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US-12617859-B2 - Therapeutic anti-CD40 ligand antibodies

US12617859B2US 12617859 B2US12617859 B2US 12617859B2US-12617859-B2

Abstract

Anti-CD40L antibodies and antigen binding fragments thereof, compositions comprising the antibodies or antigen binding fragments, Anti-CD40L antibodies with reduced effector function, and method of using same for treatment of CD40L-related diseases or disorders.

Inventors

  • Alexey Lugovskoy

Assignees

  • ALS THERAPY DEVELOPMENT INSTITUTE

Dates

Publication Date
20260505
Application Date
20220711

Claims (20)

  1. 1 . An isolated antibody or antigen-binding fragment thereof, that specifically binds to CD40L, comprising: (a) a heavy chain variable region (VH) comprising; i) a CDRH1 domain comprising the sequence set forth in SEQ ID NO:9; ii) a CDRH2 domain comprising the sequence set forth in SEQ ID NO: 10, 11, 12, 13, or 14; iii) a CDRH3 domain comprising the sequence set forth in SEQ ID NO: 15; and (b) a light chain variable region (VL) comprising: i) a CDRL1 domain comprising the sequence set forth in SEQ ID NO: 16 or 17; ii) a CDRL2 domain comprising the sequence set forth in SEQ ID NO: 18 or 19; iii) a CDRL3 domain comprising the sequence set forth in SEQ ID NO: 20.
  2. 2 . The isolated antibody or antigen-binding fragment thereof of claim 1 , comprising: (a) a heavy chain variable region (VH) comprising; i) a CDRH1 domain comprising the sequence set forth in SEQ ID NO: 9; ii) a CDRH2 domain comprising the sequence set forth in SEQ ID NO: 10; iii) a CDRH3 domain comprising the sequence set forth in SEQ ID NO: 15; and (b) a light chain variable region (VL) comprising: i) a CDRL1 domain comprising the sequence set forth in SEQ ID NO: 16; ii) a CDRL2 domain comprising the sequence set forth in SEQ ID NO: 18; iii) a CDRL3 domain comprising the sequence set forth in SEQ ID NO: 20; or (c) a heavy chain variable region (VH) comprising; i) a CDRH1 domain comprising the sequence set forth in SEQ ID NO: 9; ii) a CDRH2 domain comprising the sequence set forth in SEQ ID NO: 10; iii) a CDRH3 domain comprising the sequence set forth in SEQ ID NO: 15; and (d) a light chain variable region (VL) comprising: i) a CDRL1 domain comprising the sequence set forth in SEQ ID NO: 17; ii) a CDRL2 domain comprising the sequence set forth in SEQ ID NO: 18; iii) a CDRL3 domain comprising the sequence set forth in SEQ ID NO: 20; or (e) a heavy chain variable region (VH) comprising; i) a CDRH1 domain comprising the sequence set forth in SEQ ID NO: 9; ii) a CDRH2 domain comprising the sequence set forth in SEQ ID NO: 10; iii) a CDRH3 domain comprising the sequence set forth in SEQ ID NO: 15; and (f) a light chain variable region (VL) comprising: i) a CDRL1 domain comprising the sequence set forth in SEQ ID NO: 16; ii) a CDRL2 domain comprising the sequence set forth in SEQ ID NO: 19; iii) a CDRL3 domain comprising the sequence set forth in SEQ ID NO: 20; or (g) a heavy chain variable region (VH) comprising; i) a CDRH1 domain comprising the sequence set forth in SEQ ID NO: 9; ii) a CDRH2 domain comprising the sequence set forth in SEQ ID NO: 10; iii) a CDRH3 domain comprising the sequence set forth in SEQ ID NO: 15; and (h) a light chain variable region (VL) comprising: i) a CDRL1 domain comprising the sequence set forth in SEQ ID NO: 17; ii) a CDRL2 domain comprising the sequence set forth in SEQ ID NO: 19; iii) a CDRL3 domain comprising the sequence set forth in SEQ ID NO: 20; or (i) a heavy chain variable region (VH) comprising; i) a CDRH1 domain comprising the sequence set forth in SEQ ID NO: 9; ii) a CDRH2 domain comprising the sequence set forth in SEQ ID NO: 11; iii) a CDRH3 domain comprising the sequence set forth in SEQ ID NO: 15; and (j) a light chain variable region (VL) comprising: i) a CDRL1 domain comprising the sequence set forth in SEQ ID NO: 16; ii) a CDRL2 domain comprising the sequence set forth in SEQ ID NO: 18; iii) a CDRL3 domain comprising the sequence set forth in SEQ ID NO: 20; or (k) a heavy chain variable region (VH) comprising; i) a CDRH1 domain comprising the sequence set forth in SEQ ID NO: 9; ii) a CDRH2 domain comprising the sequence set forth in SEQ ID NO: 11; iii) a CDRH3 domain comprising the sequence set forth in SEQ ID NO: 15; and (l) a light chain variable region (VL) comprising: i) a CDRL1 domain comprising the sequence set forth in SEQ ID NO: 17; ii) a CDRL2 domain