US-12625118-B2 - Idle-triggered diagnostics for scientific instruments

Abstract

Systems or techniques are provided for facilitating idle-triggered diagnostics for scientific instruments. In various embodiments, a scientific instrument can comprise a mass spectrometer coupled to a chromatograph. In various aspects, the scientific instrument can determine, via a temperature sensor of the chromatograph or via a clock of the mass spectrometer, whether the scientific instrument is in an idle-time period. In various instances, the scientific instrument can, in response to a determination that the scientific instrument is in the idle-time period, apply one or more electronic control signals to the mass spectrometer or to the chromatograph, measure one or more resultant ion spectra via an ion detector of the mass spectrometer, and determine whether the mass spectrometer or the chromatograph is operating correctly based on the one or more resultant ion spectra.

Inventors

• Deven Lee Shinholt

Assignees

• THERMO FINNIGAN LLC

Dates

Publication Date

20260512

Application Date

20230818

Claims (20)

1. 1 . A scientific instrument, comprising: a mass spectrometer coupled to a chromatograph; and a processor that executes computer-executable components stored in a non-transitory computer-readable memory, wherein the computer-executable components comprise: a determination component that determines, via a temperature sensor of the chromatograph or via a clock of the mass spectrometer, whether the scientific instrument is in an idle-time period; and a check component that, in response to a determination that the scientific instrument is in the idle-time period, applies one or more electronic control signals to the mass spectrometer or to the chromatograph, measures one or more resultant ion spectra via an ion detector of the mass spectrometer, and determines whether the mass spectrometer or the chromatograph is operating correctly based on the one or more resultant ion spectra.
2. 2 . The scientific instrument of claim 1 , wherein the applying the one or more electronic control signals activates an ion beam emitter of the mass spectrometer, wherein the applying the one or more electronic control signals is purported to cause an ion focusing lens of the mass spectrometer to shift from a pass state to a block state, wherein the one or more resultant ion spectra indicate a first abundance of a first ion measured for the pass state, wherein the one or more resultant ion spectra indicate a second abundance of the first ion measured for the block state, and wherein the first abundance differing from the second abundance by less than a threshold amount indicates that the ion focusing lens is electrically disconnected.
3. 3 . The scientific instrument of claim 1 , wherein the applying the one or more electronic control signals causes an ion beam emitter of the mass spectrometer to charge an ion focusing lens of the mass spectrometer, wherein the one or more resultant ion spectra indicate a first abundance of a first ion measured prior to such charging, wherein the one or more resultant ion spectra indicate a second abundance of the first ion measured after such charging, and wherein the first abundance differing from the second abundance by more than a threshold amount indicates that the ion focusing lens is contaminated with an ion burn.
4. 4 . The scientific instrument of claim 1 , wherein the applying the one or more electronic control signals deactivates an ion beam emitter of the mass spectrometer, wherein the one or more resultant ion spectra indicate an abundance of a first ion measured after such deactivation, and wherein the abundance being above a threshold indicates that the ion detector suffers from excessive background noise.
5. 5 . The scientific instrument of claim 1 , wherein the applying the one or more electronic control signals opens a fluid valve of the chromatograph, wherein the one or more resultant ion spectra indicate an abundance of a first ion measured after such opening, wherein the first ion corresponds to a fluid of the chromatograph, and wherein the abundance being above a threshold indicates that there is a fluid leak between the chromatograph and the mass spectrometer.
6. 6 . The scientific instrument of claim 1 , wherein the computer-executable components comprise: a result component that, in response to a determination that the mass spectrometer or the chromatograph is not operating correctly, visually renders on an electronic display of the scientific instrument a notification indicating that maintenance is warranted.
7. 7 . The scientific instrument of claim 1 , wherein the computer-executable components comprise: a result component that, in response to a determination that the mass spectrometer or the chromatograph is not operating correctly, visually renders on an electronic display of the scientific instrument a notification indicating that a tuning operation previously performed on the mass spectrometer or on the chromatograph was not successful.
