US-20260125382-A1 - COMPOUNDS FOR INHIBITING OR DEGRADING CDK2 AND/OR CDK9 AND MEDICINAL USE THEREOF

Abstract

The present invention provides a compound of a certain chemical structure or a pharmaceutically acceptable salt thereof, exhibiting activity of inhibiting or degrading CDK2 and/or CDK9, and a method for preparing thereof. The present invention provides a composition comprising the compound or a pharmaceutically acceptable salt thereof. The present invention provides use of the compound, a salt thereof, or a composition comprising the same in inhibiting or degrading CDK2 and/or CDK9 and medicinal use of the same in preventing or treating a disease associated therewith. The present invention further provides method for preventing or treating a disease associated with CDK2 and/or CDK9, comprising administering the compound, a salt thereof, or a composition comprising the same to a subject in need of treatment.

Inventors

• Jong Yeon Hwang
• Sung Goo Park
• Jung-Ae Kim
• Ji Hoon Choi
• Hye Yeon LEE
• Yujin Lee
• Jae Du Ha
• Sung Yun Cho
• Pilho KIM
• Chi Hoon Park
• Hyun Jin Kim
• Jeong Hoon Kim
• Jin Hwa CHO
• Byoung Chul Park

Assignees

• KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
• KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Dates

Publication Date

20260507

Application Date

20230817

Priority Date

20220817

Claims (20)

