US-12622701-B2 - Multi-sectional implant for vascular treatment

Abstract

An implant for vascular treatment may include a wire having three or more sections, with adjacent sections having different stiffnesses and/or other properties to facilitate treating an aneurysm with a single instance of the wire. As compared to treating aneurysms using multiple coils, the wire having three or more sections may reduce the time required for treatment of the aneurysm.

Inventors

• Ujwal Jalgaonkar
• Ryan Solomon
• Stephanie Gong

Assignees

• BALT USA, LLC

Dates

Publication Date

20260512

Application Date

20240729

Claims (16)

1. 1 . An implant for vascular treatment, the implant comprising: a wire having a first section, a second section, and a third section movable from a delivery state to a deployed state in response to removal of external pressure on the wire, in the delivery state, the first section, the second section, and the third section collectively defining a longitudinal axis with the second section longitudinally disposed between the first section and third section, the second section of the wire having stiffness differing from respective stiffnesses of the first section and the third section, and in the deployed state, the first section securable to a target anatomical location of a subject with the first section defining a first volume and the second section packable into the first volume to occupy at least a portion of an anatomical vessel of the subject, wherein the second section is less stiff than the first section and is stiffer than the third section.
2. 2 . The implant of claim 1 , wherein, in the deployed state and in the absence of external pressure, the first volume of the first section is in the shape of a box.
3. 3 . The implant of claim 1 , wherein, in the deployed state, the second section is packable into the first volume of the first section with the second section defining a second volume, and the third section is packable into the second volume of the second section within the first volume of the first section.
4. 4 . The implant of claim 1 , wherein the first section is positionable with the volume disposed in an aneurysm of the anatomical vessel, and the third section is a packable into a neck of the aneurysm.
5. 5 . The implant of claim 1 , wherein, in the delivery state, the first section is longer than the second section, and the second section is longer than the third section.
6. 6 . The implant of claim 1 , wherein, in the deployed state, the first section includes at least one loop defining the volume.
7. 7 . The implant of claim 1 , wherein the second section has a proximal region and a distal region, the first section is coupled to the distal region of the second section at a first stress transition zone, the third section is coupled to the proximal region of the second section at a second stress transition zone.
8. 8 . The implant of claim 7 , wherein at least one of the first stress transition zone or the second stress transition zone includes a weld.
9. 9 . The implant of claim 7 , wherein at least one of the first stress transition zone or the second stress transition zone includes glue, thread, or a combination thereof.
10. 10 . The implant of claim 7 , wherein the wire has a wire diameter varying between at least two of the first section, the second section, or the third section.
11. 11 . The implant of claim 7 , wherein the wire includes primary windings along at least one of the first section, the second section, and the third section.
12. 12 . The implant of claim 11 , wherein, in absence of external pressure on the primary windings, an outer diameter of the primary windings varies between at least two of the first section, the second section, or the third section.
13. 13 . The implant of claim 11 , wherein the primary windings define gaps therebetween, and the size of the gaps of the primary windings vary between at least two of the first section, the second section, or the third section.
14. 14 . The implant of claim 1 , wherein modulus of rigidity of the wire varies between at least two of the first section, the second section, or the third section.
15. 15 . An implant for vascular treatment, the implant comprising: a wire having a first section, a second section, and a third section movable from a delivery state to a deployed state in response to removal of external pressure on the wire, in the delivery state, the first section, the second section, and the third section collectively defining a longitudinal axis with the second section longitudinally disposed between the first section and third section, the second section of the wire having stiffness differing from respective stiffnesses of the first section and the third section, and in the deployed state, the first section securable to a target anatomical location of a subject with the first section defining a first volume and the second section packable into the first volume to occupy at least a portion of an anatomical vessel of the subject, wherein the second section has a proximal region and a distal region, the first section is coupled to the distal region of the second section at a first stress transition zone, the third section is coupled to the proximal region of the second section at a second stress transition zone, further comprising a sleeve crimped to the second section and at least one of the first section along the first stress transition zone or the third section along the second stress transition zone.
