US-12622998-B2 - Liquid dressing

US12622998B2US 12622998 B2US12622998 B2US 12622998B2US-12622998-B2

Abstract

A liquid dressing includes a solvent and a film-forming polymer that is dissolved in the solvent and that is made by a process including: providing an alkoxy group-containing silicone resin which is obtained by subjecting an orthosilicate compound and an acidic aqueous solution to a hydrolysis and polymerization reaction; providing an isocyanate group-containing prepolymer which is obtained by reacting a diisocyanate compound with a hydrophilic polyether diol; and subjecting the alkoxy group-containing silicone resin and the isocyanate group-containing prepolymer to a polymerization reaction so as to obtain the film-forming polymer.

Inventors

Szu-Hsien Chen
Ya-Wen KU
Yen-Hsuan Liu

Assignees

TRONJEN MEDICAL TECHNOLOGY INC.

Dates

Publication Date: 20260512
Application Date: 20220310
Priority Date: 20210720

Claims (9)

1 . A liquid dressing, comprising: a solvent; and a film-forming polymer dissolved in said solvent and made by a process including: providing an alkoxy group-containing silicone resin which has a partially cross-linked network and which is obtained by subjecting an orthosilicate compound and an acidic aqueous solution to a hydrolysis and polymerization reaction; providing an isocyanate group-containing prepolymer which is obtained by reacting a diisocyanate compound with a hydrophilic polyether diol; and subjecting said alkoxy group-containing silicone resin and said isocyanate group-containing prepolymer to a polymerization reaction so as to obtain said film-forming polymer, wherein said solvent is hexamethyldisilazane.
2 . The liquid dressing as claimed in claim 1 , wherein said orthosilicate compound is selected from the group consisting of tetraethyl orthosilicate, tetramethyl orthosilicate, and a combination thereof.
3 . The liquid dressing as claimed in claim 1 , wherein said diisocyanate compound is selected from the group consisting of hexamethylene diisocyanate, dicyclohexylmethane-4,4′-diisocyanate, isophorone diisocyanate, and combinations thereof.
4 . The liquid dressing as claimed in claim 1 , wherein said hydrophilic polyether diol is polyethylene glycol.
5 . The liquid dressing as claimed in claim 4 , wherein said polyethylene glycol has a weight average molecular weight ranging from 400 g/mol to 2000 g/mol.
6 . The liquid dressing as claimed in claim 1 , wherein a molar ratio of said orthosilicate compound to water in said acidic aqueous solution ranges from 1:3,5 to 1:3.9.
7 . The liquid dressing as claimed in claim 1 , wherein a molar ratio of said diisocyanate compound to said hydrophilic polyether diol ranges from 1.1:1 to 1.5:1.
8 . The liquid dressing as claimed in claim 1 , wherein said alkoxy group-containing silicone resin has a weight average molecular weight ranging from 10000 g/mol to 30000 g/mol.
9 . The liquid dressing as claimed in claim 1 , wherein said film-forming polymer is free from an aromatic ring structure.

Description

CROSS-REFERENCE TO RELATED APPLICATION This application claims priority of Taiwanese Invention Patent Application No. 110126615, filed on Jul. 20, 2021. FIELD The present disclosure relates to a liquid dressing, and more particularly to a liquid dressing containing a polysiloxane-polyurethane copolymer. BACKGROUND In order to facilitate recovery of an open wound such as skin incision or abrasion, great care of the open wound (for example, reducing its exposure to external stimuli (e.g., water or dirt) would be required. Moreover, the breathability, ease of use and comfort of touch regarding a dressing material used for protecting the open wound should also be taken into account. CN 109200333 A discloses a skin protective liquid composition that can be sprayed onto the skin to form a non-irritant skin protection film. The skin protective liquid composition is made from a linear polymer compound that has a polyphenylhydroxysiloxane structure, and that is dissolved in a solvent. However, after being sprayed, the skin protective liquid composition would easily clog the nozzle of the spray bottle, causing inconvenience in use of such skin protective liquid composition. If the spray bottle containing the skin protection liquid composition is filled with a pressurized gas, there might be a risk of danger during transportation. SUMMARY Therefore, the present disclosure provides a liquid dressing which can alleviate at least one of the drawbacks of the prior art. The liquid dressing includes a solvent and a film-forming polymer dissolved in the solvent. The film-forming polymer is made by a process including: providing an alkoxy group-containing silicone resin which is obtained by subjecting an orthosilicate compound and an acidic aqueous solution to a hydrolysis and polymerization reaction;providing an isocyanate group-containing prepolymer which is obtained by reacting a diisocyanate compound with a hydrophilic polyether diol; andsubjecting the alkoxy group-containing silicone resin and the isocyanate group-containing prepolymer to a polymerization reaction so as to obtain the film-forming polymer. BRIEF DESCRIPTION OF THE DRAWINGS Other features and advantages of the present disclosure will become apparent in the following detailed description of the embodiments with reference to the accompanying drawings, of which: FIG. 1 shows scanning electron microscopy images of a first polypropylene tape applied to the skin (A) before spraying the liquid dressing of Example 1, and a second polypropylene tape applied to the skin (B) after spraying the liquid dressing in Example 1, infra; and FIG. 2 shows photographs of pieces of toilet paper with water droplets dispensed thereon after being respectively sprayed with (A) the liquid dressing of Example 1, (B) the liquid dressing of Comparative Example 1, and (C) the liquid dressing of Comparative Example 2. DETAILED DESCRIPTION It is to be understood that, if any prior art publication is referred to herein, such reference does not constitute an admission that the publication forms a part of the common general knowledge in the art, in Taiwan or any other country. For the purpose of this specification, it will be clearly understood that the word “comprising” means “including but not limited to”, and that the word “comprises” has a corresponding meaning. Unless otherwise defined, all technical and scientific terms used herein have the meaning commonly understood by a person skilled in the art to which this disclosure belongs. One skilled in the art will recognize many methods and materials similar or equivalent to those described herein, which could be used in the practice of this disclosure. Indeed, this disclosure is in no way limited to the methods and materials described. The present disclosure provides a liquid dressing which includes a solvent and a film-forming polymer dissolved in the solvent. The film-forming polymer is made by a process including: providing an alkoxy group-containing silicone resin which is obtained by subjecting an orthosilicate compound and an acidic aqueous solution to a hydrolysis and polymerization reaction;providing an isocyanate group-containing prepolymer which is obtained by reacting a diisocyanate compound with a hydrophilic polyether diol; andsubjecting the alkoxy group-containing silicone resin and the isocyanate group-containing prepolymer to a polymerization reaction so as to obtain the film-forming polymer. In certain embodiments, the orthosilicate compound is selected from the group consisting of tetraethyl orthosilicate (TEOS), tetramethyl orthosilicate (TMOS), and a combination thereof. In certain embodiments, the solvent is hexamethyldisilazane (HMDS). In certain embodiments, the diisocyanate compound is selected from the group consisting of hexamethylene diisocyanate (HDI), dicyclohexylmethane-4,4′-diisocyanate (H12MDI), isophorone diisocyanate (IPDI), and combinations thereof. In certain embodiments, the hydrophilic polyether diol i