US-20260124166-A1 - COMPOSITIONS AND METHODS USING GLYCINE TO REDUCE BIOLOGICAL AGE OF AN ADULT ANIMAL

Abstract

The present disclosure generally relates to compositions and methods to reduce the biological age and/or reduce the rate of increase of the biological age of an adult animal. More specifically, the present disclosure relates to administering a formulation comprising an effective amount of glycine and/or functional derivatives, alone or in combination with a dietary regime such as caloric restriction, senior diet or low protein diet. The formulation can concomitantly reduce the biological age of a tissue, organ or physiological system in the adult animal in need; or treat, prevent, or delay the onset of an organ disease, or decline of organ function, or condition relating thereto in an adult animal in need.

Inventors

• Gabriele Civiletto
• GIULIA LIZZO
• Philipp Gut
• LORANE TEXARI

Assignees

• Société des Produits Nestlé S.A.

Dates

Publication Date

20260507

Application Date

20231103

Priority Date

20221107

Claims (15)

1. 1 . A method for reducing the biological age and/or reduce the rate of increase of the biological age of an adult animal in need, the method comprising: feeding the adult animal a composition comprising an effective amount of glycine and/or functional derivatives.
2. 2 . A method according to claim 1 , wherein the feeding reduces the biological age of a tissue, organ or physiological system in the adult animal in need,
3. 3 . A method according to claim 2 , wherein the tissue, organ or physiological system is immune, gastrointestinal, urinary, muscular, cardiovascular, and/or neurological system.
4. 4 . A method according to claim 2 , wherein the tissue is one having a deficiency in glycine.
5. 5 . A method according to claim 2 , wherein the tissue is skeletal muscle.
6. 6 . A method according to claim 1 , wherein the glycine is N-acetylcysteinylglycine (GlyNAC).
7. 7 . A method according to claim 1 , wherein the feeding treats, prevents, or delays the onset of an organ disease, or decline of organ function, or condition relating thereto in the adult animal in need.
8. 8 . A method according to claim 7 , wherein the animal in need has a deficiency in glycine in one or more of its tissue.
9. 9 . A method according to claim 1 , wherein the animal in need has an increased biological age compared to its chronological age.
10. 10 . A method according to claim 9 , wherein the increased biological age is determined from the DNA methylation profile of the adult animal.
11. 11 . A method according to claim 1 , wherein the animal is an ageing animal.
12. 12 . A method according to claim 1 , wherein the animal is a dog or a cat.
13. 13 . A method according to claim 1 , wherein the animal is a human.
14. 14 . A method according to claim 1 , wherein the composition is selected from the group consisting of food compositions, dietary supplements, nutritional compositions, nutraceuticals, powdered nutritional products to be reconstituted in water or milk before consumption, food additives, medicaments, drinks, dry or wet petfood and combinations thereof.
15. 15 . A method according to claim 1 , wherein the composition is part of, or administered together with; a dietary regime selected from a calorie-restricted diet, a senior diet or a low protein diet.

Description

CROSS REFERENCE TO RELATED APPLICATIONS This application claims priority to European application No. 22205778.8 filed Nov. 7, 2022 and PCT/EP 2023/080623 application filed Nov. 3, 2023, the disclosure of which is incorporated in its entirety herein by this reference. BACKGROUND TO THE INVENTION The present disclosure generally relates to compositions and methods to reduce the biological age and/or reduce the rate of increase of the biological age of an adult animal. More specifically, the present disclosure relates to administering a formulation comprising an effective amount of glycine and/or functional derivatives, alone or in combination with a dietary regime such as caloric restriction, senior diet or low protein diet. The formulation can concomitantly reduce the biological age of a tissue, organ or physiological system in the adult animal in need; or treat, prevent, or delay the onset of an organ disease, or decline of organ function, or condition relating thereto in an adult animal in need. Chronological age is known to be a major indicator of general health status, with increasing chronological age associated with reduced health. However, depending on genetics, nutrition, and lifestyles, individuals may age slower or faster than their chronological age. Chronological age may therefore not always reflect an individual's rate of aging or risk of reduced health. On the other hand, the biological age of an individual (based on e.g. clinical biochemistry and cell biology measures) can vary compared to others of the same chronological age. Highly digestible and high-quality protein diets are generally recommended based upon the chronological age of a dog. For example, it may be recommended that a dog is switched to a senior diet around 7 or 8 years old. However, the determination of an increased biological age for a dog compared to its chronological age may allow a determination to provide additional nutritional solution to the animal. There is thus a need for methods and compositions effective in reducing biological age and conditions related thereto, of an adult animal having an increased biological age compared to its chronological age. SUMMARY OF THE INVENTION The inventors surprisingly found that glycine induces reduction in biological age at the individual level and at tissue level. Accordingly, in a general embodiment, the present disclosure provides a method for reducing the biological age and/or reduce the rate of increase of the biological age of an adult animal in need, the method comprising: feeding the adult animal a composition comprising an effective amount of glycine and/or functional derivatives. The present disclosure also provides a method for reducing the biological age of a tissue, organ or physiological system in an adult animal in need, the method comprising feeding the adult animal a composition comprising an effective amount of glycine and/or functional derivatives. The present disclosure further provides a method for treating, preventing, or delaying the onset of an organ disease, or decline of organ function, or condition relating thereto in an adult animal in need, the method comprising feeding the adult animal a composition comprising an effective amount of glycine and/or functional derivatives. Suitably, the present methods may comprise selecting and/or applying the composition comprising an effective amount of glycine and/or functional derivatives to an animal following a determination that the animal's biological age is greater than its chronological age. The increased biological age may be in a tissue, in an organ or in a physiological system such that immune, gastrointestinal, urinary, muscular, cardiovascular, and/or neurological system. In an embodiment, the tissue is one having a deficiency in glycine. Suitably, improving the biological age of an animal may refer to a reduction in the difference between the biological age and chronological age of the animal, where the biological age of the animal is greater than its chronological age. Alternatively, a worsening in the biological age of an animal may refer to an increase in the difference between the biological age and chronological age of the animal, where the biological age of the animal is greater than its chronological age. Suitably, improving the biological age of an animal may refer to a reduction in the rate of change between the biological age and chronological age of the animal, where the biological age of the animal is greater than its chronological age. For example, an animal's biological age may have been increasing by 1.5 years per 1 year increase in chronological age. Suitably, whilst the present composition may be effective for animals based on chronological age, it may be particularly effective when applied to an animal with an increased biological age compared to its chronological age. As such, the present method may advantageously be beneficial for an animal that has an increased likelihood to respond,