US-12622769-B2 - Dental implant container and an implant

Abstract

The present invention refers to a temperature resistant dental implant container with dental implant comprising a polygonal or cylindrical, optically transparent container with a conically tapered interior for receiving a dental implant, a needle-pierceable, flexible, and liquid-tight septum, a lid which is separably connected to the container, wherein the interior of the container is configured to fix the position of the dental implant between the bottom of the septum and the bottom of the interior, and a dental implant comprising a conditioned surface. Further its use for transport and storage, and a method for in vitro cellular coating a dental implant are described.

Inventors

• Eva-Kathrin Ehmoser
• Seta KÜPCÜ
• Mark Kettner

Assignees

• UNIVERSITÄT FÜR BODENKULTUR WIEN

Dates

Publication Date

20260512

Application Date

20230519

Priority Date

20220519

Claims (17)

1. 1 . A cell culture-compatible dental implant container resistant to temperatures of 100° C. and higher with a dental implant, comprising: a cylindrical, optically transparent container with a conically tapered interior for receiving a dental implant, a needle-pierceable, flexible, and liquid-tight septum, a lid which is separably connected to the container, wherein the interior of the container is configured to fix the position of the dental implant between the bottom of the septum and the bottom of the interior, and the dental implant, wherein the dental implant is made of a ceramic, plastic, or a polymeric material and is doted by or comprises a noble metal for self-assembly with one or more cell adhesion motifs, peptides, proteins and/or glycoproteins.
2. 2 . The dental implant container according to claim 1 , characterized in that the dental implant is made of bioceramic.
3. 3 . The dental implant container according to claim 1 , characterized in that the noble metal is doted into the dental implant.
4. 4 . The dental implant container according to claim 3 , characterized in that the noble metal is doted into the dental implant before sintering.
5. 5 . The dental implant container according to claim 3 , characterized in that the noble metal is doted into the dental implant by sputtering, electrothermal deposition, or chemical deposition.
6. 6 . The dental implant container according to claim 1 , wherein the noble metal is selected from the group consisting of platinum, titanium, gold, silver, and an alloy of one or more of platinum, titanium, gold, and silver.
7. 7 . The dental implant container according to claim 1 , characterized in that the noble metal provides binding sites, preferably for binding of proteins, cells or cell extracts, preferably bone-forming cells from blood, plasma, saliva, or tissue, specifically the proteins are selected from extracellular matrix proteins, specifically selected from the group consisting of RGD-peptides, specifically GRGDS, collagen, vitronectin, fibronectin, periostin, F-actin, paxillin, tropoelastin, focal adhesion kinase, integrin, tenascin C, and bone sialoprotein.
8. 8 . The dental implant container according to claim 1 , characterized in that the dental implant is a ceramic implant, further comprising or doted with titanium, zirconia, platinum, gold or silver molecules.
9. 9 . The dental implant container according to claim 8 , characterized in that the dental implant comprises sulfur molecules adhesively attached to the surface of said implant, specifically sulfur molecules adhesively attached to a titanium conditioned implant.
10. 10 . The dental implant container according to claim 1 , characterized in that the container is made of sterilizable glass or plastics.
11. 11 . The dental implant container according to claim 1 , characterized in that the lid is made of metal, optionally it has a twist lock or flare closure.
12. 12 . The dental implant container according to claim 1 , characterized in that the septum comprises an inner ring for insertion of the dental implant, allowing free access to the lateral surfaces of said implant.
13. 13 . The dental implant container according to claim 1 , characterized in that the septum is made of a material selected from the group consisting of silicone, PTFE, rubber, fluoroelastomer, and silicone.
14. 14 . The dental implant container according to claim 1 , characterized in that it can be sterilized, in particular by radiation, dry heat, wet sterilization, more specifically it can be sterilized two or more times.
15. 15 . A method for in vitro coating of a dental implant with cellular material inside a dental implant container, comprising the following sequential steps: a) introducing cellular material from a patient sample, wherein the cellular material is from blood, plasma, saliva, biopsy material, tissue or any cell extracts thereof, into the dental implant container according to claim 1 via the septum, and b) incubating the dental implant ( 5 ) with said cellular material, in the presence of a cell culture medium, further containing an antibiotic, under conditions to allow cell adhesion and growth on the implant surface.
