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US-20260124125-A1 - TOOTHPASTES DOPED WITH NANO-HYDROXYAPATITE AND ESSENTIAL OILS

US20260124125A1US 20260124125 A1US20260124125 A1US 20260124125A1US-20260124125-A1

Abstract

A toothpaste formulation having re-mineralization and antibacterial properties includes nano-hydroxyapatites in an amount of about 8 wt. % to about 12 wt. % and essential oils in an amount of about 2.8 wt. % to about 3.2 wt. % based on a total weight of the toothpaste formulation The toothpaste formulation further includes a fluoride toothpaste in an amount of about 85 wt. % to about 89 wt. % based on a total weight of the toothpaste formulation. The formulations can reverse carious lesions at the initial stage and can prevent future caries formation. Moreover, the formulations are cost effective and have reduced adverse effects.

Inventors

  • Maria IBRAHIM
  • Jehan ALHUMAID
  • Amal ALZAHRANI
  • Banin ALFARDAN
  • Shahd ALGHAMDI

Assignees

  • IMAM ABDULRAHMAN BIN FAISAL UNIVERSITY

Dates

Publication Date
20260507
Application Date
20241107

Claims (20)

  1. 1 . A toothpaste formulation, comprising: a nano-hydroxyapatite in an amount of about 8 wt. % to about 12 wt. %, an essential oil in an amount of about 2.8 wt. % to about 3.2 wt. %, wherein the essential oil is selected from the group consisting of tea tree oil, coconut oil, cinnamon oil and combinations thereof, and the balance fluoride toothpaste, wherein wt. % is based on a total weight of the toothpaste formulation, wherein a first portion of the essential oil is dissolved in the fluoride toothpaste and a second portion of the essential oil is bonded to the nano-hydroxyapatite, adsorbed on the surface of the nano-hydroxyapatite and/or dispersed in the nano-hydroxyapatite.
  2. 2 . The toothpaste formulation of claim 1 , wherein: the nano-hydroxyapatite is present in an amount of about 10 wt. %, the essential oil is tea tree oil present in an amount of about 3 wt. % and is dispersed in the nano-hydroxyapatite, and the fluoride toothpaste is present in an amount of about 87 wt. %.
  3. 3 . The toothpaste formulation of claim 1 , wherein: the nano-hydroxyapatite is present in an amount of about 10 wt. %, and the essential oil is coconut oil present in an amount of about 3 wt. % and is dispersed in the nano-hydroxyapatite, and the fluoride toothpaste is present in an amount of about 87 wt. %.
  4. 4 . The toothpaste formulation of claim 1 , wherein: the nano-hydroxyapatite is present in an amount of about 10 wt. %, and the essential oil is cinnamon oil present in an amount of about 3 wt. % and is dispersed in the nano-hydroxyapatite, and the fluoride toothpaste is present in an amount of about 87 wt. %.
  5. 5 . The toothpaste formulation of claim 1 , wherein: the essential oil is a combination of tea tree oil present in an amount of about 1.5 wt. % and coconut oil present in an amount of about 1.5 wt. %, wherein the combination is dispersed in the nano-hydroxyapatite, and the fluoride toothpaste is present in an amount in a range of about 85 wt. % to about 89 wt. %.
  6. 6 . The toothpaste formulation of claim 1 , wherein: the essential oil is a combination of tea tree oil present in an amount of about 1.5 wt. % and cinnamon oil present in an amount of about 1.5 wt. %, and the fluoride toothpaste is present in an amount in a range of about 85 wt. % to about 89 wt. %.
  7. 7 . The toothpaste formulation of claim 1 , wherein: the essential oil is a combination of cinnamon oil present in an amount of about 1.5 wt. % and coconut oil present in an amount of about 1.5 wt. %, and the fluoride toothpaste is present in an amount in a range of about 85 wt. % to about 89 wt. %.
  8. 8 . The toothpaste formulation of claim 1 , wherein: the essential oil is a combination of tea tree oil present in an amount of about 1.0 wt. %, cinnamon oil present in an amount of about 1.0 wt. % and coconut oil present in an amount of about 1.0 wt. %, and the fluoride toothpaste is present in an amount in a range of about 85 wt. % to about 89 wt. %.
  9. 9 . The toothpaste formulation of claim 1 , wherein: the nano-hydroxyapatite is present in an amount of about 8 wt. %, the essential oil is a combination of tea tree oil present in an amount of about 1.0 wt. %, cinnamon oil present in an amount of about 1.0 wt. % and coconut oil present in an amount of about 1.0 wt. %, and the fluoride toothpaste is present in an amount of about 89 wt. %.