8. 8 . A computer-implemented method, comprising: determining, by a scientific instrument comprising a mass spectrometer coupled to a chromatograph, whether the scientific instrument is in an idle-time period, based on a temperature sensor of the chromatograph or based on a clock of the mass spectrometer; and executing, by the scientific instrument and based at least in part on a determination that the scientific instrument is in the idle-time period, a diagnostic check on the mass spectrometer or on the chromatograph.
9. 9 . The computer-implemented method of claim 8 , wherein the diagnostic check is a lens connection check, a voltage or current readback check, an ion optics charging check, a fluid leak check, a filament control check, a background noise check, an ion fragmentation check, an electrospray stability check, a calibrant solution check, an ion transfer tube check, a polarity switching check or a communication check.
10. 10 . The computer-implemented method of claim 8 , further comprising: executing, by the scientific instrument and in response to the determination that the scientific instrument is in the idle-time period, a tuning operation on the mass spectrometer or on the chromatograph, wherein the diagnostic check is executed in response to completion of the tuning operation.
11. 11 . The computer-implemented method of claim 10 , further comprising: visually rendering, by the scientific instrument, in response to the diagnostic check indicating that the mass spectrometer or the chromatograph has failed to operate within a threshold tolerance, and on an electronic display of the scientific instrument, a notification indicating that the tuning operation was not successful.
12. 12 . The computer-implemented method of claim 8 , further comprising: executing, by the scientific instrument and in response to the determination that the scientific instrument is in the idle-time period, a tuning operation on the mass spectrometer or on the chromatograph, wherein the diagnostic check is executed in response to an anomaly encountered during the tuning operation.
13. 13 . The computer-implemented method of claim 12 , further comprising: visually rendering, by the scientific instrument, in response to the diagnostic check indicating that constituent hardware of the mass spectrometer or of the chromatograph has failed to operate within a threshold tolerance, and on an electronic display of the scientific instrument, a notification indicating that damage to the constituent hardware is responsible for the anomaly.
14. 14 . The computer-implemented method of claim 8 , wherein the diagnostic check is performed in response to the determination that the scientific instrument is in the idle-time period, and further comprising: executing, by the scientific instrument and in response to the diagnostic check indicating that constituent hardware of the mass spectrometer or of the chromatograph has failed to operate within a threshold tolerance, a tuning operation on the constituent hardware.
15. 15 . The computer-implemented method of claim 8 , further comprising: rendering, by the scientific instrument, in response to the diagnostic check indicating that constituent hardware of the mass spectrometer or of the chromatograph has failed to operate within a threshold tolerance, and on an electronic display of the scientific instrument, a notification indicating that maintenance of the constituent hardware is warranted.
16. 16 . A computer program product for facilitating idle-triggered diagnostics for scientific instruments, the computer program product comprising a non-transitory computer-readable memory having program instructions embodied therewith, the program instructions executable by a processor to cause the processor to: measure a temperature of a chromatograph that is coupled to a mass spectrometer; execute, in response to a determination that the temperature indicates an idle-time period of the mass spectrometer, a tuning operation on the mass spectrometer; and verify whether the tuning operation was successful, by executing, during the idle-time period and after the tuning operation, a diagnostic check on the mass spectrometer, wherein the diagnostic check involves measuring an ion spectrum via an ion detector of the mass spectrometer and comparing the ion spectrum to a threshold.
17. 17 . The computer program product of claim 16 , wherein the diagnostic check is a lens connection check or an ion optics charging check.
18. 18 . The computer program product of claim 16 , wherein the chromatograph is a gas chromatograph or a liquid chromatograph.
19. 19 . The computer program product of claim 16 , wherein the program instructions are further executable to cause the processor to: identify, in response to the ion spectrum failing to satisfy the threshold, a maintenance task corresponding to the diagnostic check.
20. 20 . The computer program product of claim 19 , wherein the program instructions are further executable to cause the processor to: schedule performance of the maintenance task.

