5-yl)azetidin-1-yl)ethan-1-one-2,2,2-d 3 ; (R)-1-(3-(3-(5-((1,3-dimethylazetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1,2,4-oxadiazol-5-yl)-3-methylazetidin-1-yl)ethan-1-one-2,2,2-d 3 ; (R)-1-(3-(3-(5-((1,3-dimethylazetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1,2,4-oxadiazol-5-yl)-3-fluoroazetidin-1-yl)ethan-1-one-2,2,2-d 3 ; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(1-methyl-1-morpholin-4-yl-ethyl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-methanol; 4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1-methyl-piperidin-2-one; 1-[(S)-3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-pyrrolidin-1-yl]-ethanone; 1-[(R)-3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-pyrrolidin-1-yl]-ethanone; N-[1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1-methyl-ethyl]-acetamide; 1-Benzyl-3-(3-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-pyrrolidin-2-one; 3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1,3-dimethyl-pyrrolidin-2-one; 4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1-isobutyl-pyrrolidin-2-one; 4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1-furan-2-ylmethyl-pyrrolidin-2-one; 4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1-phenyl-pyrrolidin-2-one; 1-Benzyl-4-(3-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-pyrrolidin-2-one; 5-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1-phenyl-pyrrolidin-2-one; 4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-pyrrolidin-2-one; (S)-5-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-pyrrolidin-2-one; (R)-5-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-pyrrolidin-2-one; (S)-6-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-2-one; 4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-2-one; (S)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-azetidin-2-one; (S)-3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-azetidin-2-one; (R)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1,4-dimethyl-pyrrolidin-2-one; (S)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1,4-dimethyl-pyrrolidin-2-one; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(5-piperidin-4-yl-[1,2,4]oxadiazol-3-yl)-pyridin-3-yl]-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(4-methyl-piperidin-4-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-{5-[5-(4-fluoro-piperidin-4-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-(4-isopropyl-phenyl)-methanol; 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-butan-1-one; 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-2,2-dimethyl-propan-1-one; 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-2-methoxy-ethanone; 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-3-methoxy-propan-1-one; Cyclopropyl-[4-(3-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-methanone; Cyclopentyl-[4-(3-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-methanone; [4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-(tetrahydro-pyran-4-yl)-methanone; [4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-phenyl-methanone; 4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidine-1-carboxylic acid methyl ester; 4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidine-1-carboxylic acid ethyl ester; 4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidine-1-carboxylic acid 2-methoxy-ethyl ester; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(1-methanesulfonyl-piperidin-4-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-{5-[1-(propane-2-sulfonyl)-piperidin-4-yl]-[1,2,4]oxadiazol-3-yl}-pyridin-3-yl)-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-{5-[1-(propane-1-sulfonyl)-piperidin-4-yl]-[1,2,4]oxadiazol-3-yl}-pyridin-3-yl)-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-{5-[1-(2-methoxy-ethanesulfonyl)-piperidin-4-yl]-[1,2,4]oxadiazol-3-yl}-pyridin-3-yl)-methanol; 2-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidine-1-sulfonyl]-ethanol; (R)-{5-[5-(1-Cyclopentanesulfonyl-piperidin-4-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-{5-[1-(tetrahydro-pyran-4-sulfonyl)-piperidin-4-yl]-[1,2,4]oxadiazol-3-yl}-pyridin-3-yl)-methanol; 4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidine-1-sulfonic acid methylamide; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(1-methylamino-cyclopropyl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-methanol; [1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-cyclopropyl]-methyl-carbamic acid ethyl ester; N-[1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-cyclopropyl]-N-methyl-methanesulfonamide; (R)-(1,3-Dimethyl-azetidin-3-yl)-[6-(2,2-dimethyl-cyclopentyloxy)-pyridazin-4-yl]-(4-isopropyl-phenyl)-methanol; (R)-[6-(3,3-Difluoro-cyclopentyloxy)-pyridazin-4-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol; 2-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yloxy}-phenyl)-ethanol; 2-(4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yloxy}-phenyl)-ethanol; (R)-[6-(Chroman-6-yloxy)-pyridazin-4-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol; 