US-20260124132-A1 - COMPOSITION AND METHOD FOR INHIBITING COLLAGENASE ACTIVITY

Abstract

A composition for administration to a subject is disclosed. The composition comprises at least one botanical active component. The botanical active component is present in the composition in an amount effective to inhibit collagenase activity in the skin of the subject. The botanical active component comprises at least one extract selected from the group consisting of: i) an extract of Potentilla glabra leaf; ii) an extract of Bombax malabaricum flower; iii) an extract of Amomum kravanh fruit; iv) an extract of Cornus officinalis fruit; and v) combinations of i) to iv). The composition may be in the form of a topical composition, e.g., for topical application. The composition may also be in the form of an oral composition, e.g., for ingestion. A method of inhibiting collagenase activity in the skin of a subject is also provided. The method comprises administering an effective amount of the composition to the subject.

Inventors

• Huiji ZHOU
• Bo Li
• Tingzhao Li
• Qiming Wu
• Xiuyu JIANG

Assignees

• ACCESS BUSINESS GROUP INTERNATIONAL LLC

Dates

Publication Date

20260507

Application Date

20230831

Priority Date

20220905

Claims (20)

1. 1 . A composition for administration to a subject, the composition comprising at least one botanical active component, wherein the botanical active component comprises at least one extract selected from the group consisting of: i) an extract of Potentilla glabra leaf; ii) an extract of Bombax malabaricum flower; iii) an extract of Amomum kravanh fruit; iv) an extract of Cornus officinalis fruit; and v) combinations of i) to iv); wherein the botanical active component is present in the composition in an amount effective to inhibit collagenase activity in skin of the subject.
2. 2 . The composition according to claim 1 , wherein the botanical active component comprises the extract of Potentilla glabra leaf, optionally wherein the botanical active component consists of the extract of Potentilla glabra leaf.
3. 3 . The composition according to claim 1 , wherein the extract of Potentilla glabra leaf is obtained by alcohol extracting, optionally ethanol extracting, leaves or leaf-based plant material of Potentilla glabra.
4. 4 . The composition according to claim 1 , wherein the extract of Potentilla glabra leaf is obtained by water extracting (or aqueous extracting) leaves or leaf-based plant material of Potentilla glabra.
5. 5 . The composition according to claim 1 , wherein the composition is substantially to completely free of components obtained from non-leaf-based plant material of Potentilla glabra.
6. 6 . The composition according to claim 1 , wherein the botanical active component comprises the extract of Bombax malabaricum flower, optionally wherein the botanical active component consists of the extract of Bombax malabaricum flower.
7. 7 . The composition according to claim 1 , wherein the extract of Bombax malabaricum flower is obtained by alcohol extracting, optionally ethanol extracting, flowers or flower-based plant material of Bombax malabaricum.
8. 8 . The composition according to claim 1 , wherein the extract of Bombax malabaricum flower is obtained by water extracting (or aqueous extracting) flowers or flower-based plant material of Bombax malabaricum.
9. 9 . The composition according to claim 1 , wherein the composition is substantially to completely free of components obtained from non-flower-based plant material of Bombax malabaricum.
10. 10 . The composition according to claim 1 , wherein the botanical active component comprises the extract of Amomum kravanh fruit, optionally wherein the botanical active component consists of the extract of Amomum kravanh fruit.
11. 11 . The composition according to claim 1 , wherein the extract of Amomum kravanh fruit is obtained by alcohol extracting, optionally ethanol extracting, fruit or fruit-based plant material of Amomum kravanh.
12. 12 . The composition according to claim 1 , wherein the extract of Amomum kravanh fruit is obtained by water extracting (or aqueous extracting) fruit or fruit-based plant material of Amomum kravanh.
13. 13 . The composition according to claim 1 , wherein the composition is substantially to completely free of components obtained from non-fruit-based plant material of Amomum kravanh.
14. 14 . The composition according to claim 1 , wherein the botanical active component comprises the extract of Cornus officinalis fruit, optionally wherein the extract of Cornus officinalis is further defined as an extract of Cornus officinalis fruit.
15. 15 . The composition according to claim 1 , wherein the extract of Cornus officinalis fruit is obtained by alcohol extracting, optionally ethanol extracting, fruit or fruit-based plant material of Cornus officinalis.
16. 16 . The composition according to claim 1 , wherein the extract of Cornus officinalis fruit is obtained by water extracting (or aqueous extracting) fruit or fruit-based plant material of Cornus officinalis.
17. 17 . The composition according to claim 1 , wherein the composition is substantially to completely free of components obtained from non-fruit-based plant material of Cornus officinalis.
18. 18 . The composition according to claim 1 , wherein the composition is further defined as a topical composition that is formulated for topical administration to the subject.
19. 19 . The composition according to claim 18 , further comprising a cosmetically acceptable carrier, optionally wherein the cosmetically acceptable carrier is not naturally occurring.
20. 20 . (canceled)

