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US-20260123651-A1 - SMALL DOG FOOD COMPOSITION

US20260123651A1US 20260123651 A1US20260123651 A1US 20260123651A1US-20260123651-A1

Abstract

The present disclosure provides an animal food composition comprising hydrolyzed proteins, fructooligosaccharides (FOS), maize starch, omega-3 fatty acids, omega-6 fatty acids, and 0.26 g/Mcal or less of zeolite by weight relative to the total dry matter weight of the composition, and its use for preventing and/or treating cutaneous adverse food reaction in small dogs.

Inventors

  • Isabelle LESPONNE
  • Benedicte Garzino
  • Lara FOSSATI
  • Laura FAUVIAU
  • Luis Molina
  • Maxime SAUBLET

Assignees

  • MARS, INCORPORATED

Dates

Publication Date
20260507
Application Date
20231006
Priority Date
20221007

Claims (20)

  1. 1 . A nutritionally complete food composition for a companion animal, wherein said companion animal is in particular a small dog, and wherein said composition includes: from about 30 to about 85 g/Mcal of proteins, said proteins comprising at least 80% of hydrolyzed proteins by weight relative to the total dry matter weight of the proteins, from about 3.5 to about 6 g/Mcal of soluble fibers, from about 45 to about 200 g/Mcal of maize starch, from about 0.1 to about 2.5 g/Mcal of omega-3 fatty acids, from about 4 to about 12 g/Mcal of omega-6 fatty acids, and about 0.26 g/Mcal or less of zeolite.
  2. 2 . The food composition according to claim 1 , wherein said soluble fibers are selected from fructooligosaccharides (FOS).
  3. 3 . The food composition according to claim 1 , comprising about 0.026 g/Mcal or less of zeolite, more particularly about 0.0026 g/Mcal or less of zeolite.
  4. 4 . The food composition according to claim 1 , comprising from about 52 to about 65 g/Mcal of proteins, said proteins comprising at least 80% of hydrolyzed proteins by weight relative to the total dry matter weight of the proteins.
  5. 5 . The food composition according to claim 1 , wherein said proteins comprise at least 85% hydrolyzed proteins by weight relative to the total dry matter weight of the proteins.
  6. 6 . The food composition according to claim 1 , wherein the hydrolyzed proteins comprise feather hydrolysates, in particular poultry feather hydrolysates.
  7. 7 . The food composition according to claim 1 , further comprising from about 26 to about 52 g/Mcal of fat.
  8. 8 . The food composition according to claim 7 , wherein the fat is selected from vegetable fat, animal fat, or mixtures thereof.
  9. 9 . The food composition according to claim 8 , wherein the fat is vegetable fat which originates from soja, copra, coconut, wheat, sunflower, safflower, rapeseed, olive, borage, flaxseed, peanuts, blackcurrant seed, cottonseed, germ, corn germ, algae, or a combination thereof.
  10. 10 . The food composition according to claim 8 , wherein the fat is animal fat selected from fish oil, krill oil, poultry fat, pork fat, beef fat or a combination thereof.
  11. 11 . The food composition according to claim 1 , further comprising insoluble fibers, selected from purified cellulose, lignocellulose, soya, corn, wheat, pea, rice hulls, and combinations thereof.
  12. 12 . The food composition according to claim 1 , wherein the omega-3 fatty acids include docosahexaenoic acid (DHA) and/or eicosapentaenoic acid (EPA).
  13. 13 . The food composition according to claim 1 , wherein the omega-6 fatty acids include linoleic acid.
  14. 14 . The food composition according to claim 1 , further comprising one or more veterinary active ingredients selected from dental health ingredients, urinary safety ingredients, and combinations thereof.
  15. 15 . The food composition according to claim 1 , further comprising one or more additional ingredients selected from colorants, flavors, additives, conservatives, vitamins, amino acids, trace elements, and minerals.
  16. 16 . The food composition according to claim 1 , wherein the food composition is in the form of kibble.
  17. 17 . The food composition according to claim 16 wherein the kibble has a size which does not exceed about 12 mm×12 mm×6 mm.
  18. 18 . A method for manufacturing the nutritionally complete food composition of claim 1 including at least one step of mixing the ingredients together.
  19. 19 . A method for preventing and/or treating cutaneous adverse food reaction in a small dog comprising at least a step of administering the nutritionally complete food composition of claim 1 to said small dog.
  20. 20 . A food composition according to claim 19 , wherein the small dog is a dog which weighs 10 kg or less, in particular is an adult dog which weighs 10 kg or less.