1. 1 . A compound represented by Formula 1 below or a pharmaceutically acceptable salt thereof: wherein in Formula 1 above: R 1 is C 1-10 alkyl, aryl, —C 1-3 alkyl-C 6-10 aryl, 5-10 membered heteroaryl, —C 1-3 alkyl-5-10 membered heteroaryl, C 3-10 cycloalkyl, —C 1-3 alkyl-C 3-10 cycloalkyl, 3-10 membered heterocycloalkyl, or —C 1-3 alkyl-3-10 membered heterocycloalkyl, wherein the aryl, heteroaryl, cycloalkyl, or heterocycloalkyl is unsubstituted or substituted with one or more selected from the group consisting of halogen, cyano, tert-butoxycarbonyl (-Boc), amino, nitro, hydroxy, C 1-6 alkyl, halo-C 1-6 alkyl, —OR a , —C(═O)R a , —C(═O)OR a , —C(O)NR a R b , —SO 2 R a , —S(O)R a , —SO(N)R a , C 1-2 alkyl-C 6-10 aryl, and C 6-10 aryl, wherein R a and R b are identical or different and are independently hydrogen, halogen, amino, C 1-6 alkyl, halo-C 1-6 alkyl, C 6-10 aryl, 5-10 membered heteroaryl, C 3-10 cycloalkyl, or 3-10 membered heterocycloalkyl; A is a moiety functioning as an exit vector; L is a linker; and ELB is an E3 ubiquitin ligase binder.
2. 2 . The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein ELB has a structure represented by Formula 2 below: wherein in Formula 2 above: Cy is C 6-10 aryl, 5-10 membered heteroaryl, or 5-10 membered heterocycloalkyl; k is an integer selected from 0 to 2; X is N or C; R 2 is absent, hydrogen, deuterium (D), or C 1 -C 3 alkyl; and the aryl, heteroaryl, or heterocycloalkyl is unsubstituted or substituted with one or more selected from the group consisting of oxo, halogen, nitro, amino, hydroxy, carboxy, C 1-6 alkyl, and C 1-6 alkoxy.
3. 3 . The compound according to claim 2 or a pharmaceutically acceptable salt thereof, wherein Formula 2 is represented by any one of the structures below: (R 3 is hydrogen or halogen, and X 2 is CH or N).
4. 4 . The compound according to claim 2 or a pharmaceutically acceptable salt thereof, wherein Formula 2 is represented by any one of the structures below:
5. 5 . The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein the R 1 is C 1-6 alkyl, —C 1-3 alkyl-phenyl, phenyl, —C 1-3 alkyl-pyridyl, or pyridyl, wherein the phenyl or pyridyl is unsubstituted or substituted with one or more substituents selected from the group consisting of C 1-3 alkyl, halogen, cyano, and halo-C 1-3 alkyl.
6. 6 . The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein the R 1 is represented by any one of the structures below:
7. 7 . The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein the A has a structure represented by Formula 3 below: wherein in Formula 3 above: Cy 1 is C 6-10 aryl or 5-10 membered heteroaryl, unsubstituted or substituted with C 1-3 alkyl; Cy 2 is 3-10 membered heterocycloalkyl; and l is an integer selected from 0 to 4, and m, n, and p are independently 0 or 1, wherein all of l, m, n, and p are not simultaneously 0.
8. 8 . The compound according to claim 7 or a pharmaceutically acceptable salt thereof, wherein the A is represented by any one of the structures below:
9. 9 . The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein the linker is -L1-L2-; L2 is a direct linker, and L1 is wherein: q, t, v, x, and z are independently 0 or 1; r, s, u, and y are independently an integer selected from 0 to 6; Ch is C 1-4 alkenyl or C 1-4 alkynyl; and Cy 3 and Cy 4 are independently absent, 3-10 membered heterocycloalkyl, or C 3-10 cycloalkyl.
10. 10 . The compound according to claim 9 or a pharmaceutically acceptable salt thereof, wherein L 1 is represented by any one of the structures below:
11. 11 . The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein the compound is: N-((1s,3s)-3-(6-((1-(6-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)acetamido)hexanoyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(6-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamido)hexanoyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(6-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetamido)hexanoyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(6-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)hexanoyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)hexanoyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexanoyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetamido)ethoxy)ethoxy)acetyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)ethoxy)ethoxy)acetyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)acetamido)ethoxy)ethoxy)acetyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamido)ethoxy)ethoxy)acetyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)ethoxy)ethoxy)acetyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)acetyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(6-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)acetamido)hexyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(6-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamido)hexyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(6-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetamido)hexyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(6-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)hexyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)hexyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)acetamido)ethoxy)ethoxy)ethyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamido)ethoxy)ethoxy)ethyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetamido)ethoxy)ethoxy)ethyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)ethoxy)ethoxy)ethyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)ethoxy)ethoxy)ethyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)piperidin-4-yl)methyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperidin-4-yl)methyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-((1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetyl)piperidin-4-yl)methyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-((1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetyl)piperidin-4-yl)methyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperidin-4-yl)methyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(2-(1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetyl)piperidin-4-yl)ethyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(2-(1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetyl)piperidin-4-yl)ethyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(2-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)piperidin-4-yl)ethyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(2-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperidin-4-yl)ethyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(2-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)ethyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(2-(1-(2-(2,4-dioxocyclohexyl)-1,3-dioxoisoindolin-4-yl)piperidin-4-yl)ethyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(3-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)piperazin-1-yl)propyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(3-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperazin-1-yl)propyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(3-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetyl)piperazin-1-yl)propyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(3-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetyl)piperazin-1-yl)propyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(3-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)propyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(3-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperazin-1-yl)propyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(2-((1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetyl)piperidin-4-yl)oxy)ethyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(2-((1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetyl)piperidin-4-yl)oxy)ethyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(2-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)piperidin-4-yl)oxy)ethyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(2-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperidin-4-yl)oxy)ethyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(2-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)oxy)ethyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(2-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperidin-4-yl)oxy)ethyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(2-(1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetyl)piperidin-4-yl)acetyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(2-(1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetyl)piperidin-4-yl)acetyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(2-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)piperidin-4-yl)acetyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(2-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperidin-4-yl)acetyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(2-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)acetyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((1-(2-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperidin-4-yl)acetyl)piperidin-4-yl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-(((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-(((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-(((1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-(((1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-(((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-(((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1r,3r)-3-(6-(((1-(6-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)acetamido)hexanoyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1r,3r)-3-(6-(((1-(6-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamido)hexanoyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1r,3r)-3-(6-(((1-(6-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetamido)hexanoyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1r,3r)-3-(6-(((1-(6-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)hexanoyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1r,3r)-3-(6-(((1-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)hexanoyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1r,3r)-3-(6-(((1-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexanoyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-(((1-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetamido)ethoxy)ethoxy)acetyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-(((1-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)ethoxy)ethoxy)acetyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-(((1-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)acetamido)ethoxy)ethoxy)acetyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-(((1-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamido)ethoxy)ethoxy)acetyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-(((1-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)acetyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1r,3r)-3-(6-(((1-((1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetyl)piperidin-4-yl)methyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