Description

CROSS-REFERENCE TO RELATED APPLICATIONS This application claims priority to and all advantages of Chinese Application No. 202211079023.7 filed on 5 Sep. 2022, the contents of which is incorporated herein by reference in its entirety. FIELD OF THE INVENTION The present invention relates generally to compositions and methods for inhibiting collagenase activity and, more specifically, to a botanical extract-containing composition for inhibiting collagenase activity in skin of a subject. Related methods are also provided. BACKGROUND OF THE INVENTION Collagen, a fibrous extracellular matrix protein, is a major component in the connective tissue of the human body and constitutes approximately 3-6% of total tissue protein in the body. The functional properties of the skin depend on the integrity of collagen in the dermis. Collagen deposition is finely controlled and depends on the physiological status of the body, and changes in the rate of deposition that occur during wound healing, the development of new bone, and aging. Thus, the control of collagen metabolism may be useful for various therapeutic and cosmetic applications. Recently, bioactive molecules from plants have been widely used as cosmeceutical ingredients because of their prime property to slow down the rate of intrinsic skin aging processes and diverged the extrinsic ones. Several natural products and extracts have been reported for the development of anti-aging skin care products. For instance, polyphenols from green tea such as epigallocatechin gallate (EGCG) has been formulated for anti-aging skin care products that exhibit restrained collagenase inhibition. In view of the foregoing, there remains an opportunity to provide new and useful collagenase inhibitors. Such inhibitors can offer potential preventive and therapeutic approaches for reducing skin aging, such as wrinkle formation, caused by collagenase. As such, there also remains an opportunity to provide new and useful compositions and methods for inhibiting collagenase activity. BRIEF SUMMARY OF THE INVENTION A composition for administration to a subject is provided. The composition comprises at least one botanical active component. The botanical active component is generally present in the composition in an amount effective to inhibit collagenase in the skin of the subject. The botanical active component comprises at least one extract selected from the group consisting of: i) an extract of Potentilla glabra leaf; ii) an extract of Bombax malabaricum flower; iii) an extract of Amomum kravanh seed; iv) an extract of Cornus officinalis fruit; and v) combinations of i) to iv). In various embodiments, the composition is a topical composition that is formulated for topical administration to the subject. In other embodiments, the composition is an oral composition that is formulated for oral administration to the subject. The composition can be used for inhibiting collagenase in the skin of a subject. A method of inhibiting collagenase in the skin of a subject comprises administering an effective amount of the composition to the subject. BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a plot showing the average inhibition rate of collagenase using Cornus officinalis Sieb.et Zucc. (fruit)—aqueous extract; FIG. 2 is a plot showing the average inhibition rate of collagenase using Cornus officinalis Sieb.et Zucc. (fruit)—ethanol extract; FIG. 3 is a plot showing the average inhibition rate of collagenase using Potentilla glabra Lodd. var. mandshurica (Maxim.) Hand.-Mazz (leaf)—aqueous extract; FIG. 4 is a plot showing the average inhibition rate of collagenase using Potentilla glabra Lodd. var. mandshurica (Maxim.) Hand.-Mazz (leaf)—ethanol extract; FIG. 5 is a plot showing the average inhibition rate of collagenase using Amomum kravanh Pierre ex Gagnep—aqueous extract; FIG. 6 is a plot showing the average inhibition rate of collagenase using Amomum kravanh Pierre ex Gagnep—ethanol extract; FIG. 7 is a plot showing the average inhibition rate of collagenase using Bombax ceiba Linnaeus (Bombax malabaricum) (flower)—aqueous extract; FIG. 8 is a plot showing the average inhibition rate of collagenase using Bombax ceiba Linnaeus (Bombax malabaricum) (flower)—ethanol extract; and FIG. 9 is a plot showing the average inhibition rate of collagenase using EGCG as a control. DETAILED DESCRIPTION OF THE CURRENT EMBODIMENTS A composition for administration to a subject is disclosed. The composition comprises at least one botanical active component. The composition is described below, followed by description of associated uses and methods. As will be understood in view of this disclosure, the composition is not particularly limited aside from the botanical active component and, in particular, the extract(s) thereof, as well as the related components and methods. As such, the composition may be formulated, for example, as a topical composition (e.g., a cosmetic composition), or as an oral composition or as a nutraceu