16. 16 . The method according to claim 15 , characterized in that the cellular material is selected from the group consisting of proteins, cells, cell extracts, specifically the proteins are selected from extracellular matrix proteins, selected from the group consisting of collagen, vitronectin, fibronectin, periostin, F-actin, paxillin, tropoelastin, focal adhesion kinase, integrin, tenascin C, and bone sialoprotein.
17. 17 . The method according to claim 15 , wherein the dental implant is coated before or after sterilization.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS This application is the U.S. national stage of International Patent Application No. PCT/EP2023/063464, filed on May 19, 2023 and entitled IMPROVED DENTAL IMPLANT CONTAINER AND AN IMPLANT, which claims the benefit of priority under 35 U.S.C. § 119 from European Patent Application No. 22174267.9, filed on May 19, 2022. The disclosures of the foregoing applications are incorporated herein by reference in their entireties. SEQUENCE LISTING The entire content of a Sequence Listing titled “Sequence_Listing.xml,” created on Nov. 8, 2024 and having a size of 3 kilobytes, which has been submitted in electronic form in connection with the present application, is hereby incorporated by reference herein in its entirety. FIELD OF THE INVENTION The present invention refers to a temperature resistant dental implant container with dental implant comprising a polygonal or cylindrical volume and made by optically transparent material with a conically tapered interior for receiving a dental implant, a needle-pierceable, flexible, and liquid-tight septum, a lid which is separably connected to the container, wherein the interior of the container is configured to fix the position of the dental implant between the septum and the bottom of the interior, and a dental implant comprising a conditioned surface. Further its use for transport and storage, and a method for in vitro cellular coating a dental implant are described. BACKGROUND OF THE INVENTION An important factor in the storage and presentation of implants is to ensure the sterility of the implant arranged in a packaging sleeve. Transport containers for dental implants on the market are often blister packs made of coated paper or transparent polymer materials. These packages are filled with the implants, sealed (glued, or welded) and then sterilized via radioactive irradiation. Alternatively, transport containers for dental implants are provided, wherein the implants are secured to the container by specific means such as screws or specific holding elements which are connected to a tool for subsequent insertion of the implant into the human body (U.S. Pat. No. 5,368,160, EP1749501) or the container comprises mounting arrangements directly coupled to the implant (WO9965416). Dental implants are thus often not made available to dentists simply as the actual implants alone but rather are supplied from the outset as a unit with a mounting arrangement, which is let into an inner recess or outer connecting means of the implant. US2007/037123A1 describes a dental implant with a so-called Trulock™ indexing device. Further disclosed is a sterile disposable container for storing the implant, which is sealed with a pressed-in plastic cap. The implant is fixed at the top and bottom by an indentation at the bottom of the container. The plastic cap can also be used as a disposable rotator that is held in place with the fingers. US2018/318050A1 describes a device and a method for the treatment of an artificial bone implant with blood. US2001/031445A1 discloses a dental implant and operative method of implantation. KR2016 0007176A refers to an implant surface treated with gold particles. Jurczak P. et al., report proteins, peptides and peptidomimetics as active agents in implant surface functionalization (Advance in Colloid and Interface Science, 2019, 276, 1-21. US2007/202144A1 discloses coated devices. Ruoslahti E. discloses RGD and other recognition sequences for integrins (Annual Reviews, vol. 12, 1996, pp. 697-715). In addition to the requirements of safe transport and storage, there is also the need to pretreat implants before insertion in such a way that osseointegration is improved. However, this is a very critical step for the dentist or dental laboratory, because pretreating an implant, such as coating it with the patient's cells, involves the risk of microbial contamination and the risk that the cells do not sufficiently adhere to the implant surface. Therefore, there is a high and yet unmet need for providing a system for dental implants that enables safe transport and storage and allows sterile coating of a dental implant prior to insertion. SUMMARY OF THE INVENTION It is thus the objective of the present invention to provide a transport container which is not only sterilizable, but in which the dental implant is fixed in such a way that the surfaces of the implant are free and stay intact. In particular, the container comprises an implant with a conditioned surface improving the coating with a patient's own material before insertion. The objective is solved by the subject of the claims and as further described herein. One aim of the inventive container and a dental implant with surface conditioning (doting) is that sterilization, transport, and coating of a dental implant can be performed in one system. The herein provided container comprising a dental implant, enables contacting of a patient's own cellular material with the surface of t