US-12623064-B2 - Stereotactic guidance device

US12623064B2US 12623064 B2US12623064 B2US 12623064B2US-12623064-B2

Abstract

Disclosed is a stereotactic guidance device comprising a guide handle coupled inside the driving part, and configured to accommodate a guide tube unit, adjusting the guide tube unit to be positioned toward a target point, and guiding the guide tube unit so that the guide tube unit is provided inside the driving part; a probe accommodating part provided at the guide handle and accommodating a navigation probe; a tube connecting part connected to the guide handle, provided as at least a pair of members to be assembled and disassembled, having one end portion inserted into the guide handle and the other end portion mounted at an upper portion of the guide handle, and guiding the guide tube unit so that the guide tube unit is inserted into and mounted in the driving part; and a guide wire provided in the guide handle and the guide tube unit.

Inventors

Boo Rak LEE
Ji Won SEONG
Duk Lyul Na
Seung Hoon Lee
Jeong Min Lee
Woo Ram Jung
Kap Soo KIM
Nak Soon PARK

Assignees

MYO SEONG
SAMSUNG LIFE PUBLIC WELFARE FOUNDATION

Dates

Publication Date: 20260512
Application Date: 20201221
Priority Date: 20200224

Claims (8)

1 . A stereotactic guidance device that rotates a driving part of a drug injection device in order to find a target point in a patient's skull and is detachably provided so that a guide tube unit can be provided in the driving part, comprising: a guide handle that is coupled inside the driving part, and is configured to accommodate the guide tube unit, adjust the guide tube unit to be positioned toward the target point, and guide the guide tube unit so that the guide tube unit is provided inside the driving part; a probe accommodating part that is provided at the guide handle and accommodates a navigation probe that finds a trajectory for the target point; a tube connecting part that is connected to the guide handle, is provided as at least a pair of members to be assembled and disassembled, has one end portion inserted into the guide handle and the other end portion mounted at an upper portion of the guide handle, and guides the guide tube unit so that the guide tube unit is inserted into and mounted in the driving part; and a guide wire that is provided in the guide handle and the guide tube unit, and guides and adjusts a direction toward the target point.
2 . The stereotactic guidance device according to claim 1 , wherein the guide handle has a coupling hole that is formed in a hollow shape so that at least one of the probe accommodating part, the navigation probe, the guide wire, and the guide tube unit is inserted therein, and includes: an insertion part that is inserted in the driving part; a coupling part that is extended from the insertion part and is coupled to the driving part; a handling part that is formed to be tapered in the coupling part and is located outside the driving part to perform handling during a procedure; and an insertion guide part that is formed to be rounded inside the handling part, is located at an end portion of the coupling hole, and guides insertion of the tube connecting part in a direction of the coupling hole when the tube connecting part is inserted therein.
3 . The stereotactic guidance device according to claim 1 , wherein a probe insertion hole is formed inside the probe accommodating part, and the probe accommodating part includes a central axis aligning part that has at least one side that is inserted into the driving part and is flatly blocked, and is configured to find the nearest target point by aligning the central axis without a direction error when the driving part rotates.
4 . The stereotactic guidance device according to claim 1 , wherein the tube connecting part is formed with a guide hole at the central portion thereof, in which at least one of the guide wire and the guide tube is inserted and directed to the target point, and serves as a double guide together with the guide handle, and includes: a first connecting part that is mounted on the guide handle; and a second connecting part that is extended from the first connecting part, has a smaller diameter, and is inserted into the guide handle.
5 . The stereotactic guidance device according to claim 1 , wherein the guide wire is formed in a round shape at a tip thereof capable of being inserted into brain parenchyma.
6 . The stereotactic guidance device according to claim 1 , further comprising: a wire handling part is formed with a hole in which the guide wire is inserted at a central portion thereof.
7 . The stereotactic guidance device according to claim 6 , wherein the wire handling part includes: a fixing part that is fixedly accommodated in the guide handle; a grip part that is connected to the fixing part and is formed with a gripping groove to be gripped in handling the guide wire on at least one side thereof; a mounting part that is connected to the grip part and is mounted on the guide handle; and a fastening accommodation part that is formed with a fastening groove on at least one side thereof to enable fixed coupling between the guide wire and the wire handling part.
8 . The stereotactic guidance device according to claim 7 , wherein the wire handling part further includes a fastening part that is provided to be fit-coupled in the fastening accommodation part, and the fastening part includes: a head part having a concave and convex pattern formed on the outside thereof to prevent slipping in rotational handling of the fastening part; a body part that is fastened to the fastening accommodation part, and provides the fixed coupling between the guide wire and the wire handling part; and a neck part that is positioned between the head part and the body part, and is configured to provide height adjustment to facilitate fastening and separation of the head part and the body part.