comprising the sequence set forth in SEQ ID NO: 18; iii) a CDRL3 domain comprising the sequence set forth in SEQ ID NO: 20; or (m) a heavy chain variable region (VH) comprising; i) a CDRH1 domain comprising the sequence set forth in SEQ ID NO: 9; ii) a CDRH2 domain comprising the sequence set forth in SEQ ID NO: 11; iii) a CDRH3 domain comprising the sequence set forth in SEQ ID NO: 15; and (n) a light chain variable region (VL) comprising: i) a CDRL1 domain comprising the sequence set forth in SEQ ID NO: 16; ii) a CDRL2 domain comprising the sequence set forth in SEQ ID NO: 19; iii) a CDRL3 domain comprising the sequence set forth in SEQ ID NO: 20; or (o) a heavy chain variable region (VH) comprising; i) a CDRH1 domain comprising the sequence set forth in SEQ ID NO: 9; ii) a CDRH2 domain comprising the sequence set forth in SEQ ID NO: 11; iii) a CDRH3 domain comprising the sequence set forth in SEQ ID NO: 15; and (p) a light chain variable region (VL) comprising: i) a CDRL1 domain comprising the sequence set forth in SEQ ID NO: 17; ii) a CDRL2 domain comprising the sequence set forth in SEQ ID NO: 19; iii) a CDRL3 domain comprising the sequence set forth in SEQ ID NO: 20; or (q) a heavy chain variable region (VH) comprising; i) a CDRH1 domain comprising the sequence set forth in SEQ ID NO: 9; ii) a CDRH2 domain comprising the sequence set forth in SEQ ID NO: 12; iii) a CDRH3 domain comprising the sequence set forth in SEQ ID NO: 15; and (r) a light chain variable region (VL) comprising: i) a CDRL1 domain comprising the sequence set forth in SEQ ID NO: 16; ii) a CDRL2 domain comprising the sequence set forth in SEQ ID NO: 18; iii) a CDRL3 domain comprising the sequence set forth in SEQ ID NO: 20; or (s) a heavy chain variable region (VH) comprising; i) a CDRH1 domain comprising the sequence set forth in SEQ ID NO: 9; ii) a CDRH2 domain comprising the sequence set forth in SEQ ID NO: 12; iii) a CDRH3 domain comprising the sequence set forth in SEQ ID NO: 15; and (t) a light chain variable region (VL) comprising: i) a CDRL1 domain comprising the sequence set forth in SEQ ID NO: 17; ii) a CDRL2 domain comprising the sequence set forth in SEQ ID NO: 18; iii) a CDRL3 domain comprising the sequence set forth in SEQ ID NO: 20; or (u) a heavy chain variable region (VH) comprising; i) a CDRH1 domain comprising the sequence set forth in SEQ ID NO:9; ii) a CDRH2 domain comprising the sequence set forth in SEQ ID NO: 12; iii) a CDRH3 domain comprising the sequence set forth in SEQ ID NO: 15; and (v) a light chain variable region (VL) comprising: i) a CDRL1 domain comprising the sequence set forth in SEQ ID NO: 16; ii) a CDRL2 domain comprising the sequence set forth in SEQ ID NO: 19; iii) a CDRL3 domain comprising the sequence set forth in SEQ ID NO: 20; or (w) a heavy chain variable region (VH) comprising; i) a CDRH1 domain comprising the sequence set forth in SEQ ID NO: 9; ii) a CDRH2 domain comprising the sequence set forth in SEQ ID NO: 12; iii) a CDRH3 domain comprising the sequence set forth in SEQ ID NO: 15; and (x) a light chain variable region (VL) comprising: i) a CDRL1 domain comprising the sequence set forth in SEQ ID NO: 17; ii) a CDRL2 domain comprising the sequence set forth in SEQ ID NO: 19; iii) a CDRL3 domain comprising the sequence set forth in SEQ ID NO: 20; or (y) a heavy chain variable region (VH) comprising; i) a CDRH1 domain comprising the sequence set forth in SEQ ID NO: 9; ii) a CDRH2 domain comprising the sequence set forth in SEQ ID NO: 13; iii) a CDRH3 domain comprising the sequence set forth in SEQ ID NO: 15; and (z) a light chain variable region (VL) comprising: i) a CDRL1 domain comprising the sequence set forth in SEQ ID NO: 16; ii) a CDRL2 domain comprising the sequence set forth in SEQ ID NO: 18; iii) a CDRL3 domain comprising the sequence set forth in SEQ ID NO: 20; or (aa) a heavy chain variable region (VH) comprising; i) a CDRH1 domain comprising the sequence set forth in SEQ ID NO:9; ii) a CDRH2 domain comprising the sequence set forth in SEQ ID NO: 13; iii) a CDRH3 domain comprising the sequence set forth in SEQ ID NO: 15; and (ab) a light chain variable region (VL) comprising: i) a CDRL1 domain comprising the sequence set forth in SEQ ID NO: 17; ii) a CDRL2 domain comprising the sequence set forth in SEQ ID NO: 18; iii) a CDRL3 domain comprising the sequence set forth in SEQ ID NO: 20; or (ad) a heavy chain variable region (VH) comprising; i) a