US-20260124237-A1 - CARTILAGE REGENERATION COMPOSITION

Abstract

The purpose of the present invention is to provide a cartilage regeneration promoter. The cartilage regeneration promoter includes (A) hydroxycitric acid and/or a salt thereof, and (B) a sugar selected from the group consisting of chondroitin sulfate and a salt thereof, hyaluronic acid and a salt thereof, a proteoglycan, and the constituent sugar of the above sugars, and is capable of promoting cartilage regeneration.

Inventors

• Yoshiyuki Mizushina
• Junya Toguchida
• Yonghui Jin

Assignees

• KOBAYASHI PHARMACEUTICAL CO., LTD.
• KYOTO UNIVERSITY

Dates

Publication Date

20260507

Application Date

20221031

Priority Date

20211101

Claims (12)

1. 1 . A cartilage regeneration promoter comprising: (A) hydroxycitric acid and/or a salt of hydroxycitric acid; and (B) a sugar selected from a group consisting of chondroitin sulfate and a salt of chondroitin sulfate, a proteoglycan, hyaluronic acid and a salt of hyaluronic acid, and a constituent sugar of the above sugars.
2. 2 . The cartilage regeneration promoter according to claim 1 , wherein the constituent sugar is an optionally N-acetylated hexosamine selected from a group consisting of glucosamine, N-acetylglucosamine, N-acetylglucosamine sulfate and a salt of N-acetylglucosamine sulfate, galactosamine, N-acetylgalactosamine, and N-acetylgalactosamine sulfate and a salt of N-acetylgalactosamine sulfate.
3. 3 . The cartilage regeneration promoter according to claim 1 , wherein the component (B) is contained in a total amount of 0.001 to 6 parts by weight with respect to 1 part by weight of the component (A) in a total amount in terms of hydroxycitric acid.
4. 4 . The cartilage regeneration promoter according to claim 1 , including a plant extract containing the component (A).
5. 5 . The cartilage regeneration promoter according to claim 4 , wherein the plant extract is a garcinia extract.
6. 6 . The cartilage regeneration promoter according to claim 4 , wherein the component (B) is contained in a total amount of 0.0015 to 10 parts by weight with respect to 1 part by weight of the plant extract.
7. 7 . The cartilage regeneration promoter according to claim 1 , wherein the component (B) is chondroitin sulfate.
8. 8 . A method of promoting for differentiation from undifferentiated cells to cartilaginous cells, the method comprising administering the cartilage regeneration promoter according to claim 1 to the undifferentiated cells.
9. 9 . A method of treating knee osteoarthritis comprising administering the cartilage regeneration promoter according to claim 1 to a subject.
10. 10 . A method of inhibiting cartilage degradation inhibitor comprising administering the cartilage regeneration promoter according to claim 1 to cartilage.
11. 11 . A method of maintaining cartilage thickness comprising administering the cartilage regeneration promoter according to claim 1 to cartilage.
12. 12 . An method of alleviating joint pain, joint uneasiness, and/or joint displeasure comprising administering the cartilage regeneration promoter according to claim 1 to a subject.

Description

TECHNICAL FIELD The present invention relates to a cartilage regeneration composition. BACKGROUND ART Joint pain due to cartilage disorder such as osteoarthritis caused by retrograde degeneration of cartilage, cartilage damage due to trauma, or the like is a major factor that restricts daily life activities, and in an aging society, coping with the joint pain is an increasingly important problem. There is no fundamental conservative treatment for cartilage disorder, and oral administration of a nonsteroidal anti-inflammatory drug (NSAID) or intra-articular injection of a steroid is used as a symptomatic treatment for pain. In addition, intra-articular injection of hyaluronic acid, which is an important component of cartilage and one of glycosaminoglycans (GAG), has also been widely performed, and a certain effect on pain has been observed, but the effect on cartilage regeneration is uncertain. Glucosamine is one of the amino sugars constituting GAG. Glucosamine is contained in the cell walls of crustaceans such as shrimps and crabs, insects such as beetles, and fungi, and is a kind of monosaccharide that is widely present in nature as a constituent unit of chitin. In addition, glucosamine has been studied for its important roles in vivo: for example, glucosamine is present as a constituent sugar of mucopolysaccharides in vivo. Glucosamine not only serves as a component of cartilage and connective tissue. It has been also reported that glucosamine has an anti-inflammatory action via neutrophils and serves as an effective component for arthritis (Patent Document 1). It is not clear how much orally ingested glucosamine can be involved in the metabolism of articular cartilage. However, attempts have been made to actively utilize glucosamine in foods, quasi-pharmaceutical products, or pharmaceutical products for the purpose of a therapeutic or preventive effect of cartilage disorder. For example, a composition for ameliorating joint pain containing collagen, methylsulfonylmethane, glucosamine, and chondroitin, the composition containing collagen in an intake amount of 2000 mg or more per day has been proposed as a composition for ameliorating joint pain, an agent for ameliorating joint pain, or a food capable of reducing, treating, and preventing symptoms of joint pain such as arthritis (Patent Document 2). On the other hand, it is known that hydroxycitric acid contained in the pericarp of garcinia suppresses the excess intake of carbohydrates from being stored as body fat, and promotes the consumption of fat. In addition, it has been reported that fat metabolism can be more effectively promoted by using a composition in which caffeine is combined with a garcinia extract (Patent Document 3). PRIOR ART DOCUMENT Patent Documents Patent Document 1: Japanese Unexamined Patent Application Publication No. 2004-529860 Patent Document 2: Japanese Patent Laid-open Publication No. 2009-051833 Patent Document 3: Japanese Patent Laid-open Publication No. 2001-258506 SUMMARY OF THE INVENTION Problems to be Solved by the Invention The effect of glucosamine in treatment or prevention of cartilage disorders has attracted attention, and various glucosamine-containing compositions have been studied, but the effect is not yet at a sufficient level. Therefore, the present inventors have considered that a component having an action to promote cartilage regeneration is expected to have a further effect in treatment or prevention of cartilage disorder. An object of the present invention is to provide a cartilage regeneration promoter having an excellent cartilage regeneration-promoting action. Means for Solving the Problem The present inventors have found that an excellent cartilage regeneration-promoting action is exhibited by combining hydroxycitric acid and/or a salt thereof with a predetermined cartilage component. The present invention has been completed by further conducting studies based on such findings. That is, the present invention provides inventions of the following aspects. Item 1. A cartilage regeneration promoter (cartilage regeneration composition) including: (A) hydroxycitric acid and/or a salt of hydroxycitric acid; and (B) a sugar selected from a group consisting of chondroitin sulfate and a salt of chondroitin sulfate, a proteoglycan, hyaluronic acid and a salt of hyaluronic acid, and a constituent sugar of the above sugars. Item 2. The cartilage regeneration promoter according to Item 1, in which the constituent sugar is an optionally N-acetylated hexosamine selected from a group consisting of glucosamine, N-acetylglucosamine, N-acetylglucosamine sulfate and a salt of N-acetylglucosamine sulfate, galactosamine, N-acetylgalactosamine, and N-acetylgalactosamine sulfate and a salt of N-acetylgalactosamine sulfate. Item 3. The cartilage regeneration promoter according to Item 1 or 2, in which the component (B) is contained in a total amount of 0.001 to 6 parts by weight with respect to 1 part by weight of the compone