US-12623231-B2 - Magnetic substance separation device

US12623231B2US 12623231 B2US12623231 B2US 12623231B2US-12623231-B2

Abstract

A magnetic substance separation device is configured for attracting magnetic substances in a sample within a sample container. The magnetic substance separation device includes a casing and at least one magnetic component assembly. The casing has at least one accommodation compartment. The at least one magnetic component assembly is disposed in the at least one accommodation compartment, and the at least one magnetic component assembly includes at least four cubic magnetic components. In addition, the at least four cubic magnetic components are linearly arranged with different magnetization directions, allowing magnetic field lines of the at least one magnetic component assembly to concentrate on one side, such that the at least one magnetic component assembly forms at least one strong magnetic surface on the casing. The at least one strong magnetic surface is configured to attract the magnetic substances in the sample within the sample container.

Inventors

Nien-Jen Chou
Nien-Tzu CHOU
LI-AN WU
Su feng CHIOU

Assignees

INNOCELL TECHNOLOGY CO., LTD.

Dates

Publication Date: 20260512
Application Date: 20241227

Claims (8)

1 . A magnetic substance separation device, configured for attracting magnetic substances in a sample within a sample container, and the magnetic substance separation device comprising: a casing, comprising a main housing, a plurality of partitions and a base, the plurality of partitions are arranged in the main housing to form a plurality of parallel elongated grooves on the main housing, the base is secured to the main housing for forming a plurality of accommodation compartments together with the main housing and the plurality of partitions, and the base having a plurality of openings respectively connected to the plurality of accommodation compartments; a holder, disposed on an upper end of the casing and including a through hole, wherein the holder is configured to secure the sample container onto the at least one strong magnetic surface of the casing, and the through hole is configured for a tube part of the sample container to be disposed through, allowing the tube part to correspond to the at least one strong magnetic surface, and a periphery of the through hole is configured to support an opening flange part of the sample container; an inclined support pivotally coupled to an end of the casing, wherein the inclined support is configured to selectively raise a horizontal height of the end of the casing to be greater than or equal to a horizontal height of other parts of the casing; and at least one magnetic component assembly, comprising at least four cubic magnetic components, the at least four cubic magnetic components are inserted into the accommodation compartments through the plurality of openings, wherein the at least four cubic magnetic components in one of the plurality of accommodation compartments are arranged in an offset configuration relative to the at least four cubic magnetic components in another of the plurality of accommodation compartments; wherein the at least four cubic magnetic components are linearly arranged with different magnetization directions, allowing magnetic field lines of the at least one magnetic component assembly to concentrate on one side, such that the at least one magnetic component assembly forms at least one strong magnetic surface on the casing, and the at least one strong magnetic surface is configured to attract the magnetic substances in the sample within the sample container.
2 . The magnetic substance separation device according to claim 1 , wherein the at least four cubic magnetic components are arranged in Halbach array.
3 . The magnetic substance separation device according to claim 1 , wherein the at least one magnetic component assembly further forms a weak magnetic surface on the casing, and the weak magnetic surface and the at least one strong magnetic surface are located on opposite sides of the casing.
4 . The magnetic substance separation device according to claim 1 , wherein the at least one magnetic component assembly comprises a plurality of magnetic component assemblies, and the plurality of magnetic component assemblies are respectively disposed in the plurality of accommodation compartments.
5 . The magnetic substance separation device according to claim 4 , wherein each two adjacent cubic magnetic components within the same accommodation compartment are in physical contact with each other.
6 . The magnetic substance separation device according to claim 4 , wherein the casing has a plurality of partitions, the plurality of partitions are respectively disposed between two adjacent accommodation compartments, a thickness of each of the plurality of partitions ranges from 1.0 mm to 10.0 mm, and a thickness of the casing at the at least one strong magnetic surface ranges from 1.0 mm to 10.0 mm.
7 . The magnetic substance separation device according to claim 1 , wherein the at least one magnetic component assembly is in physical contact with an inner peripheral surface of at least one accommodation compartment.
