US-12622815-B2 - Mold for manufacturing skin attachable thin film and method for manufacturing skin attachable thin film by using same

US12622815B2US 12622815 B2US12622815 B2US 12622815B2US-12622815-B2

Abstract

Provided is a mold for manufacturing a skin attachable thin film, the mold including: a cast part having a ‘U’ shape to accommodate a mixed solution in an inner space, and including a lower surface part and a side part, and an inner space accommodating the mixed solution; and at least one protruding pillar protruding from at least a partial region of the lower surface part.

Inventors

Jun-Ho Jeong
Sohee JEON
Soon-Hyoung Hwang

Assignees

KOREA INSTITUTE OF MACHINERY & MATERIALS

Dates

Publication Date: 20260512
Application Date: 20211229
Priority Date: 20210721

Claims (16)

1 . A mold for manufacturing a skin attachable thin film, the mold comprising: a cast part accommodating a mixed solution in an inner space; and a plurality of protruding pillars in the cast part, the skin attachable thin film being manufactured on an upper surface of the protruding pillars; and a pillar accommodation protrusion protruding in a closed curve from an outer peripheral surface of the upper surface of the protruding pillars and having a polygonal or circular shape, wherein the cast part includes a lower surface part forming a bottom and a side part vertically protruding from an outer peripheral surface of the lower surface part, and the plurality of protruding pillars protrude from the lower surface part.
2 . The mold of claim 1 , wherein a pillar microstructure is on the upper surface of the protruding pillars.
3 . The mold of claim 1 , wherein the upper surface of the protruding pillars is a curved surface.
4 . The mold of claim 1 , wherein the cast part includes a plurality of holes capable of being opened and closed that are disposed between the protruding pillars.
5 . A manufacturing method of a skin attachable thin film using the mold for manufacturing a skin attachable thin film according to claim 1 , the method comprising: accommodating the mixed solution in an inner space by supplying the mixed solution to the cast part; drying the mixed solution accommodated in the inner space for the mixed solution supplied to the cast part to be changed into the skin attachable thin film; and separating the skin attachable thin film that is formed as the drying the mixed solution is performed from the cast part.
6 . The method of claim 5 , wherein the skin attachable thin film that is acquired in the separating the thin film is formed on an upper surface of a protruding pillar.
7 . The method of claim 5 , wherein the skin attachable thin film that is acquired in the separating the thin film is formed in an inner region surrounded by an accommodation protrusion.
8 . The method of claim 5 , further comprising: between the drying the mixed solution and the separating the thin film, selectively coating a functional material on the skin attachable thin film; and drying and solidifying the coated functional material.
9 . The method of claim 8 , wherein the coating the functional material further includes coating an aqueous solution to gather the functional material coated on the skin attachable thin film.
10 . The method of claim 9 , wherein the coating the aqueous solution further includes additionally supplying the mixed solution.
11 . The method of claim 8 , wherein in the separating the thin film, the skin attachable thin film is separated from the cast part by bringing an adhesive film including an adhesive into contact with the cast part.
12 . The method of claim 11 , wherein the adhesive film separates the plurality of skin attachable thin films by being manufactured to have a length substantially the same as a length of the cast part or have a length shorter than the length of the cast part and greater than a distance between the protruding pillars.
13 . The method of claim 11 , wherein the adhesive film separates the skin attachable thin film by being manufactured to have a length substantially the same as a length of the protruding pillar or have a length greater than the length of the protruding pillar and shorter than a distance between the protruding pillars.
14 . A mold for manufacturing a skin attachable thin film, the mold comprising: a cast part accommodating a mixed solution in an inner space; and a plurality of protruding pillars in the cast part, the skin attachable thin film being manufactured on an upper surface of the protruding pillars; and a lower surface accommodation protrusion having a polygonal or circular shape and protruding in a closed curve from a region of the lower surface part without the protruding pillars, wherein the cast part includes a lower surface part forming a bottom and a side part vertically protruding from an outer peripheral surface of the lower surface part, and the plurality of protruding pillars protrude from the lower surface part.
15 . The mold of claim 14 , wherein a lower surface microstructure is formed on a surface of an inner region surrounded by the lower surface accommodation protrusion in the region of the lower surface part without the protruding pillars.
16 . A mold for manufacturing a skin attachable thin film, the mold comprising: a cast part accommodating a mixed solution in an inner space; and a plurality of protruding pillars in the cast part, the skin attachable thin film being manufactured on an upper surface of the protruding pillars, wherein the cast part includes a lower surface part forming a bottom and a side part vertically protruding from an outer peripheral surface of the lower surface part, the plurality of protruding pillars protrude from the lower surface part, and the cast part includes a plurality of separators disposed between the protruding pillars.

