US-12623022-B1 - Medicament delivery device

US12623022B1US 12623022 B1US12623022 B1US 12623022B1US-12623022-B1

Abstract

A medicament delivery device for injecting medicament is described. The device has a body having a proximal end and a distal end, a needle for injecting medicament, an actuation member which is movable relative to the body from a first position to a second position for dispensing medicament from the needle, a lock ring which is rotatable relative to the body from a pre-use position, in which movement of the actuation member from the first position to the second position is prevented, to a use position in which movement of the actuation member from the first position to the second position is permitted and a cap which is removably attached to the medicament delivery device. The cap has a portion which is configured to prevent rotation of the lock ring from the pre-use position to the use position when the cap is attached to the medicament delivery device.

Inventors

Alexander Hee-Hanson
Thomas LEVER
Michael Parrott
Robert Wilson
HAIMING WU

Assignees

GENZYME CORPORATION

Dates

Publication Date: 20260512
Application Date: 20250226

Claims (15)

1 . A medicament delivery device for injecting medicament, wherein the medicament delivery device comprises: a body having a proximal end and a distal end defining a longitudinal axis; a needle; an actuation member movable relative to the body from a first position to a second position for dispensing the medicament via the needle; a lock ring rotatable relative to the body from a pre-use position in which movement of the actuation member from the first position to the second position is prevented, to a use position in which a movement of the actuation member from the first position to the second position is permitted; an axially-extending component rotationally constrained relative to the lock ring, wherein one of the axially-extending component and the lock ring comprises a first protrusion and the other of the axially-extending component and the lock ring comprises a first recess, and wherein the first protrusion is configured to be received in the first recess to constrain rotation of the axially-extending component relative to the lock ring, the axially-extending component being independently rotatable relative to the lock ring prior to engagement of the first protrusion and the first recess; and a cap removably attached to the medicament delivery device, wherein the cap comprises a proximally-extending portion configured to engage the axially-extending component to prevent rotation of the lock ring from the pre-use position to the use position when the cap is attached to the medicament delivery device, wherein one of the axially-extending component and the proximally-extending portion comprises a second protrusion and the other of the axially-extending component and the proximally-extending portion comprises a second recess, and wherein the second recess is a radially-extending recess extending towards the longitudinal axis and the second protrusion is a radially-extending protrusion extending towards the longitudinal axis and configured to be received in the radially-extending recess to rotationally constrain the proximally-extending portion relative to the axially-extending component when the cap is attached to the medicament delivery device, and wherein the engagement between the second protrusion and the second recess is released upon removal of the cap.
2 . The medicament delivery device according to claim 1 , wherein the cap is removably attached to the body.
3 . The medicament delivery device according to claim 1 , wherein the proximally-extending portion of the cap is rotationally constrained relative to the body when the cap is attached to the medicament delivery device.
4 . The medicament delivery device according to claim 3 , wherein one of the proximally-extending portion of the cap and the body comprises a third protrusion and the other of the proximally-extending portion of the cap and the body comprises a third recess, and wherein the cap and the body are configured such that when the cap is attached to the medicament delivery device, the third protrusion is received in the third recess to constrain rotation of the portion of the cap relative to the body.
5 . The medicament delivery device according to claim 1 , wherein the proximally-extending portion of the cap engages the axially-extending component when the lock ring is in the pre-use position.
6 . The medicament delivery device according to claim 1 , wherein the axially-extending component and the proximally-extending portion of the cap are located radially inwards from the body.
7 . The medicament delivery device according to claim 1 , wherein the axially-extending component and the lock ring are separate components.
8 . The medicament delivery device according to claim 1 , wherein the proximally-extending portion of the cap is configured to prevent rotation of the lock ring relative to the body when the cap is attached to the medicament delivery device.
9 . The medicament delivery device according to claim 1 , wherein the actuation member is configured to be rotated with the lock ring when the lock ring rotates from the pre-use position to the use position.
10 . The medicament delivery device according to claim 1 , wherein the actuation member comprises a button configured to be pressed to move the actuation member from the first position to the second position.
11 . The medicament delivery device according to claim 1 , wherein the medicament delivery device comprises a dispensing mechanism configured to dispense medicament via the needle, and wherein the actuation member is configured to release the dispensing mechanism when the actuation member is in the second position.
