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US-20260124078-A1 - HYDRATING PATCH

US20260124078A1US 20260124078 A1US20260124078 A1US 20260124078A1US-20260124078-A1

Abstract

The present invention relates to a hydrating patch. The hydrating patch ( 100 ) comprises a biodegradable and biocompatible absorbent inset ( 106 ). The absorbent inset ( 106 ) absorbs and retains a liquid, and discharge an absorbed liquid when pressed. The hydrating patch ( 100 ) also comprises a biocompatible matrix ( 102 ) which supports the absorbent inset ( 106 ). The biocompatible matrix ( 102 ) is flexible. To attach the biocompatible matrix ( 102 ) to a biological membrane, a sticking layer ( 110 ) is attached to the biocompatible matrix ( 102 ). The hydrating patch ( 100 ) can be attached in the oral cavity to alleviate dryness in a person having a dry mouth condition.

Inventors

  • Lini BASIL
  • Senthilkumar MUTHUSWAMY

Assignees

  • Lini BASIL

Dates

Publication Date
20260507
Application Date
20251229
Priority Date
20190815

Claims (16)

  1. 1 . A method of making a biodegradable hydrating patch, the method comprising: solubilizing type I atelocollagen in acetic acid and preparing an aqueous solution of type I atelocollagen; mixing an amount of aloe vera with the aqueous solution of type I collagen, wherein the amount of aloe vera added is 1 mg to 2 mg per ml of aqueous solution of type I collagen, to form an aqueous solution of absorbent matrix; pouring the aqueous solution of absorbent matrix into a mold, the aqueous solution of absorbent matrix having a thickness in the mold in the range of 4 mm to 7 mm; placing a biocompatible matrix layer on top of the aqueous solution of absorbent matrix in the mold, the biocompatible matrix layer having a flexible netted structure having pores therethrough; freeze drying by placing the filled mold in a freeze dryer to form a freeze dried absorbent inset having the biocompatible matrix thereon; demolding the freeze dried absorbent inset having the biocompatible matrix layer thereon; and adding a sticking layer to the freeze dried absorbent inset having the biocompatible matrix layer thereon to form the biodegradable hydrating patch, wherein the absorbent inset is disposed between the biocompatible matrix layer and the sticking layer.
  2. 2 . The method of claim 1 , wherein the pouring the aqueous solution of absorbent matrix into a mold is at 8 ml to 10 ml per square centimeter.
  3. 3 . The method of claim 1 , wherein the mold is placed in the freeze dryer for 24 to 48 hours.
  4. 4 . The method of claim 1 , wherein the sticking layer comprises gelatin, carboxymethyl cellulose, xanthan gum, gum Arabic, konjac gum, or combinations of one or more thereof.
  5. 5 . The method of claim 1 , wherein the sticking layer sticking layer comprises gelatin or carboxymethyl cellulose.
  6. 6 . The method of claim 1 , wherein the sticking layer sticking layer is prepared by pouring gelatin or carboxymethyl cellulose at a concentration of 1 % to 2% in distilled water into a mold and drying the sticking layer.
  7. 7 . The method of claim 6 , wherein the sticking layer is dried at 37° C. for 8 to 10 hours.
  8. 8 . The method of claim 1 , wherein the sticking layer sticking layer is reusable to allow the biodegradable hydrating patch to be removed from the oral cavity and stuck again in the oral cavity.
  9. 9 . The method of claim 1 , further comprising adding a synthetic antimicrobial agent to the aqueous solution of absorbent matrix before pouring the aqueous solution of absorbent matrix into the mold.
  10. 10 . The method of claim 9 , wherein the synthetic antimicrobial agent comprises chlorohexidine, tetracycline, amoxicillin, or any combination thereof.
  11. 11 . The method of claim 1 , wherein the absorbent inset has a shape complimentary to the netted structure of the biocompatible matrix layer.
  12. 12 . The method of claim 1 , wherein the absorbent inset comprises a cavitated substructure.
  13. 13 . The method of claim 1 , further comprising adding one or more flavoring agent to the aqueous solution of type I atelocollagen.
  14. 14 . The method of claim 13 , wherein at least one of the one or more flavoring agent is selected from L-menthol, orange oil, 4-hydroxy-2,5-dimethyl-3(2H)-furanone, and fennel oil.
  15. 15 . The method of claim 1 , wherein the type I atelocollagen comprises type I atelocollagen from bovine tendon.
  16. 16 . The method of claim 1 , wherein the type I atelocollagen comprises marine type I atelocollagen.