Description

FIELD OF INVENTION The present invention relates to a stereotactic guidance device, and particularly to, a stereotactic guidance device with improved precision, accuracy, and ease of use for guiding a drug injection device for repeatedly administering a drug so that the drug injection device is mounted at a target point within the skull of a patient. BACKGROUND OF THE INVENTION Recently, diseases that lower quality of life such as diabetic, psychiatric, and cancer require continuous and repeated drug administration in order to control blood sugar rise or reduce pain. However, in the case of patients with gastrointestinal cancer such as gastric cancer, the traditional oral administration method may have difficulties in drug administration itself, and may cause side effects due to systemic circulation of drugs. On the other hand, since a method of directly administering drugs to the spinal cord, which is a nerve route, exhibits drug effects 300 times greater than oral administration and 100 times greater than intravenous administration, hospitalization for administration of drugs such as insulin and painkillers is unnecessary, and thus, it is possible to reduce the number of days of stay for pain treatment, thereby reducing social and economic costs. Accordingly, a drug injection device for repeated drug administration is designed to be mounted on a part of the body such as the patient's abdomen and brain in order to repeatedly administer fluids such as insulin, dementia treatment agents, and subcutaneously administered drugs for brain diseases. In this regard, in the case of patients with brain tumors, brain diseases, and dementia, in drug administration, it is necessary to effectively deliver a drug into the brain for remedial results. Accordingly, in preferentially considering the drug delivery efficiency, the best method is to directly administer the drug into the brain parenchyma after incising a surgical site to form a bur hole and mounting the drug injection device in the bur hole. On the other hand, the biggest barrier to direct administration using the drug injection device is a route of administration. In the case of a drug that targets the brain, there is a difficulty in that the drug should pass through the blood-brain barrier (BBB). Further, in the case of repeated administration, it is not easy to implant the drug injection device at the same target location again, and in a case where it is implanted at a slightly different point, side effects such as post-operative inflammation may occur, which increases the cost of surgery and causes side effects. Accordingly, the drug injection device needs to be mounted to enable repeated administration. Here, in making the drug reach the target point using the drug injection device, the drug injection device should be connected and mounted while avoiding the surrounding structures that control important brain functions. In addition, a stereotactic guidance device is needed for guiding direction change of a guide tube of the drug injection device through a bur hole formed by making a hole in the skull and to accurately aim the guide tube toward a lesion that is the target point. In the related art, so-called “frameless stereotaxy” that is mounted in or around a bur hole to provide surgical guidance to a neurosurgeon and assist in planning or performing surgery has been proposed. However, this technique has a complicated structure and takes a lot of time to mount the device. Further, this technique has a limitation in that since the bur hole of the skull has a limited diameter, the size and position of a target region in the brain parenchyma that can be accessed through the bur hole are also limited. That is, since the drug injection device is mounted so that a central axis is set from a position where the drug injection device is initially mounted on the skull to the target point, in a case where the target point is moved or the drug needs to be injected at a different target point, there is a limitation in that the skull should be punctured at another position. SUMMARY OF THE INVENTION To solve the above-mentioned problems, an object of the present invention is to provide a stereotactic guidance device capable of guiding a guide tube of a drug injection device to be positioned toward a target point in the brain parenchyma of a patient with brain-related diseases and diseases, precisely and accurately positioning the guide tube close to the target point, and enabling direction change with respect to a central axis. Further, another object of the present invention is to provide a stereotactic guidance device capable of being easily handled by an operator in mounting and removal. According to an aspect of the present invention, there is provided a stereotactic guidance device that rotates a driving part of a drug injection device in order to find a target point in a patient's skull and is detachably provided so that a guide tube unit can be provided in the dri