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US-20260124126-A1 - BIOACTIVE GLASS CONTAINING DENTIFRICE FORMULATIONS

US20260124126A1US 20260124126 A1US20260124126 A1US 20260124126A1US-20260124126-A1

Abstract

A dentifrice formulation includes a solvent, a humectant, and a bioactive glass. The bioactive glass includes greater than or equal to 15 wt % and less than or equal to 45 wt % SiO 2 , greater than or equal to 30 wt % and less than or equal to 60 wt % CaO, greater than or equal to 8 wt % and less than or equal to 30 wt % P 2 O 5 , and greater than or equal to 2 wt % and less than or equal to 15 wt % ZrO 2 .

Inventors

  • Qiang Fu
  • Nicholas Michael Stone-Weiss

Assignees

  • CORNING INCORPORATED

Dates

Publication Date
20260507
Application Date
20231102

Claims (20)

  1. 1 . A dentifrice formulation comprising: a solvent; a humectant; and a bioactive glass, wherein the bioactive glass comprises: greater than or equal to 15 wt % and less than or equal to 45 wt % SiO 2 , greater than or equal to 30 wt % and less than or equal to 60 wt % CaO, greater than or equal to 8 wt % and less than or equal to 30 wt % P 2 O 5 , and greater than or equal to 2 wt % and less than or equal to 15 wt % ZrO 2 .
  2. 2 . The dentifrice formulation of claim 1 , wherein the bioactive glass comprises: greater than or equal to 20.0 wt % and less than or equal to 39.5 wt % SiO 2 ; greater than or equal to 0.0 wt % and less than or equal to 14.5 wt % MgO; greater than or equal to 32.5 wt % and less than or equal to 47.0 wt % CaO; greater than or equal to 0.0 wt % and less than or equal to 14.5 wt % SrO; greater than or equal to 0.0 wt % and less than or equal to 14.5 wt % ZnO; greater than or equal to 9.5 wt % and less than or equal to 24.5 wt % P 2 O 5 ; and greater than or equal to 4.0 wt % and less than or equal to 10.0 wt % ZrO 2 .
  3. 3 . The dentifrice formulation of claim 1 , wherein the bioactive glass has a weight loss that is less than or equal to 5 wt % after 7 days of exposure in deionized water.
  4. 4 . The dentifrice formulation of claim 1 , wherein the solvent is an aqueous solvent.
  5. 5 . The dentifrice formulation of claim 1 , wherein the solvent is a non-aqueous solvent.
  6. 6 . The dentifrice formulation of claim 5 , wherein the solvent is glycerin.
  7. 7 . The dentifrice formulation of claim 1 , wherein the dentifrice formulation comprises: greater than or equal to 1 wt % and less than or equal to 20 wt % solvent; greater than or equal to 2 wt % and less than or equal to 50 wt % humectant; and greater than or equal to 1 wt % and less than or equal to 20 wt % bioactive glass.
  8. 8 . The dentifrice formulation of claim 1 , wherein the humectant is a short-chained polyalcohol selected from the group consisting of glycerol, sorbitol, propylene glycol, and polyethylene glycol.
  9. 9 . The dentifrice formulation of claim 1 , further comprising one or more of a fluoride ion source, a flavoring, a surfactant, a sweetener, a whitening agent, and an abrasive.
  10. 10 . The dentifrice formulation of claim 9 , wherein the dentifrice formulation comprises a fluoride ion source selected from the group consisting of sodium fluoride, potassium fluoride, ammonium fluoride, monofluorophosphates, and mixtures thereof.
  11. 11 . The dentifrice formulation of claim 10 , wherein the dentifrice formulation comprises greater than or equal to 0.01 wt % and less than or equal to 1.00 wt % of fluoride ions.
  12. 12 . The dentifrice formulation of claim 9 , wherein the dentifrice formulation comprises greater than or equal to 0.05 wt % and less than or equal to 5.00 wt % flavoring.
  13. 13 . The dentifrice formulation of claim 9 , wherein the dentifrice formulation comprises a surfactant selected from the group consisting of sodium lauryl sulfate, poloxamer, and mixtures thereof.
  14. 14 . The dentifrice formulation of claim 13 , wherein the dentifrice formulation comprises greater than or equal to 0.1 wt % and less than or equal to 5.0 wt % surfactant.
  15. 15 . The dentifrice formulation of claim 9 , wherein the dentifrice formulation comprises greater than or equal to 0.1 wt % and less than or equal to 5.0 wt % sweetener.
  16. 16 . The dentifrice formulation of claim 9 , wherein the dentifrice formulation comprises a whitening agent selected from the group consisting of titanium dioxide, hydrogen peroxide, sodium tripolyphosphates, and mixtures thereof.
  17. 17 . The dentifrice formulation of claim 16 , wherein the dentifrice formulation comprises greater than or equal to 0.1 wt % and less than or equal to 2.0 wt % whitening agents.
  18. 18 . The dentifrice formulation of claim 9 , wherein the dentifrice formulation comprises an abrasive selected from the group consisting of silica, zinc orthophosphate, sodium bicarbonate, alumina, calcium carbonate, calcium pyrophosphate, and mixtures thereof.
  19. 19 . The dentifrice formulation of claim 18 , wherein the dentifrice formulation comprises greater than or equal to 0.1 wt % and less than or equal to 20.0 wt % abrasives.