  10. 10 . The toothpaste formulation of claim 1 , wherein: the nano-hydroxyapatite is present in an amount of about 10 wt. %, the essential oil is a combination of tea tree oil present in an amount of about 1.0 wt. %, cinnamon oil present in an amount of about 1.0 wt. % and coconut oil present in an amount of about 1.0 wt. %, and the fluoride toothpaste is present in an amount of about 87 wt. %.
  11. 11 . The toothpaste formulation of claim 1 , wherein: the nano-hydroxyapatite is present in an amount of about 12 wt. %, the essential oil is a combination of tea tree oil present in an amount of about 1.0 wt. %, cinnamon oil present in an amount of about 1.0 wt. % and coconut oil present in an amount of about 1.0 wt. %, and the fluoride toothpaste is present in an amount of about 85 wt. %.
  12. 12 . The toothpaste formulation of claim 1 , wherein the fluoride toothpaste includes sodium fluoride in an amount in a range of about 0.15 wt. %.
  13. 13 . A toothpaste formulation, consisting of: a nano-hydroxyapatite in an amount of about 8 wt. % to about 12 wt. %, an essential oil in an amount of about 2.8 wt. % to about 3.2 wt. %, wherein the essential oil is selected from the group consisting of tea tree oil, coconut oil, cinnamon oil and combinations thereof, and the balance fluoride toothpaste, wherein wt. % is based on a total weight of the toothpaste formulation, wherein a first portion of the essential oil is dissolved in the fluoride toothpaste and a second portion of the essential oil is bonded or adsorbed in the nano-hydroxyapatite.
  14. 14 . The toothpaste formulation of claim 13 , wherein: the essential oil is a combination of tea tree oil present in an amount of about 1.0 wt. %, cinnamon oil present in an amount of about 1.0 wt. % and coconut oil present in an amount of about 1.0 wt. %, and the fluoride toothpaste is present in an amount in a range of about 85 wt. % to about 89 wt. %.
  15. 15 . The toothpaste formulation of claim 13 , wherein: the nano-hydroxyapatite is present in an amount of about 10 wt. %, the essential oil is tea tree oil present in an amount of about 3 wt. %, and the fluoride toothpaste is present in an amount of about 87 wt. %.
  16. 16 . The toothpaste formulation of claim 13 , wherein: the nano-hydroxyapatite is present in an amount of about 10 wt. %, and the essential oil is coconut oil present in an amount of about 3 wt. %, and the fluoride toothpaste is present in an amount of about 87 wt. %.
  17. 17 . The toothpaste formulation of claim 13 , wherein: the nano-hydroxyapatite is present in an amount of about 10 wt. %, and the essential oil is cinnamon oil present in an amount of about 3 wt. %, and the fluoride toothpaste is present in an amount of about 87 wt. %.
  18. 18 . The toothpaste formulation of claim 13 , wherein: the essential oil is a combination of tea tree oil present in an amount of about 1.5 wt. % and coconut oil present in an amount of about 1.5 wt. %, and the fluoride toothpaste is present in an amount in a range of about 85 wt. % to about 89 wt. %.
  19. 19 . The toothpaste formulation of claim 1 , wherein: the essential oil is a combination of tea tree oil present in an amount of about 1.5 wt. % and cinnamon oil present in an amount of about 1.5 wt. %, and the fluoride toothpaste is present in an amount in a range of about 85 wt. % to about 89 wt. %.
  20. 20 . A method of formulating an antibiotic, remineralizing toothpaste, comprising: mixing an essential oil in an amount of about 2.8 wt. % to about 3.2 wt. %, wherein the essential oil is selected from the group consisting of tea tree oil, coconut oil, cinnamon oil and combinations thereof, with a nano-hydroxyapatite in an amount of about 8 wt. % to about 12 wt. % to form a first mixture, and mixing a fluoride toothpaste in an amount of about 85 wt. % to about 89 wt. % into the first mixture to form a second mixture, wherein a first portion of the essential oil is dissolved in the fluoride toothpaste and a second portion of the essential oil is bonded or adsorbed in the nano-hydroxyapatite, and sterilizing the second mixture under ultraviolet lighting.