Description

TECHNICAL FIELD The present disclosure relates to a technique for manufacturing a thin film, and particularly, to a mold for manufacturing a skin attachable thin film and a manufacturing method of a skin attachable thin film using the same. BACKGROUND ART In generally, most medicines may be orally administered. However, a certain medicine, especially a protein or peptide medicine, may not be effectively adsorbed into a human body by this method due to its intense degradation in the gastrointestinal tract, its poor absorption from an intestinal cell membrane, and/or an interruption of its first-pass by the liver. Another medicine administration technique may be parenteral injection using a standard syringe or a catheter. Needle injection may cause a needle phobia, a substantial pain, and a local damage to the skin in many patients. Retrieval of a body fluid, such as blood, for a diagnostic purpose may raise a similar concern. In addition, the needle injection may not be ideal for a regular medicine delivery or a regular diagnosis. Still another medicine delivery technique may use a transdermal delivery method, which usually relies on spread of the medicine across the skin. This method may not be widely used due to poor skin permeability of many medicines. The stratum corneum, which is an outermost layer of the skin, may represent a main barrier to penetration of the transdermal medicine. When the medicine once reaches a dermal depth (i.e., below the epithelium), the medicine may quickly spread to a deeper tissue layer and other parts of the body through blood circulation. In an attempt to improve a rate of protein medicine delivery through the skin, chemical enhancers, iontophoresis, electroporation, ultrasound, and thermal devices have been used to supplement the medicine delivery. In order to perform the medicine delivery through the skin, it may be necessary to manufacture a thin film capable of being attached to the skin. In general, the thin film may be manufactured in a process of injecting a solution having a low concentration (of 30% or less) into a mold, then drying the same in air, vacuum, blowing, hot air, or the like, separating the thin film from the mold, and cutting the same into a plurality of thin films having a size required for a product. However, when manufacturing the thin film by using this manufacturing process, the dried thin film in a region of the mold where its bottom and wall surface meet each other may be distorted due to shrinkage or separated from a mold surface. Accordingly, it may be difficult to perform post-process on the thin film separated from the mold surface, and it may be very difficult to form a precise and flat thin film. DISCLOSURE Technical Problem The present disclosure attempts to provide a mold for manufacturing a plurality of precise and flat thin films, and a manufacturing method of a skin attachable thin film using the same. The present disclosure also attempts to provide a mold for manufacturing a plurality of thin films without any additional post-process after a drying process, and a manufacturing method of a skin attachable thin film using the same. The present disclosure also attempts to provide a mold for manufacturing thin films having different thicknesses through a single process, and a manufacturing method of a skin attachable thin film using the same. The present disclosure also attempts to provide a mold allowing reuse of a solution used in the manufacturing of a skin attachable thin film, and a manufacturing method of a skin attachable thin film using the same. Technical Solution According to an embodiment, provided is a mold for manufacturing a skin attachable thin film, the mold including: a cast part accommodating a mixed solution in an inner space; and a protruding pillar formed in the cast part, the skin attachable thin film being manufactured on an upper surface of the protruding pillar, wherein the cast part includes a lower surface part forming a bottom and a side part vertically protruding from an outer peripheral surface of the lower surface part, and a plurality of protruding pillars protrude from the lower surface part. Here, a first microstructure may be on the upper surface of the protruding pillar. In addition, the upper surface of the protruding pillar may be a curved surface. Meanwhile, The mold may further include a first accommodation protrusion protruding from an outer peripheral surface of the upper surface of the protruding pillar. In addition, the mold may further include a second accommodation protrusion having a polygonal or circular shape and protruding in a closed curve from a region of the lower surface part without the protruding pillar. In addition, a second microstructure may be formed on a surface of an inner region surrounded by the second accommodation protrusion in the region of the lower surface part without the protruding pillar. Meanwhile, the cast part may include a plurality of separators disposed between