  20. 20 . The dentifrice formulation of claim 1 , wherein the dentifrice formulation comprises: greater than or equal to 2 wt % and less than or equal to 15 wt % bioactive glass; greater than or equal to 30 wt % and less than or equal to 45 wt % solvent; greater than or equal to 40 wt % and less than or equal to 50 wt % humectant; greater than or equal to 0.2 wt % and less than or equal to 1.0 wt % fluoride ions; greater than or equal to 0.5 wt % and less than or equal to 1.5 wt % flavoring; greater than or equal to 0.5 wt % and less than or equal to 1.5 wt % surfactant; greater than or equal to 0.1 wt % and less than or equal to 0.5 wt % sweetener; greater than or equal to 2 wt % and less than or equal to 8 wt % abrasives; and greater than or equal to 0.1 wt % and less than or equal to 0.5 wt % whitening agents.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS This application claims the benefit of priority under 35 U.S.C. § 119 of U.S. Provisional Application No. 63/423,906 filed Nov. 9, 2022, the content of which is incorporated herein by reference in its entirety. BACKGROUND Field The present specification generally relates to bioactive glass and, more specifically, to dentifrice formulations containing the bioactive glass. Technical Background Oral diseases pose a major health burden worldwide and affect nearly 3.5 billion people throughout their lifetime, causing pain, discomfort, disfigurement, and even death. Globally, it is estimated that 2.3 billion people suffer from caries of permanent teeth and more than 530 million children suffer from caries of primary teeth. The dissolution of apatite crystals and the net loss of calcium, phosphate and other ions from the tooth (demineralization) accounts for the formation of dental caries. The caries can be managed non-invasively through a remineralization process, in which calcium and phosphate ions are supplied from an external source to the tooth to promote crystal deposition into voids in demineralized enamel. Calcium phosphate phases in both crystalline (brushite, β-tricalcium phosphate, octocalcium phosphate, hydroxyapatite, fluorapatite and enamel apatite) and amorphous forms have been used in the remineralization process. Among these materials, amorphous calcium phosphate (bioactive glass) has shown the most promising evidence in the remineralization process. There is a strong desire to develop new bioactive glass compositions that can promote the remineralization process to prevent or repair tooth caries. SUMMARY According to embodiments, a dentifrice formulation comprises: a solvent; a humectant; and a bioactive glass, wherein the bioactive glass comprises: greater than or equal to 15 wt % and less than or equal to 45 wt % SiO2, greater than or equal to 30 wt % and less than or equal to 60 wt % CaO, greater than or equal to 8 wt % and less than or equal to 30 wt % P2O5, and greater than or equal to 2 wt % and less than or equal to 15 wt % ZrO2. According to one or more embodiments, a dentifrice formulation comprises a solvent; a humectant; and a bioactive glass, wherein the bioactive glass comprises: greater than or equal to 20.0 wt % and less than or equal to 39.5 wt % SiO2; greater than or equal to 0.0 wt % and less than or equal to 14.5 wt % MgO; greater than or equal to 32.5 wt % and less than or equal to 47.0 wt % CaO; greater than or equal to 0.0 wt % and less than or equal to 14.5 wt % SrO; greater than or equal to 0.0 wt % and less than or equal to 14.5 wt % ZnO; greater than or equal to 9.5 wt % and less than or equal to 24.5 wt % P2O5; and greater than or equal to 4.0 wt % and less than or equal to 10.0 wt % ZrO2. According to one or more embodiments, a dentifrice formulation comprises: greater than or equal to 2 wt % and less than or equal to 15 wt % bioactive glass; greater than or equal to 30 wt % and less than or equal to 45 wt % solvent; greater than or equal to 40 wt % and less than or equal to 50 wt % humectant; greater than or equal to 0.2 wt % and less than or equal to 1.0 wt % fluoride ions; greater than or equal to 0.5 wt % and less than or equal to 5.0 wt % flavoring; greater than or equal to 0.5 wt % and less than or equal to 1.5 wt % surfactant; greater than or equal to 0.1 wt % and less than or equal to 0.5 wt % sweetener; greater than or equal to 2 wt % and less than or equal to 8 wt % abrasives; and greater than or equal to 0.1 wt % and less than or equal to 0.5 wt % whitening agents. Additional features and advantages will be set forth in the detailed description, which follows, and in part will be readily apparent to those skilled in the art from that description or recognized by practicing the embodiments described herein, including the detailed description, which follows, the claims, as well as the appended drawings. It is to be understood that both the foregoing general description and the following detailed description describe various embodiments and are intended to provide an overview or framework for understanding the nature and character of the claimed subject matter. The accompanying drawings are included to provide a further understanding of the various embodiments, and are incorporated into and constitute a part of this specification. The drawings illustrate the various embodiments described herein, and together with the description serve to explain the principles and operations of the claimed subject matter. BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 graphically depicts weight loss versus time of bioactive glass compositions according to embodiments disclosed and described herein and conventional glass compositions in water; FIG. 2 graphically depicts weight loss versus time of bioactive glass compositions according to embodiments disclosed and described herein and conventional glass compositions in artificial saliva; FIG. 3 i