12 . The medicament delivery device according to claim 1 , further comprising a container containing the medicament.
13 . The medicament delivery device of claim 1 , wherein the axially-extending component is a cylindrical sleeve.
14 . A method of preparing a medicament delivery device for use prior to dispensing medicament from the medicament delivery device, the method comprising: removing a cap from the medicament delivery device, wherein the cap comprises a proximally-extending portion configured to prevent rotation of a lock ring of the medicament delivery device from a pre-use position to a use position; and rotating the lock ring from the pre-use position to the use position, wherein the medicament delivery device comprises: a body having a proximal end and a distal end defining a longitudinal axis; a needle; an actuation member movable relative to the body from a first position to a second position for dispensing the medicament via the needle; the lock ring rotatable relative to the body from the pre-use position in which movement of the actuation member from the first position to the second position is prevented, to the use position in which a movement of the actuation member from the first position to the second position is permitted; an axially-extending component rotationally constrained relative to the lock ring, wherein one of the axially-extending component and the lock ring comprises a first protrusion and the other of the axially-extending component and the lock ring comprises a first recess, and wherein the first protrusion is configured to be received in the first recess to constrain rotation of the axially-extending component relative to the lock ring, the axially-extending component being independently rotatable relative to the lock ring prior to engagement of the first protrusion and the first recess; and the cap removably attached to the medicament delivery device, wherein the cap comprises a proximally-extending portion configured to engage the axially-extending component to prevent rotation of the lock ring from the pre-use position to the use position when the cap is attached to the medicament delivery device, wherein one of the axially-extending component and the proximally-extending portion comprises a second protrusion and the other of the axially-extending component and the proximally-extending portion comprises a second recess, and wherein the second recess is a radially-extending recess extending towards the longitudinal axis and the second protrusion is a radially-extending protrusion extending towards the longitudinal axis and configured to be received in the radially-extending recess to rotationally constrain the proximally-extending portion relative to the axially-extending component when the cap is attached to the medicament delivery device, and wherein the engagement between the second protrusion and the second recess is released upon removal of the cap.
15 . A method of using a medicament delivery device, the method comprising: removing a cap from the medicament delivery device, wherein the cap comprises a portion configured to prevent rotation of a lock ring of the medicament delivery device from a pre-use position to a use position; rotating the lock ring from the pre-use position to the use position; and moving an actuation member from a first position to a second position for dispensing medicament from the medicament delivery device, wherein the medicament delivery device comprises: a body having a proximal end and a distal end defining a longitudinal axis; a needle; an actuation member movable relative to the body from a first position to a second position for dispensing the medicament via the needle; the lock ring rotatable relative to the body from the pre-use position in which movement of the actuation member from the first position to the second position is prevented, to the use position in which a movement of the actuation member from the first position to the second position is permitted; an axially-extending component rotationally constrained relative to the lock ring, wherein one of the axially-extending component and the lock ring comprises a first protrusion and the other of the axially-extending component and the lock ring comprises a first recess, and wherein the first protrusion is configured to be received in the first recess to constrain rotation of the axially-extending component relative to the lock ring, the axially-extending component being independently rotatable relative to the lock ring prior to engagement of the first protrusion and the first recess; and the cap removably attached to the medicament delivery device, wherein the cap comprises a proximally-extending portion configured to engage the axially-extending component to prevent rotation of the lock ring from the pre-use position to the use position when the cap is attached to the medicament delivery device, wherein one of the axially-extending component and the proximally-extending portion comprises a second protrusion and the other of the axially-extending component and the proximally-extending portion comprises a second recess, and wherein the second recess is a radially-extending recess extending towards the longitudinal axis and the second protrusion is a radially-extending protrusion extending towards the longitudinal axis and configured to be received in the radially-extending recess to rotationally constrain the proximally-extending portion relative to the axially-extending component when the cap is attached to the medicament delivery device, and wherein the engagement between the second protrusion and the second recess is released upon removal of the cap.