6-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yloxy}-3H-benzooxazol-2-one; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-3-(6-methyl-pyrimidin-4-yl)-pent-1-yn-3-ol; (S)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl-pyrimidin-4-yl)-but-3-yn-2-ol; (R)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl-pyrimidin-4-yl)-but-3-yn-2-ol; (S)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1,5-dimethyl-1H-pyrazol-3-yl)-but-3-yn-2-ol; (R)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1,5-dimethyl-1H-pyrazol-3-yl)-but-3-yn-2-ol; (R)-(1,3-Dimethyl-azetidin-3-yl)-{5-[1-(4-fluoro-phenyl)-cyclopropylethynyl]-pyridin-3-yl)-(4-isopropyl-phenyl)-methanol; (S)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1-methyl-1H-pyrazol-3-yl)-but-3-yn-2-ol; (R)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1-methyl-1H-pyrazol-3-yl)-but-3-yn-2-ol; 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-3-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-piperidine-1-carboxylic acid tert-butyl ester; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-3-(6-methyl-pyrimidin-4-yl)-pentan-3-ol; 2-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-ethyl)-benzoic acid methyl ester; (R)-(1,3-Dimethyl-azetidin-3-yl)-{5-[2-(2-hydroxymethyl-phenyl)-ethyl]-pyridin-3-yl}-(4-isopropyl-phenyl)-methanol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methoxy-pyrimidin-4-yl)-butan-2-ol; 3-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-ethyl)-3-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[2-(1H-pyrrolo[2,3-b]pyridin-2-yl)-ethyl]-pyridin-3-yl}-methanol; 4-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-ethyl)-piperidine-1-carboxylic acid tert-butyl ester; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-pyridin-2-yl-butan-2-ol; 1-Cyclopropyl-3-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-pyridin-2-yl-propan-1-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(5-methyl-pyridin-3-yl)-butan-2-ol; 8-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-ethyl)-5,6,7,8-tetrahydro-quinolin-8-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-2-(6-methoxy-pyridin-2-yl)-butan-2-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-2-(6-methyl-pyridin-2-yl)-butan-2-ol; (1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(6-pyrrolidin-1-yl-pyridin-2-yl)-methanol; 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-4-fluoro-piperidin-1-yl]-ethanone; 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-4-methyl-piperidin-1-yl]-ethanone; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yloxy}-cyclohexanone; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-cyclohexanol; (R)-(5-Cyclopentyloxymethyl-pyridin-3-yl)-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol; 1-(4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylmethoxy}-piperidin-1-yl)-ethanone; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[6-(tetrahydro-pyran-4-yl)-pyridazin-4-yl]-methanol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-2-phenyl-butan-2-ol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{6-[(S)-(tetrahydro-furan-3-yl)oxy]-pyridazin-4-yl}-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{6-[(R)-(tetrahydro-furan-3-yl)oxy]-pyridazin-4-yl}-methanol; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-4-methyl-pyrrolidin-2-one; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-3-isopropyl-pyrrolidin-2-one; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-3,3-dimethyl-pyrrolidin-2-one; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-4,4-dimethyl-pyrrolidin-2-one; 5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-5-aza-spiro[2.4]heptan-6-one; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-4-trifluoromethyl-pyrrolidin-2-one; 4-Cyclopropyl-1-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-pyrrolidin-2-one; 2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-8-oxa-2-aza-spiro[4.5]decan-3-one; 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-1-oxa-3-aza-spiro[4.5]decan-2-one; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-4-pyridin-2-yl-pyrrolidin-2-one; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-3-(2-methoxy-ethyl)-pyrrolidin-2-one; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-4-phenyl-pyrrolidin-2-one; 2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-2,3-dihydro-isoindol-1-one; 2-(3-{5-[(S)-(3-Fluoro-1-methyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan-2-ol; 2-(3-{5-[(S)-(1-Cyclopropyl-3-fluoro-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan-2-ol; 1-[4-(3-{5-[(S)-(3-Fluoro-1-methyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-ethanone; 1-[4-(3-{5-[(S)-(1-Cyclopropyl-3-fluoro-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-ethanone; 2-(3-{5-[(R)-(1-Cyclopropyl-3-methyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan-2-ol; 1-[4-(3-{5-[(R)-(1-Cyclopropyl-3-methyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-ethanone; (R)-(1-Cyclopropyl-3-methyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(tetrahydro-pyran-4-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-methanol; trans-4-(3-{5-[(R)-(1-Cyclopropyl-3-methyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-cyclohexanol; (R)-(1-Cyclopropyl-3-methyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(5-oxetan-3-yl-[1,2,4]oxadiazol-3-yl)-pyridin-3-yl]-methanol; 1-[(R)-3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-ylmethyl)-pyrrolidin-1-yl]-ethanone; 1-[3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-ethanone; 1-[3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-3-hydroxy-piperidin-1-yl]-ethanone; 1-[3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-3-methyl-piperidin-1-yl]-ethanone; 