US-20260124472-A1 - TREATMENT DEVICE

US20260124472A1US 20260124472 A1US20260124472 A1US 20260124472A1US-20260124472-A1

Abstract

This invention relates to a treatment device, the use of a treatment device, and the manufacture of a treatment device, particularly in the treatment of brain disorders.

Inventors

John Noble James REYNOLDS
Paul David Harris
Stephen John Sowerby

Assignees

NEUMIC THERAPEUTICS LIMITED

Dates

Publication Date: 20260507
Application Date: 20221027

Claims (16)

1 . A treatment device configured to be worn on a head, the treatment device comprising: a frame configured to be worn on a head, and a plurality of emitters supported by the frame, the plurality of emitters configured to deliver ultrasonic radiation to a volume within the head; wherein the plurality of emitters is configured to activate a medicament cause release of a medicament, activate microbubbles, or for neuromodulation within the volume irradiated by the emitters.
2 . The treatment device of claim 1 , wherein the treatment device further comprises a plurality of second emitters configured to deliver a modality of magnetic radiation to the volume within the head.
3 . The treatment device of claim 1 , wherein the treatment device further comprises a plurality of third emitters configured to deliver a modality of electromagnetic radiation to the volume within the head.
4 . The treatment device of claim 1 , wherein the treatment device further comprises at least one detector selected from an ultrasonic detector, a magnetic detector or an electromagnetic detector configured to detect at least one modality of signals emanating from the head.
5 . The treatment device of claim 4 , wherein said at least one detector is integrated with an emitter.
6 . The treatment device of claim 4 , wherein said detector is configured to monitor drug release within the volume within the head.
7 . The treatment device of claim 6 , wherein the device further comprises a control system configured to measure the progression of a given treatment.
8 . The treatment device of claim 7 , wherein the control system provides feedback to at least one emitter.
9 . The treatment device of claim 8 , wherein the feedback is used to enable or disable one or more emitters.
10 . The treatment device of claim 1 , wherein the one or more emitters are enabled or disabled on the basis of their modality of radiation.
11 . The treatment device of claim 8 , wherein the feedback is used to automatically turn off one or more emitters when a sufficient dose of radiation has been administered.
12 . The treatment device of claim 8 , wherein the feedback is used to adjust the position and/or orientation of one or more emitters with respect to the volume and/or the frame of the treatment device.
13 . The treatment device of claim 1 , wherein the orientation and/or position of at least one emitter can be adjusted with respect to the frame.
14 . The treatment device of claim 1 , wherein the treatment device is a portable device.
15 . The treatment device of claim 14 , wherein the treatment device is untethered.
16 - 66 . (canceled)

Description

FIELD This invention relates to a treatment device, the use of a treatment device, and the manufacture of a treatment device, particularly for the treatment of brain disorders. BACKGROUND Treatment of the mammalian brain for disorders, diseases, injuries, and research is complicated by the complexity of the brain, the protection of the bones of the skull, and the selective permeability of the sieve-like tissue layer called the blood brain barrier (BBB) which encircles each blood vessel and separates the contents within the blood vessels from the neurons of the brain. Drugs introduced into the blood stream to treat the brain are systemic to the body's whole circulatory system and, when entering the blood vessels of the brain, may pass through the BBB and distribute throughout the whole brain, with little control of the location or timing of their activity. The systemic administration of drugs intended to target specific regions of the brain may cause detrimental side-effects on non-target areas of the brain and of the body. Technologies have been developed to deliver types of radiation to volumes inside the skull to ameliorate at least some of these problems. To date, these devices are typically applied to the head by large instruments in which participants are held immobile. The individual to receive the radiation is mechanically conveyed into the region of the instrument where the radiation is emitted. This approach has the disadvantage that such instruments are large, expensive, located in clinics, and are under high demand, meaning long waiting times between consecutive applications. Treatments are imposing for the participants and may not be practically able to apply continuous or semi continuous or on-demand signals to specific volumes of the brain over extended periods of time. Furthermore, instruments that deliver radiation to specific volumes of the brain often require a stereotactic frame to be surgically installed on the head of the participant to immobilize the head during the delivery of radiation. This can be uncomfortable and undesirable for the participant, introduces surgical risks, and adds further costs. There is a need for a treatment device capable of delivering ultrasound pressure and/or photonic illumination and/or magnetic fields to specific volumes inside the skull that is without the disadvantages of large instruments, implants, or indwellings, which can provide continuous use or semi-continuous or on-demand use, is able to be conveniently reconfigured to alternative volumes inside the skull, is widely available, is conveniently maintained, and is comparatively inexpensive. SUMMARY According to one example there is provided a treatment device that can be configured to be worn on a head and can comprise a frame configured to be worn on a head, and a plurality of emitters supported by the frame, the plurality of emitters configured to deliver a first modality of radiation to a volume within the head; wherein the plurality of emitters is configured to activate a medicament within the volume irradiated by the emitters. According to another example there is provided a treatment device that can be configured to be worn on a head and can comprise a frame configured to be worn on a head; and a plurality of emitters supported by the frame, each emitter being configured to deliver at least one modality of radiation to a volume within the head; wherein the treatment device is configured so that an orientation and/or position of at least one emitter with respect to the frame can be adjusted, and wherein the plurality of emitters is configured to deliver radiation to a common volume within the head. According to another example there is provided a method of manufacturing a customised head-wearable treatment device that can comprise imaging a head to determine a three-dimensional topology of the head; identifying at least one specified volume within the head to be irradiated by a plurality of emitters; determining a desired orientation of at least one emitter with respect to the specified volume; and manufacturing a customised frame configured to be worn on the head; wherein the customised frame is configured to support the at least one emitter such that when the customised frame is worn on the head, the at least one emitter is positioned with the desired orientation with respect to the specified volume within the head. According to another example of the invention there is provided a method to treat a brain disorder in a subject in need thereof comprising applying a treatment device as described herein to the head of said subject. It is acknowledged that the terms “comprise”, “comprises” and “comprising” may, under varying jurisdictions, be attributed with either an exclusive or an inclusive meaning. For the purpose of this specification, and unless otherwise noted, these terms are intended to have an inclusive meaning-i.e., they will be taken to mean an inclusion of the listed components which