CDRH1 domain comprising the sequence set forth in SEQ ID NO: 9; ii) a CDRH2 domain comprising the sequence set forth in SEQ ID NO: 13; iii) a CDRH3 domain comprising the sequence set forth in SEQ ID NO: 15; and (ae) a light chain variable region (VL) comprising: i) a CDRL1 domain comprising the sequence set forth in SEQ ID NO: 16; ii) a CDRL2 domain comprising the sequence set forth in SEQ ID NO: 19; iii) a CDRL3 domain comprising the sequence set forth in SEQ ID NO: 20; or (af) a heavy chain variable region (VH) comprising; i) a CDRH1 domain comprising the sequence set forth in SEQ ID NO: 9; ii) a CDRH2 domain comprising the sequence set forth in SEQ ID NO: 13; iii) a CDRH3 domain comprising the sequence set forth in SEQ ID NO: 15; and (ag) a light chain variable region (VL) comprising: i) a CDRL1 domain comprising the sequence set forth in SEQ ID NO: 17; ii) a CDRL2 domain comprising the sequence set forth in SEQ ID NO: 19; iii) a CDRL3 domain comprising the sequence set forth in SEQ ID NO: 20; or (ah) a heavy chain variable region (VH) comprising; i) a CDRH1 domain comprising the sequence set forth in SEQ ID NO: 9; ii) a CDRH2 domain comprising the sequence set forth in SEQ ID NO: 13; iii) a CDRH3 domain comprising the sequence set forth in SEQ ID NO: 15; and (ai) a light chain variable region (VL) comprising: i) a CDRL1 domain comprising the sequence set forth in SEQ ID NO: 17; ii) a CDRL2 domain comprising the sequence set forth in SEQ ID NO: 19; iii) a CDRL3 domain comprising the sequence set forth in SEQ ID NO: 20; or (aj) a heavy chain variable region (VH) comprising; i) a CDRH1 domain comprising the sequence set forth in SEQ ID NO: 9; ii) a CDRH2 domain comprising the sequence set forth in SEQ ID NO: 14; iii) a CDRH3 domain comprising the sequence set forth in SEQ ID NO: 15; and (ak) a light chain variable region (VL) comprising: i) a CDRL1 domain comprising the sequence set forth in SEQ ID NO: 16; ii) a CDRL2 domain comprising the sequence set forth in SEQ ID NO: 18; iii) a CDRL3 domain comprising the sequence set forth in SEQ ID NO: 20; or (al) a heavy chain variable region (VH) comprising; i) a CDRH1 domain comprising the sequence set forth in SEQ ID NO: 9; ii) a CDRH2 domain comprising the sequence set forth in SEQ ID NO: 14; iii) a CDRH3 domain comprising the sequence set forth in SEQ ID NO: 15; and (am) a light chain variable region (VL) comprising: i) a CDRL1 domain comprising the sequence set forth in SEQ ID NO: 17; ii) a CDRL2 domain comprising the sequence set forth in SEQ ID NO: 18; iii) a CDRL3 domain comprising the sequence set forth in SEQ ID NO: 20; or (an) a heavy chain variable region (VH) comprising; i) a CDRH1 domain comprising the sequence set forth in SEQ ID NO: 9; ii) a CDRH2 domain comprising the sequence set forth in SEQ ID NO: 14; iii) a CDRH3 domain comprising the sequence set forth in SEQ ID NO: 15; and (ao) a light chain variable region (VL) comprising: i) a CDRL1 domain comprising the sequence set forth in SEQ ID NO: 16; ii) a CDRL2 domain comprising the sequence set forth in SEQ ID NO: 19; iii) a CDRL3 domain comprising the sequence set forth in SEQ ID NO: 20; or (ap) a heavy chain variable region (VH) comprising; i) a CDRH1 domain comprising the sequence set forth in SEQ ID NO: 9; ii) a CDRH2 domain comprising the sequence set forth in SEQ ID NO: 14; iii) a CDRH3 domain comprising the sequence set forth in SEQ ID NO: 15; and (aq) a light chain variable region (VL) comprising: i) a CDRL1 domain comprising the sequence set forth in SEQ ID NO: 17; ii) a CDRL2 domain comprising the sequence set forth in SEQ ID NO: 19; iii) a CDRL3 domain comprising the sequence set forth in SEQ ID NO: 20.
  3. 3 . The isolated antibody or antigen-binding fragment thereof of claim 1 , wherein the antibody or antigen binding fragment comprises an Fc region and the Fc region has been engineered to reduce or eliminate one or more Fc effector function.
  4. 4 . The isolated antibody or antigen-binding fragment thereof of claim 3 , wherein the one or more Fc effector function is FcR binding or complement binding.
  5. 5 . The isolated antibody or antigen-binding fragment thereof of claim 1 , wherein the antibody is an IgG1 isotype, and wherein the antibody comprises a heavy chain constant region that comprises the amino acid sequence as set forth in SEQ ID NO: 21.