1r,3r)-3-(6-(((1-((1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetyl)piperidin-4-yl)methyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1r,3r)-3-(6-(((1-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)piperidin-4-yl)methyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1r,3r)-3-(6-(((1-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperidin-4-yl)methyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1r,3r)-3-(6-(((1-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1r,3r)-3-(6-(((1-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperidin-4-yl)methyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1r,3r)-3-(6-(((1-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)ethoxy)ethoxy)ethyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1r,3r)-3-(6-(((1-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamido)ethoxy)ethoxy)ethyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1r,3r)-3-(6-(((1-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetamido)ethoxy)ethoxy)ethyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1r,3r)-3-(6-(((1-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)acetamido)ethoxy)ethoxy)ethyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-((1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-((1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((3-((1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetyl)piperidin-4-yl)methoxy)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((3-((1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetyl)piperidin-4-yl)methoxy)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((3-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)piperidin-4-yl)methoxy)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((3-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperidin-4-yl)methoxy)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((3-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methoxy)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((3-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperidin-4-yl)methoxy)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((3-(3-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetyl)piperazin-1-yl)propoxy)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((3-(3-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetyl)piperazin-1-yl)propoxy)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((3-(3-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)piperazin-1-yl)propoxy)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((3-(3-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperazin-1-yl)propoxy)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((3-(3-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)propoxy)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((3-(3-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperazin-1-yl)propoxy)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-((1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetyl)piperidin-4-yl)methoxy)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-((1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetyl)piperidin-4-yl)methoxy)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)piperidin-4-yl)methoxy)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperidin-4-yl)methoxy)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methoxy)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperidin-4-yl)methoxy)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(3-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetyl)piperazin-1-yl)propoxy)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(3-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetyl)piperazin-1-yl)propoxy)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(3-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)piperazin-1-yl)propoxy)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(3-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperazin-1-yl)propoxy)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(3-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)propoxy)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(3-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperazin-1-yl)propoxy)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((2-(1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetyl)piperidin-4-yl)ethyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((2-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperidin-4-yl)ethyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((2-(1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetyl)piperidin-4-yl)ethyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((2-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)piperidin-4-yl)ethyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((2-(1-((1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetyl)piperidin-4-yl)methyl)piperidin-4-yl)ethyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((2-(1-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperidin-4-yl)methyl)piperidin-4-yl)ethyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((2-(1-((1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetyl)piperidin-4-yl)methyl)piperidin-4-yl)ethyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((2-(1-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)piperidin-4-yl)methyl)piperidin-4-yl)ethyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((3-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperazin-1-yl)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((3-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((3-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetyl)piperazin-1-yl)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((3-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetyl)piperazin-1-yl)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((3-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperazin-1-yl)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((3-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)piperazin-1-yl)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((3-(4-((1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetyl)piperidin-4-yl)methyl)piperazin-1-yl)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((3-(4-((1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetyl)piperidin-4-yl)methyl)piperazin-1-yl)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((3-(4-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperidin-4-yl)methyl)piperazin-1-yl)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((3-(4-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)piperidin-4-yl)methyl)piperazin-1-yl)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((3-(4-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperidin-4-yl)methyl)piperazin-1-yl)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((3-(4-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)piperazin-1-yl)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1r,3r)-3-(6-((3-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetyl)piperazin-1-yl)propyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1r,3r)-3-(6-((3-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperazin-1-yl)propyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1r,3r)-3-(6-((3-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetyl)piperazin-1-yl)propyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1r,3r)-3-(6-((3-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)piperazin-1-yl)propyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1r,3r)-3-(6-((3-(4-((1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetyl)piperidin-4-yl)methyl)piperazin-1-yl)propyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1r,3r)-3-(6-((3-(4-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperidin-4-yl)methyl)piperazin-1-yl)propyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1r,3r)-3-(6-((3-(4-((1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetyl)piperidin-4-yl)methyl)piperazin-1-yl)propyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1r,3r)-3-(6-((3-(4-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)piperidin-4-yl)methyl)piperazin-1-yl)propyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperazin-1-yl)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperazin-1-yl)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)piperazin-1-yl)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperidin-4-yl)methyl)piperazin-1-yl)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)piperazin-1-yl)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperidin-4-yl)methyl)piperazin-1-yl)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)piperidin-4-yl)methyl)piperazin-1-yl)benzyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-(((1-((1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetyl)piperidin-4-yl)methyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)acetamide, N-((1s,3s)-3-(6-(((1-((1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetyl)piperidin-4-yl)methyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)acetamide, N-((1s,3s)-3-(6-(((1-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)piperidin-4-yl)methyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)acetamide, N-((1s,3s)-3-(6-(((1-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperidin-4-yl)methyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)acetamide, N-((1s,3s)-3-(6-(((1-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)acetamide, N-((1s,3s)-3-(6-(((1-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperidin-4-yl)methyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)acetamide, N-((1s,3s)-3-(6-((4-(4-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperidin-4-yl)methyl)piperazin-1-yl)benzyl)amino)-9H-purin-9-yl)cyclobutyl)acetamide, N-((1s,3s)-3-(6-((4-(4-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)piperidin-4-yl)methyl)piperazin-1-yl)benzyl)amino)-9H-purin-9-yl)cyclobutyl)acetamide, 2,6-dichloro-N-((1s,3s)-3-(6-((4-(4-((1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, 2,6-dichloro-N-((1s,3s)-3-(6-((4-(4-((1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, 2,6-dichloro-N-((1s,3s)-3-(6-((4-(4-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, 2,6-dichloro-N-((1s,3s)-3-(6-((4-(4-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, 2,6-dichloro-N-((1s,3s)-3-(6-((4-(4-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, 2,6-dichloro-N-((1s,3s)-3-(6-((4-(4-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, 2,6-dichloro-N-((1s,3s)-3-(6-(((1-((1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetyl)piperidin-4-yl)methyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, 2,6-dichloro-N-((1s,3s)-3-(6-(((1-((1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetyl)piperidin-4-yl)methyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, 2,6-dichloro-N-((1s,3s)-3-(6-(((1-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperidin-4-yl)methyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, 2,6-dichloro-N-((1s,3s)-3-(6-(((1-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)piperidin-4-yl)methyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, 