8 . The magnetic substance separation device according to claim 1 , wherein a side length of each cubic magnetic component ranges from 1 mm to 15 mm.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS This application claims priority to U.S. Provisional Application Ser. No. 63/615,650, filed on Dec. 28, 2023, the entirety of which is incorporated by reference herein. TECHNICAL FIELD This disclosure relates to a magnetic substance separation device. BACKGROUND Conventional magnetic substances separation experiments often face multiple challenges. First of all, the magnetic force of magnetic substances from different manufacturers varies significantly, as well as the characteristics of biological samples (such as encapsulation phenomena) can affect the magnetic interaction, resulting in reduced separation efficiency. Secondly, the diversity of experimental containers makes it difficult to optimize magnetic interactions. Additionally, the relationship between magnetic force and distance also affects the separation effect. Conventional magnetic separation devices often struggle to balance efficiency, convenience, automation, biosafety and biocompatibility, limiting the advancement of magnetic separation experiments. Therefore, how to provide a magnetic separation device that meets the requirements for efficiency, convenience, automation, biosafety and biocompatibility, while allowing flexible selections of suitable container shapes, surface materials and surface treatment methods according to the characteristics of different samples, remains a pressing challenge in this field for researchers. SUMMARY The present disclosure provides a magnetic substance separation device that enhances the efficiency of magnetic interactions by optimizing the arrangement of magnets, utilizing a strong magnetic force design, and adapting to different container shapes, thereby offering a more comprehensive and reliable solution for magnetic substance separation experiments. One embodiment of the disclosure provides a magnetic substance separation device configured for attracting magnetic substances in a sample within a sample container. The magnetic substance separation device includes a casing and at least one magnetic component assembly. The casing has at least one accommodation compartment. The at least one magnetic component assembly is disposed in the at least one accommodation compartment, and the at least one magnetic component assembly includes at least four cubic magnetic components. In addition, the at least four cubic magnetic components are linearly arranged with different magnetization directions, allowing magnetic field lines of the at least one magnetic component assembly to concentrate on one side, such that the at least one magnetic component assembly forms at least one strong magnetic surface on the casing. The at least one strong magnetic surface is configured to attract the magnetic substances in the sample within the sample container. According to the magnetic substance separation device as disclosed in the embodiment of the disclosure, a strong magnetic surface can be formed on the casing by arranging the cubic magnetic components in a specific manner, thereby providing stronger magnetic force per unit area with fewer magnetic components. Furthermore, the magnetic substance separation device can be adjusted to adapt to different container shapes, thereby improving the efficiency of magnetic interactions while meeting the requirements for efficiency, convenience, automation, biosafety and biocompatibility simultaneously. BRIEF DESCRIPTION OF THE DRAWINGS The present disclosure will become better understood from the detailed description given herein below and the accompanying drawings which are given by way of illustration only and thus are not intending to limit the present disclosure and wherein: FIG. 1 is a perspective view of a magnetic substance separation device in accordance with the first embodiment of the disclosure; FIG. 2 is an exploded view of the magnetic substance separation device as shown in FIG. 1; FIG. 3 illustrates a schematic diagram of the magnetic force distribution formed by four cubic magnetic components linearly arranged with different magnetization directions; FIG. 4 illustrates a schematic diagram of the magnetic force distribution formed by five cubic magnetic components linearly arranged with different magnetization directions; FIG. 5 is a perspective view of a magnetic substance separation device in accordance with the second embodiment of the disclosure; FIG. 6 is a side view of the magnetic substance separation device as shown in FIG. 5 and a sample container in a horizontal placement; FIG. 7 is a side view of the magnetic substance separation device as shown in FIG. 5 and the sample container in an inclined placement; FIG. 8 is a perspective view of a magnetic substance separation device in accordance with the third embodiment of the disclosure; FIG. 9 is a perspective view of a magnetic substance separation device in accordance with the fourth embodiment of the disclosure; FIG. 10 is a perspective view of a magnetic substance separation