  6. 6 . The isolated antibody or antigen-binding fragment thereof of claim 1 , further comprising a heavy chain constant region, wherein the heavy chain constant region comprises the amino acid sequence as set forth in SEQ ID NO: 22.
  7. 7 . The isolated antibody or antigen-binding fragment thereof of claim 1 , further comprising a heavy chain constant region, wherein the heavy chain constant region comprises the amino acid sequence as set forth in SEQ ID NO: 23.
  8. 8 . The isolated antibody or antigen-binding fragment thereof of claim 1 , further comprising a heavy chain constant region, wherein the heavy chain constant region comprises the amino acid sequence as set forth in SEQ ID NO: 24.
  9. 9 . The isolated antibody or antigen-binding fragment thereof of claim 1 , wherein the antibody further comprises a light chain constant region, wherein the light chain constant region comprises the amino acid sequence set forth in SEQ ID NO: 25.
  10. 10 . The isolated antibody or antigen-binding fragment thereof of claim 1 , wherein the antibody comprises: (a) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 46 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 38; or (b) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 46 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 39: or (c) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 46 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 40: or (d) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 46 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 41; or (e) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 47 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 38; or (f) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 47 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 39: or (g) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 47 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 40: or (h) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 47 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 41; or (i) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 48 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 38; or (j) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 48 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 39: or (k) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 48 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 40: or (l) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 48 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 41; or (m) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 49 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 38; or (n) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 49 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 39: or (o) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 49 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 40: or (p) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 49 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 41.
  11. 11 . The isolated antibody or antigen-binding fragment thereof of claim 1 , wherein the antibody comprises: (a) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 50 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 38; or (b) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 50 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 39: or (c) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 50 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 40: or (d) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 50 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 41; or (e) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 51 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 38; or (f) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 51 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 39: or (g) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 51 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 40: or (h) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 51 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 41; or (i) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 52 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 38; or (j) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 52 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 39: or (k) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 52 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 40: or (l) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 52 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 41; or (m) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 53 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 38; or (n) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 53 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 39: or (o) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 53 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 40: or (p) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 53 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 41.