Description

FIELD OF THE INVENTION The present invention relates to a patch to absorb and discharge liquid. In particular the present invention relates to a patch attachable inside the oral cavity. BACKGROUND Saliva, which is secreted by salivary glands, helps to moisturize the oral cavity. In addition, the naturally secreted saliva helps to cleanse the mouth from the food particulates or foreign bodies which may be stuck on the tooth and gums. The constituents of saliva also prevent infections in the oral cavity by controlling the growth of bacteria and fungi in the mouth. Thus saliva plays an important role in maintaining the oral hygiene. In a medical condition termed as dry mouth also called as xerostomia, the secretion of saliva may be reduced or non-existent. Various causes which result in dry mouth include old age, nerve damage, smoking, chewing tobacco, and side effects of certain medications, medical treatments, and diseases. The effects of dry mouth include dryness and discomfort, increased risk of gum disease, tooth decay, mouth infections, and difficulty in wearing dentures. In addition, a person suffering from dry mouth may resort to frequent in-take of water which can result in frequent urination. Many products and techniques have been developed to address the dry mouth condition. Saliva substitutes, also known as artificial saliva, are liquid or aerosol products that are sprayed into the mouth. Alternatively, a cheek plumper with a saliva reservoir may be provided. Other solutions including chewable biomaterial, and appliance or pad with a moisturizing element to be fitted inside the mouth have been developed. For example, U.S. Pat. No. 3,991,471 by Hoops Donald, entitled “Humidifying palate” discloses a palatal appliance for maintaining humidity in the mouth and respiratory tract consisting of a rigid plastic shell which substantially conforms to hard palate. The shell has a recess in the upper portion thereof to hold a sponge which can be saturated with liquid. Apertures extending through the floor of the recess allow the liquid to flow into the mouth at a controlled rate. U.S. Pat. No. 4,917,674 of Molinoff Henry C, entitled “Mouth moisturizing device” discloses a mouth moisturizing device for treatment of an individual suffering from xerostomia comprising two mouth moisturizing pads, each of which includes at least two approximately oval shaped sponge sections placed adjacent each other of a size such that together the sponge sections just fit in a cheek pouch of the individual and an envelope or covering made of knit cotton cloth in which the sponge sections are held, and a connecting strap attached to both of the mouth moisturizing pads. Though these solutions seek to address the hydration of the dry mouth, there are other requirements that need to be considered. As the dry mouth condition requires to be addressed over a long term, the comfort of the user and the ease of usage of the technical solution is an important aspect to be accounted. The user must be able to converse freely and the time interval after which the hydrating medium needs recharging must not be short. Another important factor is hygiene. As any prolonged usage of a product inside the mouth is prone to develop microbial growth, it is desirable to use a disposable product with a reasonable life time of usage. While developing a disposable product, sufficient care to ensure that it is environment friendly and safe to dispose is also important. OBJECTS OF THE INVENTION The primary objective of the present invention is to moisturize the oral cavity and throat of a person experiencing dry mouth. Another objective is to ensure that the present invention does not create discomfort for the person when conversing. Yet another objective is to prolong the discharge time and reduce the recharging time. A desirable objective is to ensure that the present invention is an environment-friendly product which ensures hygiene during usage. SUMMARY The present invention relates to a hydrating patch comprising an absorbent inset which can absorb and retain a liquid. When subjected to pressure, the absorbed liquid is discharged from the absorbent inset. The absorbent inset is composed of a mix of two biomaterials which are biocompatible and biodegradable. A flexible biocompatible matrix provides a support for the absorbent inset. To enable attachment of the biocompatible matrix to the oral cavity muscles, a sticking layer is provided on a first side of the biocompatible matrix. The flexibility of the biocompatible matrix ensures ease of use. The biocompatible matrix with the absorbent inset is stuck to the buccal mucosa. The absorbent inset comprises a water swell-able fibrous protein and a plant based biomaterial which absorbs water during oral intake of water. When the cheek, lips, and tongue are moved, a pressure is exerted on the absorbent inset which in-turn discharges the absorbed water. The inherent antimicrobial properties of the plant extract