US-12620461-B2 - Visual interface for generation of groups and experiment building

Abstract

A user interface that includes a plate map that automatically updates to provide indicia descriptive of parameter assignments and parameter groups can provide an intuitive system for building experiments. For example, a user may provide one or more inputs to generate and assign a parameter setting to a plurality of cells that represent a plurality of wells. The user interface may update the plate map to depict one or more indicia to indicate which wells have been assigned the new parameter setting.

Inventors

• Joshua Cooper
• Benjamin Paradis

Assignees

• AGILENT TECHNOLOGIES, INC.

Dates

Publication Date

20260505

Application Date

20220614

Claims (20)

1. 1 . A computer-implemented method for setting parameters for an experiment, the method comprising: providing, by a computing system comprising one or more processors, a plate experiment interface for display, wherein the plate experiment interface comprises a plate map; receiving, by the computing system, one or more inputs to generate a new parameter setting; generating, by the computing system, the new parameter setting based on the one or more inputs; receiving, by the computing system, one or more selections to assign the new parameter setting to one or more wells represented in the plate map; and providing, by the computing system, an updated plate experiment interface for display, wherein the one or more wells are displayed with a first indicia to indicate a first grouping, wherein the updated plate experiment interface comprises character indicia associated with parameter assignments associated with a selected parameter tab of a plurality of parameter tabs, and wherein the updated plate experiment interface comprises color indicia descriptive of groupings associated with parameters setting differences between groups of wells; receiving a selection input to begin an experiment; and controlling one or more instruments based at least in part on the new parameter setting and the selection input.
2. 2 . The computer-implemented method of claim 1 , wherein the one or more wells are displayed with a first character to indicate the one or more wells are assigned the new parameter setting.
3. 3 . The computer-implemented method of claim 1 , further comprising: adjusting, by the computing system, a parameter setting for each of the one or more wells based at least in part on the new parameter setting.
4. 4 . The computer-implemented method of claim 1 , further comprising: receiving, by the computing system, one or more finalization selections from a user to finalize the new parameter setting; and providing, by the computing system, a finalization interface for display, wherein the finalization interface comprises an updated plate map and group information descriptive of a set of parameter settings for each respective grouping.
5. 5 . The computer-implemented method of claim 1 , further comprising: receiving, by the computing system, a new tab selection from a user; and removing, by the computing system, a first indicia from the updated plate experiment interface.
6. 6 . The computer-implemented method of claim 1 , wherein the plate experiment interface comprises the plurality of parameter tabs, wherein each tab is associated with a different display of the plate map.
7. 7 . The computer-implemented method of claim 6 , wherein the plurality of parameter tabs comprise an injection strategy setting tab, a pretreatment setting tab, an assay media setting tab, and a cell type setting tab.
8. 8 . The computer-implemented method of claim 6 , wherein the plurality of parameter tabs comprise a finalization tab, wherein the finalization tab is associated with a fully-configured plate map.
9. 9 . The computer-implemented method of claim 1 , wherein the new parameter setting is at least one of an injection strategy setting, a pretreatment setting, an assay media setting, or a cell type setting.
10. 10 . The computer-implemented method of claim 1 , further comprising: receiving, by the computing system, one or more second inputs to generate a second parameter setting; generating, by the computing system, the second parameter setting based on the one or more second inputs; receiving, by the computing system, one or more selections to assign the second parameter setting to a subset of the one or more wells represented in the plate map; and providing, by the computing system, an adjusted plate experiment interface for display, wherein the subset of the one or more wells are displayed with a second color to indicate a second grouping, and wherein the subset of the one or more wells are displayed with a second character to indicate the subset of the one or more wells are assigned the second parameter setting.
11. 11 . The computer-implemented method of claim 10 , further comprising: receiving, by the computing system, secondary input data associated with a second parameter setting; generating, by the computing system, a second grouping with the second parameter setting; providing, by the computing system, group information associated with the first grouping and the second grouping for display in the updated plate experiment interface; determining, by the computing system, the second grouping is without assignment on the plate map; and removing, by the computing system, a subset of the group information from the updated plate experiment interface, wherein the subset is associated with the second grouping.
12. 12 . A computing system, the computing system comprising: one or more processors; one or more non-transitory computer readable media that collectively store instructions that, when executed by the one or more processors, cause the computing system to perform operations, the operations comprising: receiving one or more inputs to generate a parameter setting; generating the parameter setting based on the one or more inputs; receiving a selection of one or more samples for parameter assignment; assigning the parameter setting to the one or more samples; providing a plate map for display, wherein a portion of the plate map representing the one or more samples is displayed with one or more indicia, wherein the plate map comprises character indicia associated with parameter assignments associated with a selected parameter tab of a plurality of parameter tabs, and wherein the plate map comprises color indicia descriptive of groupings associated with parameters setting differences between groups of wells; receiving a selection input to begin an experiment; and controlling one or more instruments based at least in part on the parameter setting and the selection input.
13. 13 . The computing system of claim 12 , wherein the plate map comprises at least 96 samples.
14. 14 . The computing system of claim 12 , wherein the operations further comprise: providing a groups column for display, wherein the groups column is displayed simultaneously with the plate map, and wherein the groups column comprises group information.
15. 15 . The computing system of claim 12 , wherein the operations further comprise: providing a parameter column for display, wherein the parameter column is displayed simultaneously with the plate map, and wherein the parameter column comprises a title descriptive of a parameter type and one or more assignment-ready parameters, wherein the one or more assignment-ready parameters comprise the parameter setting.
16. 16 . The computing system of claim 12 , wherein the indicia comprises a first indicia descriptive of the parameter setting and a second indicia descriptive of a well grouping.
17. 17 . An experiment computing system, the experiment system comprising: a plate comprising a plurality of wells; one or more injection instruments; one or more visual displays for displaying visual components of a user interface; one or more input components configured to receive inputs from a user; one or more processors; one or more non-transitory computer readable media that collectively store instructions that, when executed by the one or more processors, cause the experiment computing system to perform operations, the operations comprising: receiving one or more inputs to generate a parameter setting; generating the parameter setting based on the one or more inputs; receiving a selection of one or more wells for parameter assignment; assigning the parameter setting to the one or more wells; providing a plate map for display with the one or more visual displays, wherein a portion of the plate map representing the one or more wells is displayed with a plurality of indicia, wherein the plate map comprises character indicia associated with parameter assignments associated with a selected parameter tab of a plurality of parameter tabs, and wherein the plate map comprises color indicia descriptive of groupings associated with parameters setting differences between groups of wells; receiving a selection input to begin an experiment; and controlling one or more injection instruments based at least in part on the parameter setting and the selection input.
18. 18 . The experiment computing system of claim 17 , wherein the one or more injection instruments comprises a plurality of injection ports for injecting a plurality of compounds.
19. 19 . The experiment computing system of claim 17 , further comprising: one or more pretreatment instruments.
20. 20 . The experiment computing system of claim 19 , wherein the operations further comprise: receiving one or more second inputs to generate a second parameter setting; generating the second parameter setting based on the one or more second inputs; receiving a second selection of a second set of one or more wells for a second parameter assignment; assigning the second parameter setting to the second set of one or more wells; and controlling the one or more pretreatment instruments based at least in part on the second parameter setting and the selection input.