  12. 12 . The isolated antibody or antigen-binding fragment thereof of claim 1 , wherein the antibody comprises: (a) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 54 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 38; or (b) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 54 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 39: or (c) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 54 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 40: or (d) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 54 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 41; or (e) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 55 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 38; or (f) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 55 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 39: or (g) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 55 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 40: or (h) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 55 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 41; or (i) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 56 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 38; or (j) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 56 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 39: or (k) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 56 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 40: or (l) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 56 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 41; or (m) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 57 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 38; or (n) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 57 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 39: or (o) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 57 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 40: or (p) a heavy chain having the amino acid sequence as set forth in SEQ ID NO: 57 and the light chain having the amino acid sequence as set forth in SEQ ID NO: 41.
  13. 13 . A method for treating a subject with a neurodegenerative or a neuromuscular disease or disorder; an inflammatory or immune disease or disorder; or an autoimmune disease, comprising administering to the subject a therapeutically effective amount of an antibody or antigen-binding fragment thereof of claim 1 .
  14. 14 . The method of claim 13 , wherein the autoimmune disease is selected from the group consisting of systemic lupus erythematous, type-1 diabetes, Myasthenia gravis, psoriasis, Addison's disease, Crohn's disease, uveitis, multiple sclerosis, hemolytic anemia, inflammatory bowel disease, immune thrombocytopenia purpura, Graves' disease, and rheumatoid arthritis.
  15. 15 . The method of claim 13 , wherein the neurodegenerative disorder or a neuromuscular disorder is selected from the group consisting of Alzheimer's Disease, Parkinson's Disease, Amyotrophic Lateral Sclerosis, Multifocal Motor Neuropathy, Primary Lateral Sclerosis, Spinal Muscular Atrophy, Kennedy's Disease, or Spinocerebellar Ataxia.
  16. 16 . The method of claim 13 , wherein the neurodegenerative disease or disorder is Amyotrophic Lateral Sclerosis.
  17. 17 . A method of inhibiting an immune response in a subject comprising administering to the subject a therapeutically effective amount of an antibody or antigen-binding fragment thereof of claim 1 .
  18. 18 . The method of claim 17 , wherein the immune response is graft vs. host disease, or organ transplant rejection.
  19. 19 . The method of claim 17 , wherein the antibody or antigen-binding fragment thereof is administered in combination with another therapeutic agent.
  20. 20 . The method of claim 19 , wherein the antibody or antigen-binding fragment thereof is administered in combination with a compound that blocks the interaction between CD28 and CD86 or between CD28 and CD80.