1-[3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-ylmethyl)-piperidin-1-yl]-ethanone; 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-ylmethyl)-4-hydroxy-piperidin-1-yl]-ethanone; N-[1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-ylmethyl)-cyclopropyl]-acetamide; Tetrahydro-pyran-4-carboxylic acid [1-(3-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-ylmethyl)-cyclopropyl]-amide; N-[1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-ylmethyl)-cyclopropyl]-2-methoxy-acetamide; N-[1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-ylmethyl)-cyclopropyl]-N-methyl-acetamide; N-[2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1,1-dimethyl-ethyl]-propionamide; N-[2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1,1-dimethyl-ethyl]-2-methoxy-acetamide; Tetrahydro-pyran-4-carboxylic acid [2-(3-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1,1-dimethyl-ethyl]-amide; N-[2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1,1-dimethyl-ethyl]-isobutyramide; Cyclopropanecarboxylic acid [2-(3-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1,1-dimethyl-ethyl]-amide; 1-[cis-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-2-methyl-piperidin-1-yl]-ethanone; 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-4-hydroxy-piperidin-1-yl]-2-methyl-propan-1-one; 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-4-hydroxy-piperidin-1-yl]-propan-1-one; 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-4-methoxy-piperidin-1-yl]-ethanone; 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-3,3,3-trifluoro-propan-1-one; 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-2-oxetan-3-yl-ethanone; 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-4-ethyl-piperidin-1-yl]-ethanone; [4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-oxetan-3-yl-methanone; 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-4-isopropyl-piperidin-1-yl]-2-methoxy-ethanone; 1-[cis-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-3-methyl-piperidin-1-yl]-ethanone; 5-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1-methyl-piperidin-2-one; 5-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-5-methyl-piperidin-2-one; 5-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-2-one; 4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-4-methyl-pyrrolidin-2-one; 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-ylmethyl)-3,3-dimethyl-pyrrolidine-2,5-dione; 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-ylmethyl)-imidazolidine-2,4-dione; 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-ylmethyl)-pyrrolidin-2-one; 3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-ylmethyl)-imidazolidine-2,4-dione; 3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-ylmethyl)-1-methyl-imidazolidine-2,4-dione; 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-ylmethyl)-3-methyl-imidazolidine-2,4-dione; 3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-ylmethyl)-oxazolidin-2-one; 1-Cyclopropyl-3-(3-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-ylmethyl)-imidazolidin-2-one; 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-ylmethyl)-pyrrolidine-2,5-dione; 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-ylmethyl)-3-methyl-imidazolidin-2-one; 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-ylmethyl)-imidazolidin-2-one; 2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propane-1,2-diol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(5-pyridin-3-yl-[1,2,4]oxadiazol-3-yl)-pyridin-3-yl]-methanol; 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-ylmethyl)-piperidin-1-yl]-ethanone; (3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-acetonitrile; 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-4-hydroxy-piperidin-1-yl]-ethanone; 3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propionitrile; 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-3-methoxy-piperidin-1-yl]-ethanone; 1-[(R)-3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-ethanone; 4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-tetrahydro-pyran-4-ol; (R)-(1,3-Dimethyl-azetidin-3-yl)-{5-[5-(3-hydroxymethyl-bicyclo[1.1.1]pent-1-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-(4-isopropyl-phenyl)-methanol; 4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1-methyl-piperidine-2,6-dione; 2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-2,2-difluoro-ethanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(3-methoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-[5-(5-isopropyl-[1,2,4]oxadiazol-3-yl)-pyridin-3-yl]-(4-isopropyl-phenyl)-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(6-methyl-pyrimidin-4-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-methanol; (R)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1-methyl-pyrrolidin-2-one; (S)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1-methyl-pyrrolidin-2-one; (S)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1-ethyl-pyrrolidin-2-one; (R)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1-ethyl-pyrrolidin-2-one; (S)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1-isopropyl-pyrrolidin-2-one; (R)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1-isopropyl-pyrrolidin-2-one; 