Search

US-20260123864-A1 - TECHNIQUES AND DEVICES ASSOCIATED WITH BLOOD SAMPLING

US20260123864A1US 20260123864 A1US20260123864 A1US 20260123864A1US-20260123864-A1

Abstract

The present invention generally relates to devices and techniques associated with diagnostics, therapies, and other applications, including skin-associated applications, for example, devices for delivering and/or withdrawing fluid from subjects, e.g., through the skin. In some embodiments, the device includes a system for accessing an extractable medium from and/or through the skin of the subject at an access site, and a pressure regulator supported by a support structure, able to create a pressure differential across the skin at at least a portion of the access site. The device may also include, in some cases, a sensor supported by the support structure for determining at least one condition of the extractable medium from the subject, and optionally a signal generator supported by the support structure for generating a signal relating to the condition of the medium determined by the sensor.

Inventors

  • Douglas A. Levinson
  • Howard Bernstein
  • Donald E. Chickering, III
  • Shawn Davis
  • Ramin Haghgooie
  • Mark Michelman

Assignees

  • YOURBIO HEALTH, INC.

Dates

Publication Date
20260507
Application Date
20250609

Claims (20)

  1. 1 - 26 . (canceled)
  2. 27 . A device for withdrawing blood from the skin and/or from beneath the skin of a subject, the device comprising: a fluid transporter; a vacuum chamber having an internal pressure less than atmospheric pressure before blood is withdrawn into the device; and a storage chamber, separate from the vacuum chamber, for receiving blood withdrawn from the subject through the fluid transporter when a negative pressure is applied to the skin of the subject.
  3. 28 . The device of claim 27 , wherein the fluid transporter comprises one or more microneedles.
  4. 29 . The device of claim 28 , wherein at least some of the microneedles are solid.
  5. 30 . The device of claim 28 , wherein at least some of the microneedles are hollow.
  6. 31 . The device of claim 27 , wherein the subject is human.
  7. 32 . The device of claim 27 , wherein the device is self-contained.
  8. 33 . A device for withdrawing blood from the skin and/or from beneath the skin of a subject, the device comprising: a fluid transporter; a first storage chamber for receiving blood withdrawn from the subject through the fluid transporter, the storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood; and a reaction entity contained within the first storage chamber able to react with an analyte contained within the blood, wherein a product of the reaction entity with the analyte is determinable.
  9. 34 . The device of claim 33 , wherein the product is determinable by an external apparatus able to analyze at least a portion of the device.
  10. 35 . The device of claim 34 , wherein the product of the reaction entity with the analyte is determinable as a change in fluorescence.
  11. 36 . The device of claim 33 , wherein the product of the reaction entity with the analyte is determinable as a change in an electrical property.
  12. 37 . The device of claim 33 , wherein the product of the reaction entity with the analyte is determinable as a change in an optical property.
  13. 38 . The device of claim 33 , wherein the product of the reaction entity with the analyte is determinable as a change in a magnetic property.
  14. 39 . The device of claim 33 , wherein the analyte includes glucose.
  15. 40 . The device of claim 33 , wherein the analyte includes oxygen.
  16. 41 . The device of claim 33 , wherein the analyte is an ion.
  17. 42 . The device of claim 33 , wherein the reaction entity includes an antibody.
  18. 43 . The device of claim 33 , wherein the reaction entity includes a protein.
  19. 44 . The device of claim 33 , wherein the reaction entity includes an enzyme.
  20. 45 . A method for analyzing an extractable medium from a subject, comprising: positioning an analysis device, comprising a pathway, adjacent the skin of the subject and, while the device is adjacent the skin: activating an access component of the device to connect the extractable medium with the pathway of the device; activating a pressure controller of the device to urge the extractable medium into the device via the pathway; exposing the medium to a sensor of the device and determining at least one condition of the extractable medium from the subject; and generating a signal relating to the condition of the medium determined by the sensor.

