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US-12622967-B2 - Molecules, formulations, and methods for nutritional support of athletes, patients, and others

US12622967B2US 12622967 B2US12622967 B2US 12622967B2US-12622967-B2

Abstract

The present invention relates to nutritional formulations for increasing sports and other physical performance and that have beneficial effects on health and wellness for various populations. The invention includes molecular compounds as disclosed. A preferred embodiment is a molecule type based on a glycerol backbone, with three glycerol functional groups B 1 , B 2 , B 3 , wherein one or more of the B groups may correspond to one of the functional energy groups A 1 , A 2 or A 3 , as disclosed. The invention includes nutritional formulations, some based on the inventive molecular compounds. The invention also includes method of using, administering, and implementing the above, including computer implemented and computer assisted methods.

Inventors

  • George A. Brooks
  • Michael A. Horning
  • Iñigo San Millán

Assignees

  • TODAY, INC.

Dates

Publication Date
20260512
Application Date
20240519

Claims (6)

  1. 1 . A molecule, as shown: wherein functional group B 1 comprises beta hydroxybutyrate, functional group B 2 comprises beta hydroxybutyrate and functional group B 3 comprises lactate or pyruvate.
  2. 2 . An aqueous formulation comprising: a molecule, as shown: wherein functional group B 1 comprises beta hydroxybutyrate, functional group B 2 comprises beta hydroxybutyrate and functional group B 3 comprises lactate or pyruvate.
  3. 3 . The formulation of claim 2 further comprising an aqueous nutritional formulation for humans or mammals or both.
  4. 4 . The formulation of claim 2 wherein the formulation is suitable for administration by one or more of the following: intravenously, enterally, orally.
  5. 5 . The formulation of claim 2 wherein the formulation is hypertonic.
  6. 6 . The formulation of claim 2 wherein the formulation is isotonic.

Description

APPLICATION PRIORITY DATA The current patent application is a continuation of Ser. No. 18/096,794 by inventors Brooks, Homing, and San Millán, which claims priority claims priority to U.S. provisional patent application 63/300,563 filed Jan. 18, 2022, by inventors Brooks and Homing. FIELD OF THE INVENTION The present disclosure generally relates to the field of nutritional supplementation. Molecules, formulations, and methods for nutritional support of endurance athletes and others are disclosed. BACKGROUND OF THE INVENTION The present invention relates to formulations for preparing oral dietary supplements including sports drinks, useful for increasing sports and other physical performances and with beneficial effects on health and wellness. Traditional sports drinks haven't changed much in formulation since introduction of Gatorade (trademarked name) in 1965. Since then the main ingredients in commercially available sports drinks have been electrolytes and simple sugars such as glucose, fructose, and sucrose. In recent years some companies have added other components such as maltodextrin, branched chain amino acids, and amino acids such as glutamine. Drawbacks of current sports drink formulations stem from the fact that many who manufacture them lack an appreciation of fundamentals of exercise physiology and metabolism. For example, the drinks contain more or less hexoses that utilize the same set of intestinal solute transporters. Hence, adding more of the same class of solutes only saturates pathways of solute absorption limiting the mass of solute and water transport giving rise to gastrointestinal (GI) distress. In terms of solute transport, current sports drink formulations do not recognize that some classes of intestinal transporters are faster than others for moving solute from GI tract into blood. As well, sports drinks in the prior art do not contemplate that some transporters are symporters that facilitate solute transport with a cation, typically sodium ion (Na+), and to a lesser extent potassium ion (K+). Co-transport provides the opportunity to move into blood from intestine two efficacious moieties necessary for supporting needs of energy-depleted and dehydrated athletes. As well, current sports drinks contain either cations Na+ or K+ without regard to the cation levels in blood of healthy individuals that also contains lesser, but important amounts of calcium (Ca++), magnesium (Mg++), as well as anion counter ions including hydrogen phosphate (HPO42−) and dihydrogen phosphate (H2PO4−), and chloride (Cl−). And finally, perhaps the greatest deficiency of those who manufacture current sports drinks is that they lack understanding of fuel energy substrates that the body, working muscles, heart, liver, kidneys, brain and sweat glands need and that optimal exercise performance requires integrative functioning of those diverse organ systems. Hence, current sports drinks are not optimal for supplying the metabolites needed to rapidly supply energy, electrolytes, and water for optimum performance. Furthermore, until recently, the recommendations for dietary carbohydrate consumption during endurance activities called for about 30-60 g/h. In this field of endeavor as well in nutrition science in general, carbohydrates are organic compounds containing the atoms carbon (C), hydrogen (H), and oxygen (O) with hydrogen and oxygen in the same ratio as water (2:1). However, in 2008 and based on substrate utilization analyses with competitive athletes, we realized that in contrast to 60 g/hr, consumption of 80-120 g/h would be more effective. We started using that approach with world-class athletes including athletes at the highest level of professional sports. That novel approach 13 years ago was not free of challenges as it was not easy to meet those carbohydrate requirements of 80-120 g/h. A major obstacle was that it wasn't easy to find sports drinks with high carbohydrate concentration and free of gastrointestinal issues for that high amount of carbohydrate. The field of health and wellness is one of the largest markets in the world. There is a constant quest to find new products that can improve fitness, health, and well being. However, the majority of the products in the market lack scientific evidence to support claims of efficacy and eventually fade away because the products do not benefit the individual. SUMMARY OF THE INVENTION The invention includes, but is not limited to the following, with variations. The invention includes, in a preferred embodiment, a nutritional formulation for humans and mammals including: a first molecule including gluconeogenic (GNG) precursors or monocarboxylate compounds (MCC). The abbreviation GNG is used herein to mean gluconeogenesis or gluconeogenic, and fractional gluconeogenesis is sometimes referred to as fGNG. The formulation also includes a second molecule type, based on a glycerol backbone, as illustrated in FIG. 23, in a preferred embodiment. FIG. 23 illustrat