1-[(S)-3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-ylmethyl)-pyrrolidin-1-yl]-ethanone; (S)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-2-one; (R)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-2-one; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(5-methyl-[1,2,4]oxadiazol-3-yl)-pyridin-3-yl]-methanol; (R)-{5-[5-(1,1-Difluoro-ethyl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol; 4-(5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-3-yl)-tetrahydro-pyran-4-ol; (R)-[5-(3-tert-Butoxymethyl-[1,2,4]oxadiazol-5-yl)-pyridin-3-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-[5-(3-hydroxymethyl-[1,2,4]oxadiazol-5-yl)-pyridin-3-yl]-(4-isopropyl-phenyl)-methanol; 1-[4-(5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-3-yl)-piperazin-1-yl]-ethanone; 1-[3-(5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-3-ylmethyl)-azetidin-1-yl]-ethanone; 4-(5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-3-ylmethyl)-tetrahydro-pyran-4-ol; [4-(5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-3-yl)-piperidin-1-yl]-[1,4]dioxan-2-yl-methanone; 1-[4-(5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-3-yl)-piperidin-1-yl]-2-methoxy-ethanone; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[3-(1-methanesulfonyl-piperidin-4-yl)-[1,2,4]oxadiazol-5-yl]-pyridin-3-yl}-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-{3-[1-(2-methoxy-ethanesulfonyl)-piperidin-4-yl]-[1,2,4]oxadiazol-5-yl}-pyridin-3-yl)-methanol; 1-[4-(5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-3-yl)-piperidin-1-yl]-2-hydroxy-ethanone; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-[1,2,4]oxadiazol-3-yl-pyridin-3-yl)-methanol; 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-ethanone; 2-(3-{5-[(R)-(4-Bromo-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan-2-ol; 2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-naphthalen-2-yl-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan-2-ol; 2-[3-(5-{(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-methyl}-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-propan-2-ol; 2-[3-(5-{(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-[4-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-phenyl]-methyl}-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-propan-2-ol; 2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropoxy-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan-2-ol; 2-[3-(5-{(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-[4-(1,2,2,2-tetrafluoro-1-trifluoromethyl-ethyl)-phenyl]-methyl}-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-propan-2-ol; (R)-2-(3-(5-((1,3-dimethylazetidin-3-yl)(hydroxy)(4-(pentafluoro-λ 6 -sulfanyl)phenyl)methyl)pyridin-3-yl)-1,2,4-oxadiazol-5-yl)propan-2-ol; 2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-(3-fluoro-4-isopropyl-phenyl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan-2-ol; 2-(3-{5-[(R)-(4-tert-Butyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan-2-ol; 2-(3-{5-[(R)-Benzo[b]thiophen-5-yl-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan-2-ol; 2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-pentafluoroethyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan-2-ol; 2-[3-(5-{(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-[4-(1-methyl-cyclopropyl)-phenyl]-methyl}-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-propan-2-ol; 2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-3-methyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan-2-ol; 2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-trifluoromethoxy-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan-2-ol; 1-[4-(3-{5-[(R)-(4-Bromo-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-ethanone; 2-[3-(5-{(R)-(1,3-Dimethyl-azetidin-3-yl)-[4-(1-fluoro-1-methyl-ethyl)-phenyl]-hydroxy-methyl}-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-propan-2-ol; 2-(3-{5-[(R)-[4-(1,1-Difluoro-ethyl)-phenyl]-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan-2-ol; 2-(3-{5-[(R)-(4-Bicyclo[1.1.1]pent-1-yl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan-2-ol; (R)-(1,3-Dimethyl-azetidin-3-yl)-{5-[5-(tetrahydro-pyran-4-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-[4-(2,2,2-trifluoro-ethyl)-phenyl]-methanol; 2-[3-(5-{(R)-(1,3-Dimethyl-azetidin-3-yl)-[4-(1,1-dimethyl-propyl)-phenyl]-hydroxy-methyl}-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-propan-2-ol; 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-(3-fluoro-4-isopropyl-phenyl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-ethanone; 1-{4-[3-(5-{(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-methyl}-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-ethanone; 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-trifluoromethoxy-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-ethanone; 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropoxy-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-ethanone; 2-(3-{5-[(R)-(3-Chloro-4-isopropyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan-2-ol; 2-(3-{5-[(R)-(4-Cyclobutyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan-2-ol; 1-[4-(3-{5-[(R)-(4-Cyclobutyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-ethanone; 1-[4-(3-{5-[(R)-(3,5-Difluoro-4-isopropyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-ethanone; 2-(3-{5-[(R)-(3,5-Difluoro-4-isopropyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan-2-ol; 1-[4-(3-{5-[(R)-(4-Cyclobutoxy-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-ethanone; 