Description

RELATED APPLICATIONS This application claims priority to and the benefit of U.S. Provisional Patent Application No. 63/211,240, filed Jun. 16, 2021. U.S. Provisional Patent Application No. 63/211,240 is hereby incorporated by reference in its entirety. FIELD The present disclosure relates generally to a user interface for configuring plate experiments. More particularly, the present disclosure relates to systems and methods for providing a plate experiment interface for receiving inputs to generate a plate map that can aid in plate experimentation. BACKGROUND For assay experiments, users often need to enter data for plates that may have many wells. Some existing solutions can rely on entering parameters as data into a spreadsheet. The method can require a user to manually enter repetitive parameter data into fields. The grouping of wells can also be completed manually. A couple disadvantages of the method can be that the method takes much longer and can be more susceptible to user errors. Moreover, other existing systems can rely on a user first creating a group and manually configuring the groups before assigning the parameters to the wells. The existing systems can involve tedious input, which can be inefficient and conducive to errors. Moreover, the existing systems can discourage users from adding more detailed parameter data, resulting in sparsely detailed assay designs. Furthermore, the existing systems can cause problems downstream in the workflow including reduced instrument usage, data reproducibility problems, and delayed discoveries. SUMMARY Aspects and advantages of embodiments of the present disclosure will be set forth in part in the following description, or can be learned from the description, or can be learned through practice of the embodiments. One example aspect of the present disclosure is directed to a computer-implemented method for setting parameters for an experiment. The method can include providing, by a computing system including one or more processors, a plate experiment interface for display. In some implementations, the plate experiment interface can include a plate map. The method can include receiving, by the computing system, one or more inputs to generate a new parameter setting. The method can include generating, by the computing system, the new parameter setting based on the one or more inputs. The method can include receiving, by the computing system, one or more selections to assign the new parameter setting to one or more wells represented in the plate map. In some implementations, the method can include providing, by the computing system, an updated plate experiment interface for display. The one or more wells can be displayed with a first indicia to indicate a first grouping. In some implementations, the one or more wells can be displayed with a first character to indicate the one or more wells are assigned the new parameter setting. The method can include adjusting, by the computing system, a parameter setting for each of the one or more wells based at least in part on the new parameter setting. The method can include receiving, by the computing system, one or more finalization selections from a user to finalize the new parameter setting and providing, by the computing system, a finalization interface for display. In some implementations, the finalization interface can include an updated plate map and group information descriptive of a set of parameter settings for each respective grouping. The method can include receiving, by the computing system, a new tab selection from a user and removing, by the computing system, a first indicia from the updated plate experiment interface. In some implementations, the plate experiment interface can include a plurality of tabs, and each tab can be associated with a different display of the plate map. The plurality of tabs can include an injection strategy setting tab, a pretreatment setting tab, an assay media setting tab, and a cell type setting tab. In some implementations, the plurality of tabs can include a finalization tab, and the finalization tab can be associated with a fully-configured plate map. The new parameter setting can be at least one of an injection strategy setting, a pretreatment setting, an assay media setting, or a cell type setting. In some implementations, the method can include receiving, by the computing system, one or more second inputs to generate a second parameter setting; generating, by the computing system, the second parameter setting based on the one or more second inputs; receiving, by the computing system, one or more selections to assign the second parameter setting to a subset of the one or more wells represented in the plate map; and providing, by the computing system, an adjusted plate experiment interface for display. The subset of the one or more wells can be displayed with a second color to indicate a second grouping, and the subset of the one or more wells can be displayed with a secon