US-12622942-B2 - Method for treating coronavirus infectious disease and complicated severe coma, ultra-low blood oxygen, moribund disease thereof

Abstract

The present invention relates to a method for treating a coronavirus infectious disease and a complication thereof, including: administering a Chinese medicine composition to a subject in need thereof; wherein, the Chinese medicine composition is an extract of a first mixture including Ephedra sinica, Armeniacae Semen amarum, Glycyrrhizae radix et rhizoma, Gypsum fibrosum, Descurainiea semen, stephaniae Tetrandrae radix, Scutellariae radix, Poria, rhizoma alismatis, Polyporus umbellatus, Atractylodis rhizoma, Asteris radix et rhizoma, Tussilago farfara, Pinelliae rhizoma , and Rhei radix et rhizoma.

Inventors

• Hsuan-Ching TSENG
• Da-Tong Ju
• Chi-Tun TANG
• Tung-Han Tsai
• Tsai-Wang HUANG
• Ming-Chin KU
• Tzu-Li LIN
• Kun-Cheng Lin
• Chen-Yu Lee

Assignees

• Hsuan-Ching TSENG

Dates

Publication Date

20260512

Application Date

20221004

Claims (7)

1. 1 . A method for treating a coronavirus infectious disease and a complication thereof, comprising: administering a Chinese medicine composition to a subject in need thereof, wherein, the Chinese medicine composition is an extract of a first mixture consisting of 2-4 parts by weight of Ephedra sinica, 7-9 parts by weight of Armeniacae semen amarum, 4-6 parts by weight of Glycyrrhizae radix et rhizoma, 7-9 parts by weight of Gypsum fibrosum, 7-9 parts by weight of Descurainiea semen, 4-6 parts by weight of Stephaniae tetrandrae radix, 7-9 parts by weight of Scutellariae radix, 7-9 parts by weight of Poria, 3-5 parts by weight of Rhizoma alismatis, 3-5 parts by weight of Polyporus umbellatus, 3-5 parts by weight of Atractylodis rhizoma, 3-7 parts by weight of Asteris radix et rhizoma, 3-7 parts by weight of Tussilago farfara, 3-5 parts by weight of Pinelliae rhizoma , 2-4 parts by weight of Rhei radix et rhizome, 0-3 parts by weight of Ginseng radix et rhizome and 0-3 parts by weight of Anredera cordifolia.
2. 2 . The method of claim 1 , wherein the Chinese medicine composition is prepared by the following steps: providing the first mixture; mixing the first mixture with water to form a second mixture; heating the second mixture to obtain a crude extract; and filtering the crude extract and keeping a filtrate to obtain the Chinese medicine composition.
3. 3 . The method of claim 1 , wherein the first mixture consists of 2-4 parts by weight of Ephedra sinica, 7-9 parts by weight of Armeniacae semen amarum, 4-6 parts by weight of Glycyrrhizae radix et rhizoma, 7-9 parts by weight of Gypsum fibrosum, 7-9 parts by weight of Descurainiea semen, 4-6 parts by weight of Stephaniae tetrandrae radix, 7-9 parts by weight of Scutellariae radix, 7-9 parts by weight of Poria, 3-5 parts by weight of Rhizoma alismatis, 3-5 parts by weight of Polyporus umbellatus, 3-5 parts by weight of Atractylodis rhizoma, 5-7 parts by weight of Asteris radix et rhizoma, 5-7 parts by weight of Tussilago farfara, 3-5 parts by weight of Pinelliae rhizoma, 2-4 parts by weight of Rhei radix et rhizoma, 1-3 parts by weight of Ginseng radix et rhizoma and 1-3 parts by weight of Anredera cordifolia.
4. 4 . The method of claim 1 , wherein the coronavirus is severe acute respiratory syndrome coronavirus 2 (SARS-COV-2).
5. 5 . The method of claim 1 , wherein the Chinese medicine composition is administered via oral administration or injection.
6. 6 . The method of claim 1 , wherein the Chinese medicine composition further comprises pharmaceutically acceptable carrier, stabilizer, diluent, dispersant, suspending agents, thickening agent, excipient, or a combination thereof.
7. 7 . The method of claim 1 , wherein the complication comprises low blood oxygen, wherein the low blood oxygen is defined as a blood oxygen below 80 mmHg.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method for treating a coronavirus infectious disease and a complication thereof, and, more particularly, to a method for treating acute respiratory syndrome coronavirus 2 (SARS-CoV-2). 