2-[3-(5-{(1,3-Dimethyl-azetidin-3-yl)-[4-(1-ethyl-propyl)-phenyl]-hydroxy-methyl}-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-propan-2-ol; 1-{4-[3-(5-{(1,3-Dimethyl-azetidin-3-yl)-[4-(2,2-dimethyl-propyl)-phenyl]-hydroxy-methyl}-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-ethanone; 2-[3-(5-{(1,3-Dimethyl-azetidin-3-yl)-[4-(2,2-dimethyl-propyl)-phenyl]-hydroxy-methyl}-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-propan-2-ol; 1-{4-[3-(5-{(1,3-Dimethyl-azetidin-3-yl)-[4-(2,2-dimethyl-propyl)-phenyl]-hydroxy-methyl}-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-ethanone; 1-{4-[3-(5-{(1,3-Dimethyl-azetidin-3-yl)-hydroxy-[4-(1-methyl-cyclopropyl)-phenyl]-methyl}-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-ethanone; 2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-propyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan-2-ol; 2-(3-{5-[(R)-(4-Cyclopropyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan-2-ol; 2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-ethyl-phenyl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan-2-ol; 2-(3-{5-[(R)-(4-Butyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan-2-ol; 2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-trifluoromethyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan-2-ol; 2-[3-(5-{(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-[4-(2,2,2-trifluoro-ethyl)-phenyl]-methyl}-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-propan-2-ol; 2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isobutyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan-2-ol; 2-(3-{5-[(R)-(4-Cyclobutoxy-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan-2-ol; 2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropenyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan-2-ol; 1-{4-[3-(5-{(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-[4-(2,2,2-trifluoro-ethyl)-phenyl]-methyl}-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-ethanone; 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-propyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-ethanone; 1-[4-(3-{5-[(R)-Hydroxy-(1-isopropyl-3-methyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-ethanone; 1-[4-(3-{5-[(R)-[1-(2,2-Difluoro-ethyl)-3-methyl-azetidin-3-yl]-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-ethanone; 1-[4-(3-{5-[(R)-Hydroxy-[1-(2-hydroxy-ethyl)-3-methyl-azetidin-3-yl]-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-ethanone; 1-[4-(3-{5-[(R)-(1-Cyclopropylmethyl-3-methyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-ethanone; 1-{4-[3-(5-{(R)-Hydroxy-(4-isopropyl-phenyl)-[1-(2-methoxy-ethyl)-3-methyl-azetidin-3-yl]-methyl}-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-ethanone; 1-{4-[3-(5-{(R)-Hydroxy-(4-isopropyl-phenyl)-[3-methyl-1-(3,3,3-trifluoro-propyl)-azetidin-3-yl]-methyl}-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-ethanone; 1-[4-(3-{5-[(R)-Hydroxy-(4-isopropyl-phenyl)-(3-methyl-1-propyl-azetidin-3-yl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-ethanone; 1-[4-(3-{5-[(R)-(1-Ethyl-3-methyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-ethanone; 1-(4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-piperidin-1-yl)-ethanone; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1,1,1-trifluoro-2-methyl-but-3-yn-2-ol; Cyclopropanecarboxylic acid (3-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1,1-dimethyl-prop-2-ynyl)-amide; N-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1,1-dimethyl-prop-2-ynyl)-isobutyramide; N-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1,1-dimethyl-prop-2-ynyl)-2-methoxy-acetamide; 3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1,1-dimethyl-prop-2-ynyl)-oxazolidin-2-one; 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1,1-dimethyl-prop-2-ynyl)-pyrrolidin-2-one; 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1,1-dimethyl-prop-2-ynyl)-3-methyl-imidazolidin-2-one; 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1,1-dimethyl-prop-2-ynyl)-imidazolidin-2-one; 3-(1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-cyclopropyl)-oxazolidin-2-one; 1-((R)-2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-2-methyl-pyrrolidin-1-yl)-ethanone; 1-(4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-4-hydroxy-piperidin-1-yl)-ethanone; 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-hydroxy-1-methyl-prop-2-ynyl)-piperidin-1-yl]-ethanone; 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-hydroxy-prop-2-ynyl)-piperidin-1-yl]-ethanone; 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-prop-2-ynyl)-piperidin-1-yl]-ethanone; 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-hydroxy-prop-2-ynyl)-4-methyl-piperidin-1-yl]-ethanone; 1-(4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-4-methyl-piperidin-1-yl)-ethanone; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(1-methanesulfonyl-piperidin-4-ylethynyl)-pyridin-3-yl]-methanol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-4-methyl-piperidine-1-sulfonic acid methylamide; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(3-methanesulfonyl-3-methyl-but-1-ynyl)-pyridin-3-yl]-methanol; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-cyclopropanesulfonic acid dimethylamide; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-cyclopropanesulfonic acid