2,6-dichloro-N-((1s,3s)-3-(6-(((1-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperidin-4-yl)methyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, 2,6-dichloro-N-((1s,3s)-3-(6-(((1-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, N-((1s,3s)-3-(6-((4-(4-((1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-((1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-(((1-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperidin-4-yl)methyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-(((1-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-(((1-((1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetyl)piperidin-4-yl)methyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-(((1-((1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetyl)piperidin-4-yl)methyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-(((1-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperidin-4-yl)methyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-(((1-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)piperidin-4-yl)methyl)piperidin-4-yl)methyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-((1-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-4-methoxybenzoyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-((1-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)benzofuran-6-carbonyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-((1-(2-(3-((1-(2,6-dioxopiperidin-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)amino)phenyl)acetyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-((1-(1-(1-(2,6-dioxopiperidin-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)piperidin-4-carbonyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(7-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-4-methoxybenzoyl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(7-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)benzofuran-6-carbonyl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(7-(2-(3-((1-(2,6-dioxopiperidin-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)amino)phenyl)acetyl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(7-(1-(1-(2,6-dioxopiperidin-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)piperidin-4-carbonyl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(2-(1-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-4-methoxybenzoyl)piperidin-4-yl)acetyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(2-(1-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)benzofuran-6-carbonyl)piperidin-4-yl)acetyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(2-(1-(2-(3-((1-(2,6-dioxopiperidin-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)amino)phenyl)acetyl)piperidin-4-yl)acetyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(2-(1-(1-(1-(2,6-dioxopiperidin-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)piperidin-4-carbonyl)piperidin-4-yl)acetyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, 3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-4-methoxy-N-(((1r,4r)-4-((4-(4-((9-((1s,3s)-3-(2-phenylacetamido)cyclobutyl)-9H-purin-6-yl)amino)phenyl)piperazin-1-yl)methyl)cyclohexyl)methyl)benzamide, 3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-N-(((1r,4r)-4-((4-(4-((9-((1s,3s)-3-(2-phenylacetamido)cyclobutyl)-9H-purin-6-yl)amino)phenyl)piperazin-1-yl)methyl)cyclohexyl)methyl)benzofuran-6-carboxamide, 2-(3-((1-(2,6-dioxopiperidin-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)amino)phenyl)-N-(((1r,4r)-4-((4-(4-((9-((1s,3s)-3-(2-phenylacetamido)cyclobutyl)-9H-purin-6-yl)amino)phenyl)piperazin-1-yl)methyl)cyclohexyl)methyl)acetamide, 1-(1-(2,6-dioxopiperidin-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)-N-(((1r,4r)-4-((4-(4-((9-((1s,3s)-3-(2-phenylacetamido)cyclobutyl)-9H-purin-6-yl)amino)phenyl)piperazin-1-yl)methyl)cyclohexyl)methyl)piperidin-4-carboxamide, N-((1s,3s)-3-(6-((4-(4-((1-(2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(2-(1-(2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)piperidin-4-yl)acetyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(7-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(7-(2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(7-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetyl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(7-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(7-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetyl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(7-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(7-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(2-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperidin-4-yl)acetyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(2-(1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetyl)piperidin-4-yl)acetyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(2-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)piperidin-4-yl)acetyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(2-(1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetyl)piperidin-4-yl)acetyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(2-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperidin-4-yl)acetyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(2-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)acetyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, 2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)-N-(((1r,4r)-4-((4-(4-((9-((1s,3s)-3-(2-phenylacetamido)cyclobutyl)-9H-purin-6-yl)amino)phenyl)piperazin-1-yl)methyl)cyclohexyl)methyl)acetamide, 2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-N-(((1r,4r)-4-((4-(4-((9-((1s,3s)-3-(2-phenylacetamido)cyclobutyl)-9H-purin-6-yl)amino)phenyl)piperazin-1-yl)methyl)cyclohexyl)methyl)acetamide, 2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-N-(((1r,4r)-4-((4-(4-((9-((1s,3s)-3-(2-phenylacetamido)cyclobutyl)-9H-purin-6-yl)amino)phenyl)piperazin-1-yl)methyl)cyclohexyl)methyl)acetamide, 2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)-N-(((1r,4r)-4-((4-(4-((9-((1s,3s)-3-(2-phenylacetamido)cyclobutyl)-9H-purin-6-yl)amino)phenyl)piperazin-1-yl)methyl)cyclohexyl)methyl)acetamide, 2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)-N-(((1r,4r)-4-((4-(4-((9-((1s,3s)-3-(2-phenylacetamido)cyclobutyl)-9H-purin-6-yl)amino)phenyl)piperazin-1-yl)methyl)cyclohexyl)methyl)acetamide, N-((1s,3s)-3-(6-((4-(4-(((1r,4r)-4-(((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)methyl)cyclohexyl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, 2-(3-(2,6-dioxopiperidin-3-yl)phenoxy)-N-(((1r,4r)-4-((4-(4-((9-((1s,3s)-3-(2-phenylacetamido)cyclobutyl)-9H-purin-6-yl)amino)phenyl)piperazin-1-yl)methyl)cyclohexyl)methyl)acetamide, N-((1s,3s)-3-(6-((3-(4-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperidin-4-yl)methyl)piperazin-1-yl)propyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-((1-(2-(3-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(7-(2-(3-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(2-(1-(2-(3-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)piperidin-4-yl)acetyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((3-(4-((1-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-4-methoxybenzoyl)piperidin-4-yl)methyl)piperazin-1-yl)propyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((3-(4-((1-(2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)piperidin-4-yl)methyl)piperazin-1-yl)propyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((3-(4-((1-(2-(3-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)piperidin-4-yl)methyl)piperazin-1-yl)propyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-(3-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperazin-1-yl)propyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(3-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetyl)piperazin-1-yl)propyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(3-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)piperazin-1-yl)propyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(3-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetyl)piperazin-1-yl)propyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(3-(4-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-4-methoxybenzoyl)piperazin-1-yl)propyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(3-(4-(2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)piperazin-1-yl)propyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(3-(4-(2-(3-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)piperazin-1-yl)propyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(3-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperazin-1-yl)propyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(3-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)propyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(3-(4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)propyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-((1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(2-(1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)acetyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(((1r,4r)-4-(((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)amino)methyl)cyclohexyl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(7-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(2-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperidin-4-yl)oxy)ethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(2-((1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetyl)piperidin-4-yl)oxy)ethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(2-((1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetyl)piperidin-4-yl)oxy)ethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(2-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)piperidin-4-yl)oxy)ethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(2-((1-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-4-methoxybenzoyl)piperidin-4-yl)oxy)ethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(2-((1-(2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)piperidin-4-yl)oxy)ethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(2-((1-(2-(3-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)piperidin-4-yl)oxy)ethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(2-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)oxy)ethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(3-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperidin-4-yl)propyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(3-(1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetyl)piperidin-4-yl)propyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(3-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)piperidin-4-yl)propyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(3-(1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetyl)piperidin-4-yl)propyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(3-(1-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-4-methoxybenzoyl)piperidin-4-yl)propyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(3-(1-(2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