Description

CROSS REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. application Ser. No. 16/615,757, filed Nov. 21, 2019, which is a 35 U.S.C. § 371 United States National Phase Application of, and claims priority to PCT Application No. PCT/US2018/034172, filed May 23, 2018, which claims priority to U.S. Provisional Application No. 62/510,471, filed May 24, 2017. The entire contents of the aforementioned disclosures are incorporated by reference. SEQUENCE LISTING This application incorporates by reference in its entirety the sequence listing entitled “SeqListing_ELDN008C1.XML” created on Nov. 20, 2019, at 3:15 pm, that is 84,560 bytes in size, and filed electronically herewith. FIELD Anti-CD40L antibodies, compositions comprising the antibodies, and method of using same for treatment of CD40L-related diseases or disorders. BACKGROUND The interaction of CD40 with its ligand CD40L plays a critical role in regulating immune responses. Binding of CD40L to CD40 triggers activation of the CD40 pathway which up-regulates costimulatory molecules such as CD80 and CD86. Blockade of the interaction between CD40 and CD40L by monoclonal antibodies has been shown to result in protection from autoimmunity and graft rejection in various preclinical models. Recently, in a mouse model of amyotrophic lateral sclerosis, an antibody directed to CD40L was shown to delay disease onset and prolong survival the onset of disease. (U.S. Pat. No. 8,435,514, hereby incorporated by reference). In early clinical studies, the humanized anti-CD40L antibody hu5c8 showed efficacy in patients with lupus and in patients with immune thrombocytopenic purpura. However, incidents of thromboembolism in the patients treated with hu5c8 halted further trials. Further in vitro and preclinical animal studies established that interaction of the Fc with the Fc receptor FcγRIIa caused platelet activation, and aggregation, that resulted in thromboembolic events. In addition, it has been reported that binding of the Fc to complement may reduce or prevent induction of immune tolerance. Various approaches have been taken to reduce or eliminate the interaction of the immunoglobulin Fc region with FcγRIIa, and/or to reduce or eliminate the interaction with complement, including introducing point mutation(s) in the Fc region to make anti-CD40L antibodies which lack Fc effector function. Other approaches use fragments of antibodies lacking the Fc region or antibodies that contain multiple amino acid substitutions in the Fc region. Although the anti-CD40L antibody, hu5c8, showed efficacy in human patients there is no anti-CD40L antibody on the market. Accordingly, there is a need for improved anti-CD40L antibodies for administration to humans that are efficacious and do not cause platelet activation or aggregation or bind to complement yet are stable and bind to CD40L. SUMMARY Novel antibody polypeptides and antigen binding fragments thereof, of the present invention provide such improved anti-CD40L antibodies. The following section only summarizes certain aspects of the present disclosure and is not intended to be limiting in nature. These aspects and other aspects and embodiments are described more fully below. All references cited in this specification are hereby incorporated by reference in their entirety. In the event of a discrepancy between the express disclosure of this specification and the references incorporated by reference, the express disclosure of this specification shall control. The present invention provides isolated, engineered, non-naturally occurring antibodies and antigen binding fragments thereof, that bind human CD40L and block the binding of CD40 to CD40L. The antibody and antigen binding fragments thereof, are engineered to have the desired activity and binding. In some embodiments the antibody or antigen binding fragment thereof, are engineered to have decreased Fc effector function in comparison to some previous anti-CD40L antibodies. The antibodies and antigen binding fragments thereof as disclosed in the present application are useful in the treatment of diseases involving CD40L activation, including neurodegenerative or neuromuscular diseases or disorders, inflammatory or immune diseases or disorders and autoimmune diseases. In one aspect the present disclosure provides isolated antibodies or antigen-binding fragments thereof that specifically binds to CD40L which comprise: (a) a heavy chain variable region (VH) comprising; i) a CDRH1 domain comprising the sequence set forth in SEQ ID NO: 9; ii) a CDRH2 domain comprising the sequence set forth in SEQ ID NO: 10, 11, 12, 13, or 14; iii) a CDRH3 domain comprising the sequence set forth in SEQ ID NO: 15; and (b) a light chain variable region (VL) comprising: i) a CDRL1 domain comprising the sequence set forth in SEQ ID NO: 16 or 17; ii) a CDRL2 domain comprising the sequence set forth in SEQ ID NO: 18 or 19; and iii) a CDRL3 domain comprising the sequence set forth in SEQ I