amide; (R)-[5-(3-Cyclopropanesulfonyl-3-methyl-but-1-ynyl)-pyridin-3-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol; (R)-3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-3-hydroxy-1-methyl-pyrrolidin-2-one; (S)-3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-3-hydroxy-1-methyl-pyrrolidin-2-one; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-ol; 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-3-hydroxy-1-methyl-1,3-dihydro-indol-2-one; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1H-indazol-3-yl)-but-3-yn-2-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1-methyl-1H-indazol-3-yl)-but-3-yn-2-ol; 2-(1-Cyclopropyl-1H-pyrazol-3-yl)-4-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-but-3-yn-2-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methyl-pyrimidin-4-yl)-but-3-yn-2-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(5-methyl-pyrazin-2-yl)-but-3-yn-2-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methyl-thiazol-5-yl)-but-3-yn-2-ol; 2-(6-Cyclopropyl-pyrimidin-4-yl)-4-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-but-3-yn-2-ol; N-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1,1-dimethyl-prop-2-ynyl)-acetamide; (S)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methoxy-pyrimidin-4-yl)-but-3-yn-2-ol; (R)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methoxy-pyrimidin-4-yl)-but-3-yn-2-ol; (R)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methoxy-pyrimidin-4-yl)-but-3-yn-2-ol; (S)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methoxy-pyrimidin-4-yl)-but-3-yn-2-ol; (S)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2,6-dimethyl-pyrimidin-4-yl)-but-3-yn-2-ol; (R)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2,6-dimethyl-pyrimidin-4-yl)-but-3-yn-2-ol; (S)-2-(2,6-Dimethoxy-pyrimidin-4-yl)-4-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-but-3-yn-2-ol; (R)-2-(2,6-Dimethoxy-pyrimidin-4-yl)-4-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-but-3-yn-2-ol; (S)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methoxy-6-methyl-pyrimidin-4-yl)-but-3-yn-2-ol; (R)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methoxy-6-methyl-pyrimidin-4-yl)-but-3-yn-2-ol; (R)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methoxy-2-methyl-pyrimidin-4-yl)-but-3-yn-2-ol; (S)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methoxy-2-methyl-pyrimidin-4-yl)-but-3-yn-2-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-trifluoromethyl-pyrimidin-4-yl)-but-3-yn-2-ol; 2-(6-Difluoromethyl-pyrimidin-4-yl)-4-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-but-3-yn-2-ol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(1-pyridin-2-yl-cyclopropylethynyl)-pyridin-3-yl]-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[1-(6-methyl-pyrimidin-4-yl)-cyclopropylethynyl]-pyridin-3-yl}-methanol; 1-[4-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-ethyl)-piperidin-1-yl]-ethanone; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1,1,1-trifluoro-2-methyl-butan-2-ol; 3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1,1-dimethyl-propyl)-oxazolidin-2-one; 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1,1-dimethyl-propyl)-pyrrolidin-2-one; 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1,1-dimethyl-propyl)-3-methyl-imidazolidin-2-one; 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1,1-dimethyl-propyl)-imidazolidin-2-one; 1-[(S)-2-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-ethyl)-2-methyl-pyrrolidin-1-yl]-ethanone; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1H-indazol-3-yl)-butan-2-ol; 2-(1-Cyclopropyl-1H-pyrazol-3-yl)-4-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-butan-2-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methyl-pyrimidin-4-yl)-butan-2-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(5-methyl-pyrazin-2-yl)-butan-2-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methyl-thiazol-5-yl)-butan-2-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(3-methyl-isoxazol-5-yl)-but-3-yn-2-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1-methyl-1H-imidazol-2-yl)-but-3-yn-2-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(5-methyl-thiophen-2-yl)-but-3-yn-2-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1-methyl-1H-pyrrol-2-yl)-but-3-yn-2-ol; (R)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-trifluoromethyl-pyrimidin-4-yl)-but-3-yn-2-ol; (S)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-trifluoromethyl-pyrimidin-4-yl)-but-3-yn-2-ol; 4-(5-{(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-methyl}-pyridin-3-yl)-2-(6-methyl-pyridin-2-yl)-but-3-yn-2-ol; 4-(5-{(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-[4-(1-methyl-cyclopropyl)-phenyl]-methyl}-pyridin-3-yl)-2-(6-methyl-pyridin-2-yl)-but-3-yn-2-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-trifluoromethyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl-pyridin-2-yl)-but-3-yn-2-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-ethyl-phenyl)-hydroxy-methyl]-pyridin-3-yl}-2-(6-methyl-pyridin-2-yl)-but-3-yn-2-ol; 4-{5-[(R)-(4-tert-Butyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-2-(6-methyl-pyridin-2-yl)-but-3-yn-2-ol; 4-{5-[(R)-(3-Ethyl-1-methyl-azetidin-3-yl)-hydroxy-(4-trifluoromethoxy-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl-pyridin-2-yl)-but-3-yn-2-ol; 