Description

BACKGROUND Technical Field The present disclosure is directed to toothpaste formulations, particularly toothpaste formulations including a combination of nano-hydroxyapatite, fluoride, and essential oils, which attribute re-mineralizing and antibacterial properties to the formulations. Description of Related Art The “background” description provided herein is for the purpose of generally presenting the context of the disclosure. Work of the presently named inventors, to the extent it is described in this background section, as well as aspects of the description which may not otherwise qualify as prior art at the time of filing, are neither expressly or impliedly admitted as prior art against the present invention. Toothpaste is a commonly used product for maintaining oral hygiene and the health of the gums and the teeth. Various ingredients such as abrasives, binding agents, humectants, surfactants, and fluorides are typically added to toothpaste formulations to impart better cleansing and physical properties. Many toothpaste formulations contain fluoride which helps to protect the enamel layer present on the teeth and also possess anti-caries properties. Additionally, various other ingredients, each having a specific function, are also added to the toothpaste formulations. Such ingredients include flavoring agents, coloring agents, anti-bacterial agents, sweetening agents, and the like. In addition to having desirable physical properties such as easy flow and smooth texture, toothpaste formulations with medicinal effects and repairing functions are preferred. Over time, dental erosion occurs, leading to enamel loss and rendering the teeth hypersensitive to temperature, texture, or taste of food while chewing or drinking. Dental erosions also result in tooth caries and cavities. In this regard, various toothpaste formulations that help in preventing and curing dental erosions are being developed. Some of these include components that are also present in the human teeth, one such component being hydroxyapatite. Hydroxyapatites form an integral part of the mineral composition of human teeth and are also used in toothpaste formulations for their remineralization effects. These hydroxyapatites are prepared at the nano level to form nanohydroxyapatites (nHA) that closely resemble the structure and composition of tooth enamel and, hence, are a preferable choice for tooth remineralization and preventing and curing tooth sensitivity and decay. Many toothpaste formulations having nanohydroxyapatite are currently being launched and used. Generally, toothpastes also include anti-bacterial agents to prevent dental caries and infections. These anti-bacterial agents are mostly chemical in nature. One such agent is triclosan, which is commonly used in toothpastes. Other commonly used anti-bacterial agents include chlorhexidine, metal salts, and quaternary ammonium compounds such as benzalkonium chloride. To avoid side effects, herbal and chemical-free anti-bacterial agents are currently added to toothpaste. Compounds derived from plants are preferred. Such compounds may be phytochemicals containing saponins, tannins, phenolic compounds, flavonoids and the likes. Essential oils derived from plants are also included in toothpastes. A recent trend in toothpaste research is towards developing compositions which have fewer chemicals and no adverse effects. US20210378945A1 describes a toothpaste including nano-hydroxyapatite in an amount of 3-40 % by mass of the toothpaste and tea tree oil in an amount of 0.10-1.0% by mass of the toothpaste, aloe in an amount of 5.0-37.0% by mass of the toothpaste, xylitol in an amount of 5.0-40.0% by mass of the toothpaste, silicon dioxide in an amount of 3.0-12.0% by mass of the toothpaste. US20170189287A1 describes a tooth cleaning composition including a wax and a calcium phosphate. The calcium phosphate is present in the form of hydroxyapatite in a content of 0.001 to 33% by mass and the wax is present in a content of 0.0001 to 30% by mass. US20230114022A1 describes a toothpaste including nano-hydroxyapatite in a range of 0.025% w/w to 70% w/w, coconut oil, tea tree oil and cinnamon bark oil in an amount of 0.05-10% v/w. CN115624499A describes a whitening anti-allergic toothpaste including 4-12 % of nano-hydroxyapatite, 0.5-5% of chitosan oligosaccharide, 0.1-0.5% of lactoferrin, 0.01-0.5% of biological lysozyme, 0.5-3% of cinnamon extract, 0.5-5% of honeysuckle extract, 0.1-0.5% of dendrobium officinale extract, 0.1-0.5% of propolis, 0.5-3% of polyethylene glycol, 0.3-0.6% of xanthan gum, 0.1-0.5% of probiotics, 0.1-0.5% of phytic acid, 0.1-0.5% of xylitol and 0.05-0% of triclosan 15%, purified water margin. CN105640788A describes a hydroxyapatite toothpaste including nanohydroxyapatite in a mass content of not more than 20% and fluoride in a mass content of not more than 8.0 wt. %. Each of the aforementioned patent literature suffers from one or more drawbacks hindering their adoption, s