Description

BACKGROUND Scientific instruments can comprise complex arrangements of actuatable parts, sensors, or consumables. Gradual or sudden degradation of any portion of such complex arrangements can occur throughout the useful lives of scientific instruments, which can be undesirable. SUMMARY The following presents a summary to provide a basic understanding of one or more embodiments. This summary is not intended to identify key or critical elements, or delineate any scope of the particular embodiments or any scope of the claims. Its sole purpose is to present concepts in a simplified form as a prelude to the more detailed description that is presented later. In one or more embodiments described herein, devices, systems, computer-implemented methods, apparatus or computer program products that facilitate idle-triggered diagnostics for scientific instruments are described. According to one or more embodiments, a scientific instrument is provided. The scientific instrument can comprise a mass spectrometer coupled to a chromatograph. The scientific instrument can further comprise a non-transitory computer-readable memory that can store computer-executable components. The scientific instrument can further comprise a processor that can be operably coupled to the non-transitory computer-readable memory and that can execute the computer-executable components stored in the non-transitory computer-readable memory. In various embodiments, the computer-executable components can comprise a determination component that can determine, via a temperature sensor of the chromatograph or via a clock of the mass spectrometer, whether the scientific instrument is in an idle-time period. In various aspects, the computer-executable components can comprise a check component that, in response to a determination that the scientific instrument is in the idle-time period, can apply one or more electronic control signals to the mass spectrometer or to the chromatograph, can measure one or more resultant ion spectra via an ion detector of the mass spectrometer, and can determine whether the mass spectrometer or the chromatograph is operating correctly based on the one or more resultant ion spectra. According to one or more embodiments, a computer-implemented method is provided. In various embodiments, the computer-implemented method can comprise determining, by a scientific instrument comprising a mass spectrometer coupled to a chromatograph, whether the scientific instrument is in an idle-time period, based on a temperature sensor of the chromatograph or based on a clock of the mass spectrometer. In various aspects, the computer-implemented method can comprise executing, by the scientific instrument and based at least in part on a determination that the scientific instrument is in the idle-time period, a diagnostic check on the mass spectrometer or on the chromatograph. According to one or more embodiments, a computer program product for facilitating idle-triggered diagnostics for scientific instruments is provided. In various embodiments, the computer program product can comprise a non-transitory computer-readable memory having program instructions embodied therewith. In various aspects, the program instructions can be executable by a processor to cause the processor to measure a temperature of a chromatograph that is coupled to a mass spectrometer. In various instances, the program instructions can be executable to cause the processor to execute, in response to a determination that the temperature indicates an idle-time period of the mass spectrometer, a tuning operation on the mass spectrometer. In various cases, the program instructions can be executable to cause the processor to verify whether the tuning operation was successful, by executing, during the idle-time period and after the tuning operation, a diagnostic check on the mass spectrometer, wherein the diagnostic check can involve measuring an ion spectrum via an ion detector of the mass spectrometer and comparing the ion spectrum to a threshold. DESCRIPTION OF THE DRAWINGS Various embodiments will be readily understood by the following detailed description in conjunction with the accompanying figures. To facilitate this description, like reference numerals designate like structural elements. Embodiments are illustrated by way of example, not by way of limitation, in the figures. The figures are not necessarily drawn to scale. FIG. 1 illustrates an example, non-limiting block diagram of a scientific instrument module in accordance with various embodiments described herein. FIG. 2 is an example, non-limiting flow diagram of a computer-implemented method in accordance with various embodiments described herein. FIG. 3 illustrates a block diagram of an example, non-limiting scientific instrument that facilitates idle-triggered diagnostics in accordance with one or more embodiments described herein. FIG. 4 illustrates a block diagram of an example, non-limiting scientific instrument inc