4-(5-{(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-[4-(2,2,2-trifluoro-ethyl)-phenyl]-methyl}-pyridin-3-yl)-2-(6-methyl-pyridin-2-yl)-but-3-yn-2-ol; 4-{5-[(S)-(3-Fluoro-1-methyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl-pyridin-2-yl)-but-3-yn-2-ol; 1-(4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-ylethynyl}-piperidin-1-yl)-ethanone; N-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-1,1-dimethyl-prop-2-ynyl)-acetamide; 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-1,1-dimethyl-prop-2-ynyl)-pyrrolidin-2-one; 4-{5-[(R)-Hydroxy-(1-isopropyl-3-methyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl-pyridin-2-yl)-but-3-yn-2-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl-pyridin-2-yl)-but-3-yn-2-ol; 4-{5-[(R)-Hydroxy-[1-(2-hydroxy-ethyl)-3-methyl-azetidin-3-yl]-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl-pyridin-2-yl)-but-3-yn-2-ol; 4-{5-[(R)-[1-(2,2-Difluoro-ethyl)-3-methyl-azetidin-3-yl]-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl-pyridin-2-yl)-but-3-yn-2-ol; 1-(4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yloxymethyl}-piperidin-1-yl)-ethanone; 4-{5-[(R)-(1-Cyclopropyl-3-methyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl-pyridin-2-yl)-but-3-yn-2-ol; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-(2-isopropyl-pyrimidin-4-yl)-pyrrolidin-2-one; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-(2-methyl-thiazol-5-yl)-pyrrolidin-2-one; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-(6-methyl-pyridin-3-yl)-pyrrolidin-2-one; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-(6-isopropyl-pyridin-2-yl)-pyrrolidin-2-one; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-(6-trifluoromethyl-pyridin-3-yl)-pyrrolidin-2-one; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-(1-methyl-1H-pyrazol-4-yl)-pyrrolidin-2-one; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-(1,3-dimethyl-1H-pyrazol-4-yl)-pyrrolidin-2-one; 4-(1-Difluoromethyl-1H-pyrazol-4-yl)-1-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-pyrrolidin-2-one; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-(2-methyl-2H-[1,2,3]triazol-4-yl)-pyrrolidin-2-one; 4-(1-Acetyl-piperidin-4-yl)-1-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-pyrrolidin-2-one; 5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-hexahydro-furo[2,3-c]pyrrol-4-one; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-4-(6-isopropyl-pyridin-2-yl)-pyrrolidin-2-one; 1-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-ethanone; 1-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-7,8-dihydro-5H-[1,6]naphthyridin-6-yl)-ethanone; 1-[4-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-pyrimidin-5-yl)-piperidin-1-yl]-ethanone; or 1-[4-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-pyrimidin-4-yl)-piperidin-1-yl]-ethanone; or a pharmaceutically acceptable salt thereof.
11. 11 . A compound according to claim 1 which is: 2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan-2-ol; 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-ethanone; or (S)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl-pyrimidin-4-yl)-but-3-yn-2-ol; or a pharmaceutically acceptable salt thereof.
12. 12 . A compound which is: 2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan-2-ol; or a pharmaceutically acceptable salt thereof.
13. 13 . A pharmaceutical composition comprising a compound according to claim 1 , or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable carrier.
14. 14 . A method for the prevention or treatment of an inflammatory/autoimmune disease/disorder, or cancer; said method comprising administering to a subject a pharmaceutically active amount of a compound according to claim 1 , or a pharmaceutically acceptable salt thereof, either alone or in combination with another pharmacologically active compounds and/or therapy.
15. 15 . A pharmaceutical composition comprising a compound according to claim 10 , or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable carrier.
16. 16 . A method for the prevention or treatment of an inflammatory/autoimmune disease/disorder, or cancer; said method comprising administering to a subject a pharmaceutically active amount of a compound according to claim 10 , or a pharmaceutically acceptable salt thereof, either alone or in combination with another pharmacologically active compound and/or therapy.
17. 17 . A pharmaceutical composition comprising a compound according to claim 11 , or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable carrier.
18. 18 . A method for the prevention or treatment of an inflammatory/autoimmune disease/disorder, or cancer; said method comprising administering to a subject a pharmaceutically active amount of a compound according to claim 11 , or a pharmaceutically acceptable salt thereof, either alone or in combination with another pharmacologically active compound and/or therapy.
19. 19 . A pharmaceutical composition comprising the compound according to claim 12 , or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable carrier.
20. 20 . A method for the prevention or treatment of an inflammatory/autoimmune disease/disorder, or cancer; said method comprising administering to a subject a pharmaceutically active amount of the compound according to claim 12 , or a pharmaceutically acceptable salt thereof, either alone or in combination with another pharmacologically active compound and/or therapy.

