US-12622943-B2 - Composition for relieving woman menopausal symptom comprising a mixed extract of hop and citrus peel and method for treating or alleviating menopausal symptom using the same

US12622943B2US 12622943 B2US12622943 B2US 12622943B2US-12622943-B2

Abstract

The present disclosure relates to a composition for treating or alleviating female menopausal symptoms, which contains a mixed extract of hop and citrus peel as an active ingredient, and a method for treating or alleviating menopausal symptoms. The composition of the present disclosure has superior effect of alleviating or treating female menopausal symptoms, particularly cardiovascular disease and/or osteoporosis.

Inventors

Dong-Jun Park
Eun-Mi SUN
Hong-Gu Lee
Ho-Song Cho

Assignees

LG HOUSEHOLD & HEALTH CARE LTD.

Dates

Publication Date: 20260512
Application Date: 20230404
Priority Date: 20220404

Claims (10)

1 . A method for treating or alleviating female menopausal symptoms, comprising a step of administering an effective amount of a mixed extract of hop, citrus peel, and Pueraria flower to an individual in need of treatment or alleviation of female menopausal symptoms, wherein the mixed extract comprises hop, citrus peel and Pueraria flower are at a weight ratio of 1:0.1-10:0.1-10.
2 . The method for treating or alleviating female menopausal symptoms according to claim 1 , wherein the method comprises a step of administering a composition comprising the mixed extract, and the composition comprises 5-20 wt % of a hop extract and 5- 20 wt % of a citrus peel extract based on the total weight of the composition.
3 . The method for treating or alleviating female menopausal symptoms according to claim 1 , wherein the female menopausal symptoms comprise at least one of menopausal cardiovascular disease or osteoporosis.
4 . The method for treating or alleviating female menopausal symptoms according to claim 1 , wherein the mixed extract comprises 8-prenylnaringenin and hesperidin, and the mixed extract comprises 0.1-8 mg/g of 8-prenylnaringenin and 80-170 mg/g of hesperidin.
5 . The method for treating or alleviating female menopausal symptoms according to claim 1 , wherein the method provides estrogen receptor beta activity, osteoblast differentiation-promoting effect, bone component production-promoting effect, cholesterol synthase activity-inhibiting effect, and nitric oxide production-promoting effect.
6 . The method for treating or alleviating female menopausal symptoms according to claim 1 , wherein the mixed extract comprises hop, citrus peel and Pueraria flower at a weight ratio of 1:0.15-8:0.15-8.
7 . The method for treating or alleviating female menopausal symptoms according to claim 1 , wherein the mixed extract comprises hop, citrus peel and Pueraria flower at a weight ratio of 1:0.5-5:0.5-5.
8 . The method for treating or alleviating female menopausal symptoms according to claim 1 , wherein the mixed extract comprises hop, citrus peel and Pueraria flower at a weight ratio of 1:1-3:1-3.
9 . The method for treating or alleviating female menopausal symptoms according to claim 1 , the mixed extract of hop, citrus peel and Pueraria thomsonii flower is contained in an amount of 0.01-65 wt % based on the total composition.
10 . The method for treating or alleviating female menopausal symptoms according to claim 1 , the mixed extract of hop, citrus peel and Pueraria thomsonii flower is contained in an amount of 10-52 wt % based on the total composition.

Description

TECHNICAL FIELD The present disclosure relates to a composition for alleviating female menopausal disorder and a method for treating or alleviating menopausal disorder using the same. More particularly, it relates to a composition comprising a mixed plant extract capable of alleviating various symptoms of female menopausal disorder, a use of the extract, and a method for treating or alleviating female menopausal disorder using the mixed extract. BACKGROUND ART Menopause is the time in women's lives when the reproductive function declines and ceases gradually. As women enter menopause, changes occur throughout the body including the vascular system, musculoskeletal system, genitourinary system and cranial nerves due to the imbalance and decrease in secretion of female hormones. That is to say, vasomotor symptoms and psychological symptoms are accompanied such as hot flushes, night sweats, sleep disorder, fatigue, depression, anxiety, inability to concentrate, memory disorder, dyspareunia due to urogenital atrophy, frequent urination, loss of skin elasticity due to collagen reduction, and breast sagging. It is also accompanied by various diseases such as dementia. Although menopausal symptoms differ from person to person, it has been reported that the quality of life of women worsens as more menopausal symptoms are experienced and as they are more severe and last longer. In addition, the menopausal symptoms are highly likely to develop into chronic diseases with physical aging. In addition, during menopause, symptoms such as cold sweat, fatigue, nervousness, headache, sleep disorder (insomnia or early awakening), anxiety, apathy, dispiritedness, depression, muscle and joint pain, dizziness, etc. may appear. Among these symptoms, depression and anxiety are the most frequent symptoms experienced by modern people and have the greatest impact on the quality of life. Therefore, it is important to manage depression and anxiety well during menopause. In addition, it has been reported that the effect of estrogen on blood lipids, that is, problems with cholesterol content control, causes thromboembolism and hypertension and, in serious cases, can cause arteriosclerotic cardiovascular diseases. During menopause, estrogen level is decreased, which is one of the factors that increase the risk of osteoporosis. Estrogen plays a role in promoting bone-forming cells and maintaining bone density. However, when estrogen level is decreased due to menopause, the secretion of nerve growth factor for maintaining bone tissue is decreased and, as a result, the strength of bone tissue is decreased and the risk of osteoporosis is increased. In addition, during menopause, the decreased in bone density can be accelerated further due to factors such as body weight increase, reduced physical activity, etc. As the quality of life is improved gradually, the desire to manage the symptoms occurring during menopause and to spend a healthy menopausal period is increasing. Since hormone preparations widely used in existing medicines have immediate effects but have many side effects, interest in natural materials that can alleviate the female menopausal symptoms is increasing, and the need to study new physiological functions of various biological species is increasing gradually. In this regard, various preceding researches have been conducted, but researches on natural materials for alleviating female menopausal symptoms that contain ingredients that can be safely consumed by human as active ingredients and can improve the quality of life during menopause are still insufficient. For treatment of menopausal symptoms, hormone therapy, drug therapy, exercise therapy and diet therapy can be applied. But, long-term use of female hormone therapy, which is widely used medically, can increase the risk of breast cancer, etc. and may increase the risk of uterine cancer, thrombotic vascular disease, gallbladder disease and hypertension. Therefore, in recent years, many researches have been conducted on phytoestrogens, which are reported to have functions similar to those of estrogen, to replace estrogen therapy and other drug therapies. In many cases, the ingredients known to be effective in alleviating menopausal symptoms are effective for only one of the menopausal symptoms (e.g., hot flushes, osteoporosis, etc.). However, since more than one menopausal symptoms occur at the same time, it is important that complex effects are exhibited on various menopausal symptoms. 8-Prenylnaringenin, known as a functional ingredient of hop, is used in hormone replacement therapy for menopausal disorders. However, it is known that increased uterine weight and abnormal hormonal changes are observed when it is administered to animals at high doses. Accordingly, excessive use of hop may cause side effects. Therefore, various researches are being conducted on methods that can be safely administered with few side effects while being effective for treating or alleviating men