16. 16 . An implant for vascular treatment, the implant comprising: a wire having a first section, a second section, and a third section movable from a delivery state to a deployed state in response to removal of external pressure on the wire, in the delivery state, the first section, the second section, and the third section collectively defining a longitudinal axis with the second section longitudinally disposed between the first section and third section, the second section of the wire having stiffness differing from respective stiffnesses of the first section and the third section, and in the deployed state, the first section securable to a target anatomical location of a subject with the first section defining a first volume and the second section packable into the first volume to occupy at least a portion of an anatomical vessel of the subject, further comprising a fourth section wherein, in the delivery state, the third section is disposed between the second section and the fourth section, and the fourth section is softer than the third section.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS This application claims priority to and the benefit of U.S. Provisional Patent Application No. 63/516,235, filed on Jul. 28, 2023, the entire contents of which are hereby incorporated herein by reference. BACKGROUND Implantable medical devices can be used to treat a number of diseases and conditions associated with body lumens. For instance, weakening in the arterial wall can develop into vascular aneurysms and, ultimately, can lead to internal bleeding and/or other conditions. Implant devices can be used to occlude vessels, aneurysms, and other anatomical spaces to treat such potentially dangerous conditions and/or for vessel sacrifice. For example, implant devices can be used to obstruct (e.g., completely or partially) the flow in a blood vessel, such as, a location peripheral or adjacent to an aneurysm or other vascular abnormality. However, the time associated with accurate and stable placement of such implant devices at a treatment site is often critical. Accordingly, there is a need for implant devices that can be quickly and reliably placed for occlusion of vessels, aneurysms, and other anatomical locations. SUMMARY An implant for vascular treatment may include a wire having three or more sections, with adjacent sections having different stiffnesses and/or other properties to facilitate treating an aneurysm with a single instance of the wire. As compared to treating aneurysms using multiple coils, the wire having three or more sections may reduce the time required for treatment of the aneurysm. According to an aspect, an implant for vascular treatment may include a wire having a first section, a second section, and a third section movable from a delivery state to a deployed state in response to removal of external pressure on the wire. In the delivery state, the first section, the second section, and the third section may collectively define a longitudinal axis with the second section longitudinally disposed between the first section and third section, and the second section of the wire may have stiffness differing from respective stiffnesses of the first section and the third section. In the deployed state, the first section may be securable to a target anatomical location of a subject with the first section defining a first volume and at least the second section packable into the first volume to occupy at least a portion of an anatomical vessel of the subject. In certain implementations, the second section may be less stiff than the first section and is stiffer than the third section. In some implementations, in the deployed state and in the absence of external pressure, the first volume of the first section may be in the shape of a box. In certain implementations, in the deployed state, the second section may be packable into the first volume of the first section with the second section defining a second volume, and the third section is packable into the second volume of the second section within the first volume of the first section. In some implementations, the first section may be positionable with the volume disposed in an aneurysm of the anatomical vessel, and the third section is a packable into a neck of the aneurysm. In certain implementations, in the delivery state, the first section may be longer than the second section, and the second section is longer than the third section. In some implementations, in the deployed state, the first section may include at least one loop defining the volume. In certain implementations, the second section may have a proximal region and a distal region, the first section is coupled to the distal region of the second section at a first stress transition zone, the third section is coupled to the proximal region of the second section at a second stress transition zone. As an example, at least one of the first stress transition zone or the second stress transition zone may include a weld. Further, or instead, the implant may further include a sleeve crimped to the second section and at least one of the first section along the first stress transition zone or the third section along the second stress transition zone. Additionally, or alternatively, at least one of the first stress transition zone or the second stress transition zone may include glue, thread, or a combination thereof. Still further, or instead, the wire may have a wire diameter varying between at least two of the first section, the second section, or the third section. In certain instances, the wire may include primary windings along at least one of the first section, the second section, and the third section. As an example, in absence of external pressure on the primary windings, an outer diameter of the primary windings varies between at least two of the first section, the second section, or the third section. Additionally, or alternatively, the primary windings may define gaps therebetween, and the size of the gaps of the primary windings vary between at