Description

CROSS REFERENCE TO RELATED APPLICATIONS This application is the National Stage Entry under 35 U.S.C. § 371 of International Application No. PCT/EP2021/061401 filed Apr. 30, 2021, which claims priority to International Application No. PCT/EP2020/062103 filed Apr. 30, 2020, the contents of each of which are hereby incorporated by reference in their entireties. The present invention relates to novel compounds of Formula (I), or pharmaceutically acceptable salts thereof, and their use as CCR6 receptor modulators in the treatment or prevention of various diseases, conditions or disorders ameliorated by modulating said receptor. Furthermore, the present invention concerns related aspects such as pharmaceutical compositions containing one or more compounds of Formula (I) and processes for the preparation of said compounds. Chemokine receptors comprise a family G-protein coupled receptors (GPCRs) that recognize and bind to peptide chemokine ligands. The predominant functions of chemokine receptors and their ligands are to induce leukocyte trafficking to-and-from lymphoid organs and tissues in the steady state, as well as in the context of an infection or inflammation. Additionally, chemokine signaling events can induce the activation of integrin molecules on the surface of immune cells, allowing firm adhesion to activated endothelium, facilitating migration from blood into inflamed tissue (Montresor A, Frontiers in Imm., 2012; Meissner A, Blood, 2003). Chemokine receptor 6 (CCR6, aliases BN-1, C-C CKR-6, CD196, CKRL3, CMKBR6, DCR2, DRY6, GPR29, GPRCY4, STRL22) is a GPCR mainly expressed on effector CD4+ T helper cells, but is also present on B cells, CD8+ cytotoxic T cells, regulatory T cells (Treg), immature dendritic cells (DC) and type 3 innate lymphoid cells (ILC3) (Cua D J, Nat Rev Immunol. 2010 July; 10(7):479-89. doi: 10.1038/nri2800). CCR6 binds to the chemokine CCL20 (chemokine (C—C motif) ligand 20) (Greaves D R, J Exp Med. 1997 Sep. 15; 186(6):837-44. doi: 10.1084/jem.186.6.837). CCL20 is also called macrophage inflammatory protein 3a (MIP-3a), liver and activation-regulated chemokine (LARC), or Exodus-1 (Schutyser E, Cytokine Growth Factor Rev. 2003 October; 1-((5):409-26. doi: 10.1016/s1359-6101(03)00049-2). CCR6/CCL20 interactions dictate the humoral response in the intestinal mucosa and are required for lymphocyte homeostasis in the mucosa of the small intestine (Cook D N, Immunity. 2000 May; 12(5):495-503. doi: 10.1016/s1074-7613(00)80201-0). Under steady state conditions, CCR6 and CCL20 regulate production of IgA in the intestine, where CCL20 expressed in Peyer's patches guides CCR6+IgA+ B cells to the mucosa and secretory IgA can be released into the gut lumen (Lin Y L, Front Immunol. 2017; 8:805. doi: 10.3389/fimmu.2017.00805; Reboldi A, Science. 2016 May 13; 352(6287):aaf4822. doi: 10.1126/science.aaf4822). Under inflammatory conditions, expression of CCL20 is highly upregulated by proinflammatory cytokines including IL-17A, TNFa and IL-1b in both endothelial and epithelial cells (Harper E G, J Invest Dermatol. 2009 September; 129(9):2175-83. doi: 10.1038/jid.2009.65; PLoS One. 2015; 10(11):e0141710. doi: 10.1371/journal.pone.0141710) and tissue fibroblasts (Hattori T, Mediators Inflamm. 2015; 2015:436067. doi: 10.1155/2015/436067). Interleukin (IL)-17A expression is restricted to cells expressing the transcription factor RORgt (Cell. 2006 Sep. 22; 126(6):1121-33. doi: 10.1016/j.cell.2006.07.035). IL-17A expression has been shown to segregate with CCR6 expression on human T cells (Singh S P, J Immunol. 2008 Jan. 1; 180(1):214-21. doi: 10.4049/jimmunol.180.1.214; Nat Immunol. 2007 June; 8(6):639-46. doi: 10.1038/ni1467). CCR6 was also described as a target gene of RORgt (PLoS One. 2017; 12(8):e0181868. doi: 10.1371/journal.pone.0181868; Skepner J, J Immunol. 2014 Mar. 15; 192(6):2564-75. doi: 10.4049/jimmunol.1302190), thus clarifying the co-expression of IL-17A and CCR6 in RORgt+ cell types. Certain disclosures in the prior art may be regarded as relating to modulation of CCR6. For instance, Tawaraishia et al. (Bioorganic & Medicinal Chemistry Letters, Volume 28, Issue 18, 2018, Pages 3067-3072, ISSN 0960-894X, https://doi.org/10.1016/j.bmc1.2018.07.042) disclose a series of benzenesulfonyl-aminocyclohexane derivatives as selective CCR6 inhibitors. CN103588697 teaches sulfonamide derivatives as CCR6 antagonists and their use in treating CCR6-mediated diseases such as autoimmune diseases, inflammation, psoriasis, multiple sclerosis or cancer. WO2014/075580 describes the use of aurintricarboxylic acid for targeting chemokine receptors. WO2015/084842 teaches certain sulfonamides which may be used in treating CCR6 related diseases. WO2017/087607, WO2010/131145, WO2013/061004, WO2013/061005, WO2019/036374 and WO2020/058869 provide certain cyclobutenediones for use in the treatment of chemokine/CCR6 related diseases. WO2019/136370 teaches a method of treating a certain type of psoriasis. WO2019/147862