Description

TECHNICAL FIELD The present disclosure relates to a medicament delivery device, a method of preparing a medicament delivery device for use and a method of using a medicament delivery device. BACKGROUND Medicament delivery devices, such as auto-injectors, are known in the art for dispensing medicament to an injection site of a patient. In some cases, the needle actuator can be depressed accidentally, for example, before the device is ready and/or in position for use. Depressing the needle actuator accidentally can cause a dose of medicament to be unintentionally dispensed. This can lead to a waste of medicament. SUMMARY According to a first aspect of the present disclosure, there is provided a medicament delivery device for injecting medicament, wherein the medicament delivery device comprises a body having a proximal end and a distal end; a needle for injecting medicament; an actuation member which is movable relative to the body from a first position to a second position for dispensing medicament from the needle; a lock ring which is rotatable relative to the body from a pre-use position, in which movement of the actuation member from the first position to the second position is prevented, to a use position in which movement of the actuation member from the first position to the second position is permitted; and a cap which is removably attached to the medicament delivery device, wherein the cap comprises a portion which is configured to prevent rotation of the lock ring from the pre-use position to the use position when the cap is attached to the medicament delivery device. The cap may be removably attached to the body. The portion may be rotationally constrained relative to the body when the cap is attached to the medicament delivery device. One of the portion and the body may comprise a protrusion and the other of the portion and the body may comprise a recess, and wherein when the cap is attached to the medicament delivery device then the protrusion is received in the recess to constrain rotation of the portion relative to the body. The medicament delivery device may further comprise an axially-extending component which is rotationally constrained relative to the lock ring, and wherein the portion is configured to engage the axially-extending component to prevent rotation of the lock ring to the use position when the cap is attached to the medicament delivery device. The portion may engage the axially-extending component when the lock ring is in the pre-use position. One of the axially-extending component and the portion may comprise a protrusion and the other of the axially-extending component and the portion may comprise a recess, and wherein the protrusion is received in the recess to constrain rotation of the axially-extending component relative to the portion. The axially-extending component and the portion may be located radially outwards from the body. The axially-extending component and the portion may be located radially inwards from the body. The lock ring may comprise the axially-extending component. The axially-extending component may be a separate component to the lock ring. One of the axially-extending component and the lock ring may comprise a protrusion and the other of the axially-extending component and the lock ring may comprise a recess, and wherein the protrusion is received in the recess to constrain rotation of the axially-extending component relative to the lock ring. The portion may be configured to prevent rotation the lock ring relative to the body when the cap is attached to the medicament delivery device. The actuation member may be configured to be rotated with the lock ring when the lock ring rotates from the pre-use position to the use position. The medicament delivery device may comprise a stop which engages the actuation member to prevent the actuation member from moving from the first position to the second position when the lock ring is in the pre-use position. The actuation member may comprise a button which is configured to be pressed to move the actuation member from the first position to the second position. The medicament delivery device may comprise a dispensing mechanism configured to dispense medicament from the needle, and wherein the actuation member is configured to release the dispensing mechanism when the actuation member is in the second position. The medicament delivery device may further comprise a container containing the medicament. According to another aspect of the present disclosure, there is provided a method of preparing a medicament delivery device for use prior to dispensing medicament from the device, the method comprising removing a cap from the medicament delivery device, wherein the cap comprises a portion configured to prevent rotation of a lock ring of the medicament delivery device from a pre-use position to a use position; and rotating the lock ring from the pre-use position to the use position. According to another aspect of the pres