US-20260124267-A1 - COMPOSITIONS AND METHODS FOR IMPROVING BENEFIT OF AN EXERCISE

Abstract

The present invention provides methods for improving a benefit of an exercise experienced by a subject, comprising administration to the subject a composition comprising an effective amount of Grains of Paradise, analog or derivative thereof.

Inventors

• Dawei Jin
• Kylin Liao
• Shawn Wells

Assignees

• NANJING NUTRABUILDING BIO-TECH CO., LTD.

Dates

Publication Date

20260507

Application Date

20251121

Priority Date

20230524

Claims (12)

1. 1 . A method for improving a benefit of an exercise experienced by a subject or providing a subject with a benefit associated with an exercise, comprising administration to the subject a composition comprising an effective amount of Grains of Paradise, analog or derivative thereof.
2. 2 . The method of claim 1 , wherein the benefit comprises increasing energy expenditure, reducing a body fat percentage, reducing weight, lowering a blood glucose, decreasing a blood triglyceride level, decreasing a blood total cholesterol level, decreasing a blood low-density lipoprotein, decreasing a blood very low-density lipoprotein level, improving leptin resistance, and/or improving insulin resistance, and combinations thereof.
3. 3 . The method of claim 1 , wherein the benefit is achieved by browning of white adipose tissues or promoting activation of brown adipose tissues.
4. 4 . The method of claim 3 , wherein the browning of white adipose tissues or promoting activation of brown adipose tissues is regulated by ADRB3 or β-AR.
5. 5 . The method of claim 1 , wherein the benefit of the exercise is improved with administration of the composition relative to the same exercise regimen without administration of the composition.
6. 6 . The method of claim 1 , wherein the composition is administrated in an amount ranging from 2mg/day-2000 mg/day.
7. 7 . The method of claim 1 , wherein the composition is administrated in a form of aqueous solution, aqueous suspension, capsule, drop, granule, liquid, powder, syrup, tablet, functionalized food, beverage, toothpaste, or sublingual articles.
8. 8 . The method of claim 1 , wherein the composition is in an ingestible composition, wherein the ingestible composition is selected from the group consisting of a bioceutical composition, a dietary supplement, a medicated feed, a nutraceutical composition.
9. 9 . The method of claim 1 , wherein the composition is prepared in a form of nutritional, or drinking, for use in a food, drink, nutritional products.
10. 10 . The method of claim 1 , wherein the composition is administered to the subject prior to, during or after exercise or workout.
11. 11 . The method of claim 1 , wherein, wherein the subject is human.
12. 12 . The method of claim 1 , wherein, wherein the subject is healthy human.

Description

CROSS REFERENCE TO RELATED APPLICATION This application is a continuation application of International Patent Application No. PCT/CN2024/094882, filed on May 23, 2024, which claims the priority of the International Patent Application No. PCT/CN2023/095935, filed on May 24, 2023, the contents of all of which are incorporated herein by reference in their entirety. FIELD OF THE INVENTION This invention generally relates to compositions and methods for improving a benefit of an exercise experienced by a subject, comprising administration to the subject a composition comprising an effective amount of Grains of Paradise, analog or derivative thereof. BACKGROUND OF THE INVENTION Metabolic dysfunction (like obese, etc) is an important risk factor for life threatening diseases that can target cardiovascular, metabolic and hepatic systems. Nowadays, the prevalence of metabolic dysfunction is rapidly increasing in developed and developing countries, leading to increased morbidity and mortality due to type 2 diabetes mellitus, non-alcoholic fatty liver disease, and cardiovascular disease (Abdelaal, M., C. W. le Roux, and N. G. Docherty, Morbidity and mortality associated with obesity. Annals of translational medicine, 2017. 5(7): p. 161.). Obesity and type 2 diabetes present a serious health concern globally. An imbalance in energy intake and expenditure results in weight gain and obesity. Mammals possess two specialized types of adipose tissues that serve opposite functions, white and brown adipose tissues (WAT and BAT for short respectively). Excess weight is stored in the form of lipids in white adipose tissue (WAT). In addition to these fat-storing cells, brown adipocytes also exist which can transform energy into heat, a process known as thermogenesis. Activation of thermogenesis by brown adipose tissue (BAT) can substantially contribute to weight loss and glucose metabolism. Grains of Paradise (Aframomum melegueta, GP)—also known as alligator pepper or Guinea pepper-is an ancient spice from the ginger family (Zingiberaceae). Native to West Africa, its seeds, with their ginger-type bite, have traditionally been used to flavor foods (as a replacement for pepper), and more recently, as a flavoring in craft beer. It also historically been used in traditional African medicine for a wide range of ethnobotanical applications, such as treating stomachache, diarrhea and snake bites. Additionally, there are reported studies on antiulcer, cytoprotective and antimicrobial activities as well as sexual performance enhancing effects of Grains of Paradise. In this invention, we found a unique composition including Grains of Paradise that could improve a benefit of an exercise regimen and promote the “browning” of white adipose tissue which could enhance weight loss. SUMMARY OF THE INVENTION This summary is provided to introduce a selection of concepts in a simplified form that is further described below in the Detailed Description. This summary is not intended to identify key features or essential features of the claimed subject matter, nor is it intended to be used to limit the scope of the claimed subject matter. One aspect of this invention relates to a method for improving a benefit of an exercise experienced by a subject, comprising administration to the subject a composition comprising an effective amount of Grains of Paradise, analog or derivative thereof. In some embodiments, the benefit comprises increasing energy expenditure, reducing a body fat percentage, reducing weight, lowering a blood glucose, decreasing a blood triglyceride level, decreasing a blood total cholesterol level, decreasing a blood low-density lipoprotein, decreasing a blood very low-density lipoprotein level, improving leptin resistance, and/or improving insulin resistance, and combinations thereof. In some embodiments, the benefit is achieved by browning of white adipose tissues or promoting activation of brown adipose tissues. In some embodiments, the browning of white adipose tissues or promoting activation of brown adipose tissues is regulated by ADRB3 or β-AR. In some embodiments, the benefit of the exercise is improved with administration of the composition relative to the same exercise regimen without administration of the composition. In some embodiments, the subject is engaged in an exercise regimen. In some embodiments, the composition is administered to the subject prior to, during or after exercise or workout. In some embodiments, the subject is human. In some embodiments, the subject is healthy human. In some embodiments, the body weight was decreased about more than 10% with administration of GP combined with exercise relative to the same exercise without administration of GP. The TC was decreased about more than 30% or 40% with administration of GP combined with exercise relative to the same exercise without administration of GP. The food intake was reduced with administration of GP combined with exercise relative to the same exercise