)piperidin-4-yl)propyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(3-(1-(2-(3-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)piperidin-4-yl)propyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(2-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperidin-4-yl)oxy)ethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(3-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperidin-4-yl)propyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(3-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)propyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)-6-azaspiro[3.4]octan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(6-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetyl)-6-azaspiro[3.4]octan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)-6-azaspiro[3.4]octan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(6-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetyl)-6-azaspiro[3.4]octan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(6-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-4-methoxybenzoyl)-6-azaspiro[3.4]octan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(6-(2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)-6-azaspiro[3.4]octan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(6-(2-(3-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)-6-azaspiro[3.4]octan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(7-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)azetidin-3-yl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(7-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)azetidin-3-yl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(7-(1-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-4-methoxybenzoyl)azetidin-3-yl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(7-(1-(2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)azetidin-3-yl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(7-(1-(2-(3-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)azetidin-3-yl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(7-((1-(2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)azetidin-3-yl)methyl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(7-((1-(2-(3-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)azetidin-3-yl)methyl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(7-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)azetidin-3-yl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(7-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)azetidin-3-yl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(7-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)azetidin-3-yl)methyl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(7-((1-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-4-methoxybenzoyl)azetidin-3-yl)methyl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(1-((1-(2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)piperidin-4-yl)methyl)piperidin-4-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(1-((1-(2-(3-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)piperidin-4-yl)methyl)piperidin-4-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(1-((1-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-4-methoxybenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(1-(7-(2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)-7-azaspiro[3.5]nonan-2-yl)piperidin-4-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(1-(7-(2-(3-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)-7-azaspiro[3.5]nonan-2-yl)piperidin-4-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(1-(7-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-4-methoxybenzoyl)-7-azaspiro[3.5]nonan-2-yl)piperidin-4-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(1-((1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetyl)piperidin-4-yl)methyl)piperidin-4-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(1-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperidin-4-yl)methyl)piperidin-4-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(1-((1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetyl)piperidin-4-yl)methyl)piperidin-4-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(1-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)piperidin-4-yl)methyl)piperidin-4-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(1-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperidin-4-yl)methyl)piperidin-4-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(1-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)piperidin-4-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(1-(7-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetyl)-7-azaspiro[3.5]nonan-2-yl)piperidin-4-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(1-(7-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)-7-azaspiro[3.5]nonan-2-yl)piperidin-4-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(1-(7-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetyl)-7-azaspiro[3.5]nonan-2-yl)piperidin-4-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(1-(7-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)-7-azaspiro[3.5]nonan-2-yl)piperidin-4-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(1-(7-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-7-azaspiro[3.5]nonan-2-yl)piperidin-4-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(1-(7-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-7-azaspiro[3.5]nonan-2-yl)piperidin-4-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, 2,6-dichloro-N-((1s,3s)-3-(6-((4-(4-((1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, 2,6-dichloro-N-((1s,3s)-3-(6-((4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)methyl)piperidin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, 2,6-dichloro-N-((1s,3s)-3-(6-((4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)methyl)piperidin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, N-((1s,3s)-3-(6-((2-(1-((1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)piperidin-4-yl)ethyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((2-(1-((1-(3-(2,6-dioxopiperidin-3-yl)-4-oxo-3,4-dihydrobenzo[d][1,2,3]triazin-5-yl)piperidin-4-yl)methyl)piperidin-4-yl)ethyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((2-(1-((1-(3-(2,6-dioxopiperidin-3-yl)-4-oxo-3,4-dihydrobenzo[d][1,2,3]triazin-6-yl)piperidin-4-yl)methyl)piperidin-4-yl)ethyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, 2,6-dichloro-N-((1s,3s)-3-(6-((4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperazin-1-yl)methyl)piperidin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, N-((1s,3s)-3-(6-((2-(1-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperidin-4-yl)methyl)piperidin-4-yl)ethyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-((1-(3-(2,6-dioxopiperidin-3-yl)-4-oxo-3,4-dihydrobenzo[d][1,2,3]triazin-6-yl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((2-(1-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)piperidin-4-yl)ethyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((2-(1-((1-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)azetidin-3-carbonyl)piperidin-4-yl)methyl)piperidin-4-yl)ethyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((2-(1-((1-(3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)propanoyl)piperidin-4-yl)methyl)piperidin-4-yl)ethyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, 2,6-dichloro-N-((1s,3s)-3-(6-((4-(4-((4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperazin-1-yl)methyl)piperidin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, 2,6-dichloro-N-((1s,3s)-3-(6-((4-(4-((4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)piperazin-1-yl)methyl)piperidin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, N-((1s,3s)-3-(6-((4-(4-((1-(3-(2,6-dioxopiperidin-3-yl)-4-oxo-3,4-dihydrobenzo[d][1,2,3]triazin-5-yl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(7-(3-(2,6-dioxopiperidin-3-yl)-4-oxo-3,4-dihydrobenzo[d][1,2,3]triazin-6-yl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, 2,6-dichloro-N-((1s,3s)-3-(6-((4-(4-(7-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, 2,6-dichloro-N-((1s,3s)-3-(6-((4-(4-(7-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, 2,6-dichloro-N-((1s,3s)-3-(6-((4-(4-(7-(3-(2,6-dioxopiperidin-3-yl)-4-oxo-3,4-dihydrobenzo[d][1,2,3]triazin-6-yl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, 2,6-dichloro-N-((1s,3s)-3-(6-((4-(4-(7-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycyl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, N-((1s,3s)-3-(6-((4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)methyl)piperidin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-((4-(3-(2,6-dioxopiperidin-3-yl)-4-oxo-3,4-dihydrobenzo[d][1,2,3]triazin-6-yl)piperazin-1-yl)methyl)piperidin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-((4-(3-(2,6-dioxopiperidin-3-yl)-4-oxo-3,4-dihydrobenzo[d][1,2,3]triazin-5-yl)piperazin-1-yl)methyl)piperidin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-((4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperazin-1-yl)methyl)piperidin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(2-(1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)ethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(2-(1-(3-(2,6-dioxopiperidin-3-yl)-4-oxo-3,4-dihydrobenzo[d][1,2,3]triazin-6-yl)piperidin-4-yl)ethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, 2,6-dichloro-N-((1s,3s)-3-(6-((4-(4-((4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)acetyl)piperazin-1-yl)methyl)piperidin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, N-((1s,3s)-3-(6-((4-(4-((4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetyl)piperazin-1-yl)methyl)piperidin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(2-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)ethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(2-(1-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)azetidin-3-carbonyl)piperidin-4-yl)ethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-((1-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)azetidin-3-carbonyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-((1-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-((4-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)azetidin-3-carbonyl)piperazin-1-yl)methyl)piperidin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(1-(3-(2,6-dioxopiperidin-3-yl)-4-oxo-3,4-dihydrobenzo[d][1,2,3]triazin-6-yl)piperidin-4-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(2-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)-7-azaspiro[3.5]nonan-7-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(2-(4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)-7-azaspiro[3.5]nonan-7-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(2-(4-(3-(2,6-dioxopiperidin-3-yl)-4-oxo-3,4-dihydrobenzo[d][1,2,3]triazin-6-yl)piperazin-1-yl)-7-azaspiro[3.5]nonan-7-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(2-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)ethyl)piperidin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(2-(4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)ethyl)piperidin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(2-(4-(3-(2,6-dioxopiperidin-3-yl)-4-oxo-3,4-dihydrobenzo[d][1,2,3]triazin-6-yl)piperazin-1-yl)ethyl)piperidin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)methyl)piperidin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(1-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)azetidin-3-carbonyl)piperidin-4-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(1-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)piperidin-4-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)azetidin-3-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)azetidin-3-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(1-(3-(2,6-dioxopiperidin-3-yl)-4-oxo-3,4-dihydrobenzo[d][1,2,3]triazin-6-yl)azetidin-3-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(3-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)propyl)piperidin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(3-(4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)propyl)piperidin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(3-(4-(3-(2,6-dioxopiperidin-3-yl)-4-oxo-3,4-dihydrobenzo[d][1,2,3]triazin-6-yl)piperazin-1-yl)propyl)piperidin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(1-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)azetidin-3-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(3-(1-(3-(2,6-dioxopiperidin-3-yl)-4-oxo-3,4-dihydrobenzo[d][1,2,3]triazin-6-yl)piperidin-4-yl)propyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(7-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)azetidin-3-carbonyl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(7-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(3-(1-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)piperidin-4-yl)propyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((2-(1-((1-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)piperidin-4-yl)methyl)piperidin-4-yl)ethyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)piperidin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(4-(3-(2,6-dioxopiperidin-3-yl)-4-oxo-3,4-dihydrobenzo[d][1,2,3]triazin-6-yl)piperazin-1-yl)piperidin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(3-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)azetidin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(3-(4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)azetidin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(2-(4-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)azetidin-3-carbonyl)piperazin-1-yl)-7-azaspiro[3.5]nonan-7-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(2-(4-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)piperazin-1-yl)-7-azaspiro[3.5]nonan-7-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(2-(4-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)azetidin-3-carbonyl)piperazin-1-yl)ethyl)piperidin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(2-(4-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)piperazin-1-yl)ethyl)piperidin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(4-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)azetidin-3-carbonyl)piperazin-1-yl)piperidin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(4-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)piperazin-1-yl)piperidin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(3-(4-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)azetidin-3-carbonyl)piperazin-1-yl)propyl)piperidin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(3-(4-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)piperazin-1-yl)propyl)piperidin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(3-(4-(3-(2,6-dioxopiperidin-3-yl)-4-oxo-3,4-dihydrobenzo[d][1,2,3]triazin-6-yl)piperazin-1-yl)azetidin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)piperidin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, 2,6-dichloro-N-((1s,3s)-3-(6-((4-(4-((4-(3-(2,6-dioxopiperidin-3-yl)-4-oxo-3,4-dihydrobenzo[d][1,2,3]triazin-6-yl)piperazin-1-yl)methyl)piperidin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, 2,6-dichloro-N-((1s,3s)-3-(6-((4-(4-((1-(3-(2,6-dioxopiperidin-3-yl)-4-oxo-3,4-dihydrobenzo[d][1,2,3]triazin-6-yl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, N-((1s,3s)-3-(6-((4-(4-(3-(1-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)azetidin-3-carbonyl)piperidin-4-yl)propyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(3-(4-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)azetidin-3-carbonyl)piperazin-1-yl)azetidin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((2-(1-((1-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)piperidin-4-yl)methyl)piperidin-4-yl)ethyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-(2-(1-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)azetidin-3-yl)methyl)piperidin-4-yl)ethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, 2,6-dichloro-N-((1s,3s)-3-(6-((4-(4-(7-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, N-((1s,3s)-3-(6-((4-(4-((1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-((1-(3-(2,6-dioxopiperidin-3-yl)-4-oxo-3,4-dihydrobenzo[d][1,2,3]triazin-6-yl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-((1-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-(2-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)ethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-(2-(1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)ethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-(2-(1-(3-(2,6-dioxopiperidin-3-yl)-4-oxo-3,4-dihydrobenzo[d][1,2,3]triazin-6-yl)piperidin-4-yl)ethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, 2,6-dichloro-N-((1s,3s)-3-(6-((4-(4-(7-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)azetidin-3-carbonyl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, N-((1s,3s)-3-(6-((4-(4-(7-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-(7-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-(7-(3-(2,6-dioxopiperidin-3-yl)-4-oxo-3,4-dihydrobenzo[d][1,2,3]triazin-6-yl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-(7-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)azetidin-3-carbonyl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-(2-(1-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)azetidin-3-carbonyl)piperidin-4-yl)ethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-(2-(1-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)piperidin-4-yl)ethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-fluoropicolinamide, 6-chloro-N-((1s,3s)-3-(6-((4-(4-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)picolinamide, 6-cyano-N-((1s,3s)-3-(6-((4-(4-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)picolinamide, N-((1s,3s)-3-(6-((4-(4-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-(trifluoromethyl)picolinamide, 2,6-dichloro-N-((1s,3s)-3-(6-((4-(4-((1-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)azetidin-3-carbonyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, 2,6-dichloro-N-((1s,3s)-3-(6-((4-(4-((1-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, 2,6-dichloro-N-((1s,3s)-3-(6-((2-(1-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)piperidin-4-yl)ethyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, 2,6-dichloro-N-((1s,3s)-3-(6-((2-(1-((1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)piperidin-4-yl)ethyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, 2,6-dichloro-N-((1s,3s)-3-(6-((2-(1-((1-(3-(2,6-dioxopiperidin-3-yl)-4-oxo-3,4-dihydrobenzo[d][1,2,3]triazin-6-yl)piperidin-4-yl)methyl)piperidin-4-yl)ethyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, 2,6-dichloro-N-((1s,3s)-3-(6-((2-(1-((1-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)azetidin-3-carbonyl)piperidin-4-yl)methyl)piperidin-4-yl)ethyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, 2,6-dichloro-N-((1s,3s)-3-(6-((2-(1-((1-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)piperidin-4-yl)methyl)piperidin-4-yl)ethyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, N-((1s,3s)-3-(6-((4-(4-((1-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)azetidin-3-carbonyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((2-(1-((1-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)azetidin-3-yl)methyl)piperidin-4-yl)methyl)piperidin-4-yl)ethyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-(7-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-(2-(1-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)piperidin-4-yl)ethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, 2,6-dichloro-N-((1s,3s)-3-(6-((4-(4-(2-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)ethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, 2,6-dichloro-N-((1s,3s)-3-(6-((4-(4-(2-(1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)ethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, 2,6-dichloro-N-((1s,3s)-3-(6-((4-(4-(2-(1-(3-(2,6-dioxopiperidin-3-yl)-4-oxo-3,4-dihydrobenzo[d][1,2,3]triazin-6-yl)piperidin-4-yl)ethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, N-((1s,3s)-3-(6-((4-(4-(1-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)butyl)piperidin-4-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((2-(1-((1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)piperidin-4-yl)ethyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((2-(1-((1-(3-(2,6-dioxopiperidin-3-yl)-4-oxo-3,4-dihydrobenzo[d][1,2,3]triazin-6-yl)piperidin-4-yl)methyl)piperidin-4-yl)ethyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((2-(1-((1-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)azetidin-3-carbonyl)piperidin-4-yl)methyl)piperidin-4-yl)ethyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, 2,6-dichloro-N-((1s,3s)-3-(6-((4-(4-(2-(1-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)azetidin-3-carbonyl)piperidin-4-yl)ethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, 2,6-dichloro-N-((1s,3s)-3-(6-((4-(4-(2-(1-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)piperidin-4-yl)ethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, 6-cyano-N-((1s,3s)-3-(6-((4-(4-((1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)picolinamide, N-((1s,3s)-3-(6-((4-(4-((1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-(trifluoromethyl)picolinamide, 6-chloro-N-((1s,3s)-3-(6-((4-(4-((1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)picolinamide, 6-chloro-N-((1s,3s)-3-(6-((4-(4-((1-(3-(2,6-dioxopiperidin-3-yl)-4-oxo-3,4-dihydrobenzo[d][1,2,3]triazin-6-yl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)picolinamide, 6-cyano-N-((1s,3s)-3-(6-((4-(4-((1-(3-(2,6-dioxopiperidin-3-yl)-4-oxo-3,4-dihydrobenzo[d][1,2,3]triazin-6-yl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)picolinamide, 6-chloro-N-((1s,3s)-3-(6-((4-(4-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)picolinamide, 