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US-12624233-B2 - DNA based biodegradable resin composition

US12624233B2US 12624233 B2US12624233 B2US 12624233B2US-12624233-B2

Abstract

The present disclosure relates to a DNA-based biodegradable resin composition. The DNA resin composition prepared by combining DNA as a polymer and Bipyridine-based compound as a flocculant has excellent physical properties and biodegradability, so it can be used as a bioplastic material.

Inventors

  • Jong Bum Lee
  • Hyunsu Jeon

Assignees

  • UNIVERSITY OF SEOUL INDUSTRY COOPERATION FOUNDATION

Dates

Publication Date
20260512
Application Date
20221201
Priority Date
20211201

Claims (3)

  1. 1 . DNA resin composition comprising: DNA as a polymer; and a bipyridine-based compound as a flocculant, wherein the DNA and the bipyridine-based compound are combined, and wherein the bipyridine-based compound is represented by the following Chemical Formula (1): in Chemical Formula 1, R 1 and R 2 are straight chain or branched chain alkyl groups of C2 to C8, respectively.
  2. 2 . The DNA resin composition of claim 1 , wherein the molar ratio of the base pair of the DNA and the bipyridine-based compound is 1˜3:1.5˜3, and the number of moles of DNA is based on base pairs.
  3. 3 . Bioink compositions for 3D printing, comprising DNA and bipyridine-based compounds, and wherein the bipyridine-based compound is represented by the following Chemical Formula (1): in Chemical Formula 1, R 1 and R 2 are straight chain or branched chain alkyl groups of C2 to C8, respectively.

Description

TECHNICAL FIELD The present disclosure claims the benefit of the filing date of Korean Patent Application No. 10-2021-0169886 submitted to the Korean Patent Office on Dec. 1, 2021, and all of its contents are included in the present disclosure. The present disclosure relates to a DNA-based biodegradable resin composition. The DNA resin composition prepared by combining DNA as a polymer and bipyridine-based compounds as flocculants has excellent physical properties and biodegradability, so it can be used as a bioplastic material. BACKGROUND Plastics have excellent physical properties and processability and a low price, so they are used in various fields. However, conventional plastics do not decompose in the natural environment, and only 9% of all plastics are recycled, which is a problem for environmental pollution. To solve this problem, biodegradable bioplastics are required to replace petroleum-based non-degradable plastics. Currently, commercialized biodegradable plastics include starch-based plastics, polylactic acid (PLA), polyhydroxyalkanoate (PHA), etc. However, starch-based plastics have a problem of environmental pollution and a decrease in food production due to the increase in the cultivation of corn and sugarcane, which are their raw materials, PLA has a problem of low biodegradability in the marine environment, and PHA is produced by microorganisms, so there is a problem that the production is not sufficient, and the price is high. (Assignment Information) The present disclosure was derived by carrying out the task of task number 2021-RMD-S04 of the Science and Technology Employment Promotion Agency, and the research task name Development of bioplastic materials for biodegradable polymer-based R&D (2021 Apr. 1˜2023 Dec. 31)′ of the research project name ‘Research Materials Development Diffusion Support Project’. (Patent Document 1) Korea Public Publication No. 10-2010-0002564 (2010 Jan. 12) SUMMARY The present disclosure provides a DNA resin composition that raw materials can be obtained inexpensively with excellent physical properties and biodegradability. According to embodiment of the present disclosure provides DNA as a polymer; and a DNA resin composition including a bipyridine-based compound as a flocculant, in which the DNA and the bipyridine-based compound are combined. The average molecular weight of the DNA is not particularly limited, for example, 1000 to 2 million, 5000 to 2 million, 10,000 to 2 million, 100,000 to 2 million, 500,000 to 2 million, 1 million to 2 million, 1 million to 1.5 million, or about 1.3 million. The average base pairs of the DNA are not particularly limited, for example, 100 to 3000 bp, 500 to 3000 bp, 1000 to 3000 bp, 100 to 2500 bp, 500 to 2500 bp, 1000 to 2500 bp, or about 2000 bp. The bipyridine-based compound can bind (intercalate) to DNA, and when mixed with DNA and heated above the melting temperature (Tm) of DNA, DNA can be aggregated to form a resin composition in the form of a hydrogel. By separating and drying it, the resin composition of the present disclosure can be obtained. According to one embodiment, the bipyridine-based compound may be represented by the following Chemical Formula 1. In Chemical Formula 1, R1 and R 2 may be straight or branched chain alkyl groups of C 2 to C 10, C 5 to C 9, or C 6 to C 8, respectively. If the carbon number of the substituent is less than or equal to the range, the alkyl group length may be short and aggregation may not occur smoothly, and if the carbon number of the substituent is greater than the range, the length of the alkyl group may be excessively long and the acceptance degree is low, and it may be difficult to react with DNA. The bipyridine-based compound may be N,N′-alkyl-4,4′-bipyridine-based compound or viologen. The N,N′-alkyl-4,4′-bipyridine-based compound or viologen is, for example, dimethylviologen (N, N′-dimethyl-4,4′-bipyridinium dichloride), diethyl biologen (N,N′-diethyl-4,4′-bipyridinium dichloride), dipropyl biologen (N,N′-dipropyl-4,4′-bipyridinium dichloride), dibutyl biogen (N,N′-dibutyl-4,4′-bipyridinium dichloride), dipentyl biologen (N,N′-dipentyl-4,4′-bipyridinium dichloride), dihexyl biogen (N,N′-dihexyl-4,4′-bipyridinium dichloride), diheptyl biogen (N,N′-diheptyl-4,4′-bipyridinium dichloride, DHV), or dibenzyl biogen (N,N′-dibenzyl-4,4′-bipyridinium dichloride, DBV). As the DNA resin composition is dried, the moisture content may be 10% or less, 5% by weight or less, 3% by weight or less, 2% by weight or less, or 1% by weight or less. The drying of the DNA resin composition results in a moisture content of 0.1 to 5% by weight, 0.1 to 4% by weight, 0.1 to 3% by weight, 0.2 to 5% by weight, 0.2 to 4% by weight, 0.2 to 3% by weight, 0.3 to 5% by weight, 0.3 to 4% by weight, 0.3 to 3% by weight, 0.5 to 5% by weight, 0.5 to 4% by weight, 0.5 to 3% by weight, 0.7 to 5% by weight, It may be 0.7 to 4% by weight, 0.7 to 3% by weight, 1.0 to 5% by weight, 1.0 to 4% by weight, or 1.0 to 3