Description

RELATED APPLICATIONS This application claims the benefit of U.S. Provisional Patent Application Ser. No. 61/163,710, filed Mar. 26, 2009, entitled “Systems and Methods for Creating and Using Suction Blisters or Other Pooled Regions of Fluid within the Skin,” by Levinson, et al.; U.S. Provisional Patent Application Ser. No. 61/156,632, filed Mar. 2, 2009, entitled “Oxygen Sensor,” by Levinson, et al.; U.S. Provisional Patent Application Ser. No. 61/269,436, filed Jun. 24, 2009, entitled “Devices and Techniques associated with Diagnostics, Therapies, and Other Applications, Including Skin-Associated Applications,” by Levinson, et al.; U.S. Provisional Patent Application Ser. No. 61/257,731, filed Nov. 3, 2009, entitled “Devices and Techniques associated with Diagnostics, Therapies, and Other Applications, Including Skin-Associated Applications,” by Bernstein, et al.; and U.S. Provisional Patent Application Ser. No. 61/294,543, filed Jan. 13, 2010, entitled “Blood Sampling Device and Method,” by Levinson, et al. Each of the above is incorporated herein by reference. FIELD OF INVENTION The present invention generally relates to interstitial and other bodily fluids for use in analyzing a condition of a subject or treating a subject. The present invention also relates to systems and methods for delivering and/or withdrawing fluid from subjects, e.g., through the skin. BACKGROUND A variety of techniques and methods exist for sensing and responding to conditions to which a subject is exposed, including sensing of physiological conditions of a mammal and/or a surrounding environment. Other techniques exist for delivering and/or withdrawing a fluid from a mammal, such as blood. While many such techniques are suitable for various purposes, techniques that have one or more features such as added simplicity and flexibility of use would be advantageous. SUMMARY OF THE INVENTION The present invention, in some aspects, generally relates to interstitial and other bodily fluids (e.g., blood) for use in analyzing a condition of a subject or treating a subject. In some cases, the present invention also relates to systems and methods for delivering and/or withdrawing fluid from subjects, e.g., through the skin. The subject matter of the present invention involves, in some cases, interrelated products, alternative solutions to a particular problem, and/or a plurality of different uses of one or more systems and/or articles. The present invention is directed to a device for analysis of an extractable medium from a subject in one aspect. In one set of embodiments, the device includes a support structure, means associated with the support structure for accessing the extractable medium from and/or through the skin of the subject at an access site, and a pressure regulator supported by the support structure, able to create a pressure differential across the skin at at least a portion of the access site. In some cases, the device may also include a sensor supported by the support structure, for determining at least one condition of the extractable medium from the subject, and optionally a signal generator supported by the support structure, for generating a signal relating to the condition of the medium determined by the sensor. In some embodiments, the support structure is constructed and arranged to be positioned proximate the skin of the subject. In another set of embodiments, the device includes a support structure constructed and arranged to be positioned proximate the skin of the subject, a fluid transporter for accessing the extractable medium from and/or through the skin of the subject at an access site, a pressure regulator supported by the support structure, able to create a pressure differential across the skin at at least a portion of the access site, a sensor supported by the support structure for determining at least one condition of the extractable medium from the subject, and a signal generator supported by the support structure for generating a signal relating to the condition of the medium determined by the sensor. The device, according to yet another set of embodiments, includes means for accessing the extractable medium from and/or through the skin of the subject at an access site, a pressure regulator able to create a pressure differential across the skin at at least a portion of the access site, a sensor for determining at least one condition of the extractable medium from the subject, and a signal generator for generating a signal relating to the condition of the medium determined by the sensor. In another set of embodiments, the device includes means for accessing the extractable medium from skin and/or from beneath the skin of the subject at an access site, a pressure differential chamber able to create a pressure differential across the skin in at least a portion of the access site in the absence of a piston pump associated with the chamber, a sensor for determining at least one condition of the extractable m