6-cyano-N-((1s,3s)-3-(6-((4-(4-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)picolinamide, N-((1s,3s)-3-(6-((2-(1-((1-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)piperidin-4-yl)methyl)piperidin-4-yl)ethyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((2-(1-((1-(3-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)propyl)piperidin-4-yl)methyl)piperidin-4-yl)ethyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((2-(1-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)piperidin-4-yl)ethyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-((1-(3-(2,6-dioxopiperidin-3-yl)-4-oxo-3,4-dihydrobenzo[d][1,2,3]triazin-6-yl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-(trifluoromethyl)picolinamide, N-((1s,3s)-3-(6-((4-(4-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-(trifluoromethyl)picolinamide, N-((1s,3s)-3-(6-((4-(4-((1-(3-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)propyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-(trifluoromethyl)picolinamide, N-((1s,3s)-3-(6-((4-(4-((1-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)butyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-(trifluoromethyl)picolinamide, N-((1s,3s)-3-(6-((4-(4-((1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-fluoropicolinamide, N-((1s,3s)-3-(6-((4-(4-((1-(3-(2,6-dioxopiperidin-3-yl)-4-oxo-3,4-dihydrobenzo[d][1,2,3]triazin-6-yl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-fluoropicolinamide, N-((1s,3s)-3-(6-((4-(4-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-fluoropicolinamide, N-((1s,3s)-3-(6-((4-(4-((1-(3-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)propyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-fluoropicolinamide, N-((1s,3s)-3-(6-((4-(4-((1-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)butyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-fluoropicolinamide, N-((1s,3s)-3-(6-((4-(4-(2-(1-(2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)piperidin-4-yl)ethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, 2,6-dichloro-N-((1s,3s)-3-(6-((4-(4-(2-(1-(2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)piperidin-4-yl)ethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, N-((1s,3s)-3-(6-((4-(4-(7-(2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-((1-(2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-(trifluoromethyl)picolinamide, 2,6-dichloro-N-((1s,3s)-3-(6-((4-(4-((1-(2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, N-((1s,3s)-3-(6-((4-(4-(2-(1-(2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)piperidin-4-yl)ethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-(trifluoromethyl)picolinamide, N-((1s,3s)-3-(6-((4-(4-(7-(2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-(trifluoromethyl)picolinamide, 6-chloro-N-((1s,3s)-3-(6-((4-(4-((1-(2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)picolinamide, 6-cyano-N-((1s,3s)-3-(6-((4-(4-((1-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)picolinamide, 2,6-dichloro-N-((1s,3s)-3-(6-((4-(4-(7-(2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, N-((1s,3s)-3-(6-((4-(4-((1-(2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-(2-(1-(2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)piperidin-4-yl)ethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)piperazin-1-yl)-2-methylphenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-((1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)piperazin-1-yl)-2-methylphenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-((1-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)piperidin-4-yl)methyl)piperazin-1-yl)-2-methylphenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-((1-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)azetidin-3-carbonyl)piperidin-4-yl)methyl)piperazin-1-yl)-2-methylphenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-(2-(1-(1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)piperidin-4-yl)ethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((2-(1-((1-(1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)piperidin-4-yl)methyl)piperidin-4-yl)ethyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, 6-chloro-N-((1s,3s)-3-(6-((4-(4-((1-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)azetidin-3-carbonyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)picolinamide, 6-chloro-N-((1s,3s)-3-(6-((4-(4-((1-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)picolinamide, 6-chloro-N-((1s,3s)-3-(6-((4-(4-((1-(1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)picolinamide, 6-cyano-N-((1s,3s)-3-(6-((4-(4-((1-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)azetidin-3-carbonyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)picolinamide, 6-cyano-N-((1s,3s)-3-(6-((4-(4-((1-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)picolinamide, N-((1s,3s)-3-(6-((4-(4-((1-(1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(2-(1-(1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)piperidin-4-yl)ethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(3-(1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)propyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(3-(1-(1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)piperidin-4-yl)propyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((4-(4-(7-(1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, N-((1s,3s)-3-(6-((2-(1-((1-(1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)piperidin-4-yl)methyl)piperidin-4-yl)ethyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide, 2,6-dichloro-N-((1s,3s)-3-(6-((4-(4-((1-(1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, 2,6-dichloro-N-((1s,3s)-3-(6-((4-(4-(2-(1-(1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)piperidin-4-yl)ethyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, 2,6-dichloro-N-((1s,3s)-3-(6-((4-(4-(7-(1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, N-((1s,3s)-3-(6-((4-(4-(7-(1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-((1-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)azetidin-3-carbonyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-fluoropicolinamide, N-((1s,3s)-3-(6-((4-(4-((1-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-fluoropicolinamide, N-((1s,3s)-3-(6-((4-(4-((1-(1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-fluoropicolinamide, N-((1s,3s)-3-(6-((4-(4-((1-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)azetidin-3-carbonyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-(trifluoromethyl)picolinamide, N-((1s,3s)-3-(6-((4-(4-((1-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-(trifluoromethyl)picolinamide, N-((1s,3s)-3-(6-((4-(4-((1-(1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-(trifluoromethyl)picolinamide, 6-cyano-N-((1s,3s)-3-(6-((4-(4-((1-(1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)picolinamide, 2,6-dichloro-N-((1s,3s)-3-(6-((4-(4-((4-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)azetidin-3-carbonyl)piperazin-1-yl)methyl)piperidin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, 2,6-dichloro-N-((1s,3s)-3-(6-((4-(4-((4-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)piperazin-1-yl)methyl)piperidin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, 2,6-dichloro-N-((1s,3s)-3-(6-((4-(4-((4-(1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)piperazin-1-yl)methyl)piperidin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)benzamide, N-((1s,3s)-3-(6-((4-(4-((1-(1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-((1-(1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-4-carbonyl)piperidin-4-yl)methyl)piperazin-1-yl)-2-methylphenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, N-((1s,3s)-3-(6-((4-(4-((1-(3-(2,6-dioxopiperidin-3-yl)-4-oxo-3,4-dihydrobenzo[d][1,2,3]triazin-6-yl)piperidin-4-yl)methyl)piperazin-1-yl)-2-methylphenyl)amino)-9H-purin-9-yl)cyclobutyl)-6-methylpicolinamide, or N-((1s,3s)-3-(6-((4-(4-(7-(4-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)but-2-en-1-yl)-7-azaspiro[3.5]nonan-2-yl)piperazin-1-yl)phenyl)amino)-9H-purin-9-yl)cyclobutyl)-2-phenylacetamide.
12. 12 . A method for preparing a compound according to claim 1 or a pharmaceutically acceptable salt thereof, comprising: a first step of reacting a compound of the Formula 4 below with a derivative of moiety A, comprising an amine group at one end and a protecting group at the other end, and deprotecting the compound to prepare a compound of Formula 5; a second step of reacting the compound of Formula 5 with a derivative of an L1 moiety, comprising a reactive functional group X 2 at one end and a protecting group at the other end, and deprotecting the compound to prepare a compound of Formula 6; and a third step of reacting the compound of Formula 6_with a CRBN binder, comprising a reactive functional group X 3 at one end, Wherein in Formulas 4 to 6 above: X 1 and X 3 are each independently halogen or hydroxy; X 2 is halogen, oxo or hydroxy; the protecting group is tert-butoxycarbonyl; and A′ and L1′ are identical to A and L1, respectively, or in the form of a salt thereof.
13. 13 . The method of claim 12 , wherein the CRBN binder is any one selected from the group consisting of
14. 14 . The method of claim 12 , wherein the first step is performed by reacting a compound, in which X 1 is halogen, by heating at a temperature of 70° C. to 100° C. in a lower alcohol solvent and deprotecting by treating with a strong acid solution in an organic solvent.
15. 15 . The method of claim 12 , wherein the second step is performed by: i) reacting a compound, in which X 2 is hydroxy, with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDCI), hydroxybenzotriazole (HOBt), and N,N-diisopropylethylamine (DIPEA) in an organic solvent at a temperature of 15° C. to 40° C.; ii) reacting a compound, in which X 2 is halogen, in an organic solvent under basic conditions at a temperature of 40° C. to 80° C.; iii) reacting a compound, in which X 2 is oxo, with DIPEA and sodium triacetoxyborohydride (NaBH(OAc) 3 ) at a temperature of 15° C. to 40° C.; or iv) reacting a compound, in which X 2 is oxo, with sodium cyanoborohydride (NaBH(OAc) 3 ) in a lower alcohol solvent in the presence of acetic acid at a temperature of 15° C. to 40° C., and deprotecting by treating with a strong acid solution in an organic solvent.
16. 16 . The method of claim 12 , wherein the third step is performed by: i) reacting a compound, in which X 3 is hydroxy, with EDCL, HOBt, and DIPEA in an organic solvent at a temperature of 15° C. to 40° C.; or ii) reacting a compound, in which X 3 is halogen, with DIPEA in an organic solvent at a temperature of 70° C. to 100° C.
17. 17 . A compound comprising a compound according to claim 1 or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
18. 18 . A pharmaceutical composition for inhibiting or degrading cyclin-dependent kinase 2 (CDK2), cyclin-dependent kinase 9 (CDK9), or both, comprising a compound according to claim 1 or a pharmaceutically acceptable salt thereof as an active ingredient.
19. 19 . A pharmaceutical composition for preventing or treating cancer or human immunodeficiency virus (HIV) infection, comprising a compound according to claim 1 or a pharmaceutically acceptable salt thereof as an active ingredient.
20. 20 . The pharmaceutical composition of claim 19 , wherein the cancer is prostate cancer, lymphoma, glioblastoma, neuroblastoma, ovarian cancer, hepatocellular carcinoma, liver cancer, breast cancer, leukemia, pancreatic cancer, colon cancer, lung cancer, colorectal cancer, or multiple myeloma.