2. Description of Related Art Traditional Chinese medicine has gradually attracted attention in recent years due to the potential of Chinese medicine for coronavirus infectious diseases and complications thereof. The principle of applying Chinese medicine is based on the practice of traditional Chinese medicine theory. The novel coronavirus broke out in Wuhan at the end of 2019, and then spread to countries around the world. In 2020, the International Committee on Taxonomy of Viruses officially named it severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the World Health Organization (WHO) also officially named the disease caused by such virus as COVID-19. Most of the COVID-19 patients are asymptomatic or mildly symptomatic, but some patients will rapidly develop into severe illness after infection. Such disease is life-threatening and has a high mortality rate, so it is extremely difficult to be treated clinically. However, there is no specific medicine for COVED-19 patients nowadays, and supportive care is applied to the patient with the help of the medical personal mainly. The supportive care refers to a treatment for controlling and alleviating the complications or drug side effects with the purpose of preventing the patient from excessive pain until the patient produces antibody and recovers. Therefore, it is desirable to provide a new therapeutic drug or treat lent method for the patient infected with the coronavirus at present, to alleviate a coronavirus infectious disease and a complication thereof. SUMMARY OF THE INVENTION A first aspect of the present invention relates to a Chinese medicine composition for treating a cornavirus infectious disease and a complication thereof, wherein the Chinese medicine composition comprises an extract of a first mixture comprising Ephedra sinica, Armeniacae Semen amarum, Glycyrrhizae radix et rhizoma, Gypsum fibrosum, Descurainiea semen, stephaniae Tetrandrae radix, Scutellariae radix, Poria, rhizoma alismatis, Polyporus umbellatus, Atractylodis rhizoma, Asteris radix et rhizoma, Tussilago farfara, Pinelliae rhizoma, and Rhei radix et rhizoma. The first mixture of the first mixture of the present invention nay comprise 2-4 parts by weight of Ephedra sinica, 7-9 parts by weight of Armeniacae Semen amarum, 4-6 parts by weight of Glycyrrhizae radix et rhizoma, 7-9 parts by weight of Gypsum fibrosum, 7-9 parts by weight of Descurainiea semen, 4-6 parts by weight of stephaniae Tetrandrae radix, 7-9 parts by weight of Scutellariae radix, 7-9 parts by weight of Poria, 3-5 parts by weight of rhizoma alismatis, 3-5 parts by weight of Polyporus umbellatus, 3-5 parts by weight of Atractylodis rhizoma, 3-7 parts by weight of Asteris radix et rhizoma, 3-7 parts by weight of Tussilago farfara, 3-5 parts by weight of Pinelliae rhizoma, and 2-4 parts by weight of Rhei radix et rhizoma. Said first mixture of the present invention may further comprise at least one ingredient selected from—the group consisting of Ginseng radix et rhizoma and Anredera cordifolia. In one embodiment of the present invention, the first mixture may further comprise at least one ingredient selected from the group consisting of 1-3 parts by weight of Ginseng radix et rhizoma and 1-3 parts by weight of Anredera cordifolia. Said mixture may further comprise Ginseng radix et rhizoma and Anredera cordifolia. In one embodiment of the present invention, the first mixture may further comprise 1-3 parts by weight of Ginseng radix et rhizoma and 1-3 parts by weight of Anredera cordifolia. A second aspect of the present invention relates to a Chinese medicine composition for treating a coronavirus infectious disease and a complication thereof, wherein the Chinese medicine composition comprises an extract of a first mixture comprising Ephedra sinica, Armeniacae Semen amarum, Scutellariae radix, Poria, Atractylodis rhizoma, Asteris radix et rhizoma, Tussilago farfara, Pinelliae rhizoma, Ginseng radix et rhizoma, Anredera cordifolia, Salviae miltiorrhizae radix et rhizoma, radix glycyrrhizae, Aucklandiae radix, Amomi fructus, Schisandra chinensis, Citri reticulatae pericarpium, Ginkgo semen, Dioscoreae rhizoma, Pimenta officinalis, Zingiberis rhizoma, and Aconiti lateralis radix praeparata. The first mixture of the second aspect of the present invention gay comprise 2-4 parts by weight of 2-4 parts by weight of Ephedra sinica, 3-5 parts by weight of Armeniacae Semen amarum, 7-9 parts by weight of Scutellariae radix, 2-4 parts by weight of Poria, 2-4 parts by weight of Atractylodis rhizoma, 3-5 parts by weight of Asteris radix et rhizoma, 3-5 parts by weight of Tussilago farfara, 3-5 parts by weight of Pinelliae rhizoma, 2-4 parts by wei