Description

CROSS REFERENCE TO RELATED APPLICATIONS This application claims priority to European Patent Application No. 22200232.1, filed on Oct. 7, 2022, which is incorporated herein by reference in its entirety. FIELD OF THE DISCLOSURE The present disclosure relates to the field of animal food compositions for preventing and/or treating cutaneous adverse food reaction, such as allergic inflammatory skin diseases, while also catering to the specific needs and limitations of small dogs. BACKGROUND OF THE DISCLOSURE Cutaneous adverse food reaction (cAFR) is a non-seasonal dermatitis induced by ingestion of allergens and accounts for nearly one in five pruritic dogs. Currently, diagnosis relies on performing an elimination diet trial followed by a re-challenge. A diet formulated with extensively hydrolyzed protein (consisting of free amino-acids and oligopeptides) and produced with stringent quality control measures has been proven efficacious in the diagnosis and management of cAFR. However, while very efficient in the nutritional management of cAFR, these diets cannot be adapted to all animal populations and as such can present drawbacks or side effects. Dermatological ailments remain a major issue in small animal practice with an estimated 15-30% of the world's dog population affected (Scott et al., Muller & Kirk's Small Animal Dermatology VI. Philadelphia, WB Saunders. 2001, pp: 543-666). Amongst the pruritic cases, nearly 20% of the dogs (Olivry T. and Mueller, R. S., Critically appraised topic on adverse food reactions of companion animals (3): prevalence of cutaneous adverse food reactions in dogs and cats. BMC Vet Res 13, 51 (2016)) have true immune-mediated reactions to antigens present in food and express cutaneous and/or gastrointestinal signs (Mueller R. S. and Olivry T., Critically appraised topic on adverse food reactions of companion animals (6): prevalence of noncutaneous manifestations of adverse food reactions in dogs and cats. BMC Vet Res 14, 341 (2018); and Olivry T, and Mueller, R. S., Critically appraised topic on adverse food reactions of companion animals (7): signalment and cutaneous manifestations of dogs and cats with adverse food reactions. BMC Vet Res 15, 140 (2019)). The recommended diagnostic approach involves an elimination diet trial followed by a challenge with the previous diet (Mueller R. S and Olivry T., Critically appraised topic on adverse food reactions of companion animals (4): can we diagnose adverse food reactions in dogs and cats with in vivo or in vitro tests? BMC Vet Res 13, 275 (2017)). However, it is essential to rule out secondary infections and ectoparasites as well endocrine disorders before pursuing a dietary trial (Olivry T. and Mueller R. S., Critically appraised topic on adverse food reactions of companion animals (9): time to flare of cutaneous signs after a dietary challenge in dogs and cats with food allergies. BMC Vet Res 16, 158 (2020)). It was shown in the past that a diet formulated with an extensively hydrolyzed protein source along with maize starch and produced under rigorous quality control measures is a valuable solution for the diagnosis and management of food allergies in dogs (Lesponne et al., DNA and Protein Analyses to Confirm the Absence of Cross-Contamination and Support the Clinical Reliability of Extensively Hydrolysed Diets for Adverse Food Reaction-Pets. Vet. Sci. 2018; Cadiergues et al., Diagnostic value of home-cooked and an extensively hydrolysed diet (Anallergenic™, Royal Canin, France) in the diagnosis of canine adverse food reaction: a randomized prospective multicenter study in 72 dogs. Vet. Dermatol. 2016; 27 (Suppl.1), 6-121 and Bizikova P. and Olivry T., A Randomized, Double-blinded Crossover Trial Testing the Benefit of Two Hydrolysed Poultry-based Commercial Diets for Dogs with Spontaneous Pruritic Chicken Allergy. Vet. Dermatol. 2016; 27 (4): 289). However, while efficient in treating adverse food reaction, these diets are not specifically adapted to the optimal nutritional management of small dogs, and as such, do not consider all the issues that arise with this particular population of animals such as accommodating smaller jaw size, higher risks of urinary stones, constipation and dental diseases. Thus, there remains a need for treatment options for cutaneous adverse food reactions that have clinical efficacy, but are also specifically adapted to the needs of small dogs. Thus, there remains a need for novel diets designed to improve both immune function and barrier defences that are specifically tailored to the needs of small dogs. SUMMARY A first aspect of the present disclosure relates to a nutritionally complete food composition for a companion animal, wherein said companion animal is in particular a small dog, and wherein said composition includes: from about 30 to about 85 g/Mcal of proteins, said proteins comprising at least 80% of hydrolyzed proteins by weight relative to the total dry matter weight of the proteins,from ab