Description

CROSS REFERENCE TO RELATED APPLICATIONS This application is a National Stage of International Application No. PCT/KR2023/012222 filed Aug. 17, 2023, claiming priority based on Korean Patent Application No. 10-2022-0102979 filed Aug. 17, 2022. TECHNICAL FIELD The present invention relates to a group of compounds having activity of inhibiting or degrading cyclin-dependent kinase 2 (CDK2) and/or cyclin-dependent kinase 9 (CDK9), and a method for preparing thereof. The present invention also relates to a pharmaceutical composition comprising these compounds. The present invention relates to a useful method for treating a disease associated with CDK2 or CDK9 using these compounds. In other words, the present invention relates to medicinal use of the compounds according to the present invention in treating or preventing a disease associated with CDK2 or CDK9. BACKGROUND ART Cyclin-dependent kinase (CDK) is a serine/threonine protein kinase that is activated through binding with cyclins. CDK has multiple isoforms, with 21 CDK isoforms being expressed in humans. Each CDK performs distinct roles within cells; however, in terms of functions, the CDKs can be broadly categorized into those involved in cell cycle and those involved in transcription regulation. CDK2 is one of the CDKs that regulate the cell cycle and is activated through binding with cyclin E or cyclin A. The CDK2-cyclin E complex regulates the entry of cells into the S-phase, while the CDK2-cyclin A complex plays a role in regulating DNA synthesis during the S-phase. The activation of uncontrolled CDK2 induces cells to enter the S-phase even when there is a lack of growth factors, leading to chromosomal instability and increased cell proliferation, thereby resulting in the development of cancer. In fact, CDK2 has been reported to be overexpressed in various types of cancer (prostate cancer, B cell lymphoma, glioblastoma; Cell Cycle, 2007, 6: 2982-2989, Future Oncol., 2018, 14: 709-718, Transl. Oncol., 2016, 9: 548-556) and cyclin E1 (ovarian cancer, TNBC, hepatocellular carcinoma, Oncotarget, 2015, 6: 20801-20812, Clin. Cancer Res., 2017, 23: 1862-1874, Oncol. Rep., 2015, 33: 990-996, Gynecol. Oncol., 2018, 151: 327-336, Oncotarget, 2017, 8: 14897-14911). These research findings suggest that therapeutic effects may be expected in cancer types with CDK2 overexpression through selective degradation of CDK2. Furthermore, International Patent Publication No. WO 2006/040036 discloses that CDK2 inhibitors are useful for the treatment of breast cancer, colon cancer, lung cancer, and prostate cancer. CDK9 is one of the CDKs that regulate transcription, and CDK9 binds to cyclin T1, cyclin T2, or cyclin K to form a positive transcription elongation factor (P-TEFb) complex. The P-TEFb complex phosphorylates RNA polymerase II, promoting transcription elongation. CDK9 regulates the expression of the transcription factor Myc (Mol. Cancer Ther., 2019, 18: 1520-32) and the anti-apoptotic protein MCL-1 in cancer (Am. J. Manag. Care, 2018, 24: S356-S365). Therefore, the inhibition of CDK9 was found to suppress cell proliferation in various cancers, including prostate cancer, pancreatic cancer, breast cancer, multiple myeloma, and chronic lymphocytic leukemia (CLL) (Endocrine-Related Cancer, 2016, 23, T211-T226). In addition, since human immunodeficiency virus (HIV) utilizes P-TEFb of the host for virus replication, CDK9 is being used as a candidate target protein for inhibiting HIV replication (Cancer Biol. Ther., 2002, 1: 342-347). Furthermore, International Patent Publication WO 2017/001354 discloses that CDK9 inhibitors may be useful in treating cancer such as acute myeloid leukemia, multiple myeloma, chronic lymphocytic leukemia, diffuse large B-cell lymphoma, Burkitt lymphoma, follicular lymphoma, breast cancer, lung cancer, neuroblastoma, and colorectal cancer, as well as other diseases including cardiovascular diseases, viral diseases, inflammation, and pain. Meanwhile, Proteolysis Targeting Chimera (PROTAC) technology, which degrades target proteins, has recently been actively utilized in drug development (PNAS, 2001, 98(15): 8554-8559, Cell, 2020, 2: 1-3). PROTAC is a novel therapeutic agent that is manufactured by linking inhibitor or binder compounds that specifically bind to certain proteins and ligand compounds that specifically bind to E3 ubiquitin ligase with various types of linkers. Since PROTAC compounds selectively degrade target proteins that cause diseases, the potential for drug resistance is low, and without high binding affinities to the target proteins, sufficient therapeutic effects are achieved through protein degradation. In addition, they can be applied to undruggable targets, which were difficult to inhibit with conventional drugs. Therefore, PROTAC compounds are gaining attention as a novel therapeutic technology. However, not every inhibitor (i.e., binding factor) becomes an effective PROTAC compound by binding to an E3 ubiquitin ligase li