US-20260126189-A1 - Cleanroom System and Vehicle Mounted with Cleanroom System

Abstract

Provided herein is a cleanroom system including a cleanroom having airtightness, an air supply unit that supplies air from an exterior to an interior of the cleanroom, and a safety cabinet including a workspace, a workspace air supply path that supplies air from the interior to the workspace, a workspace exhaust path that exhausts air from the workspace to the exterior, an exhaust fan that is provided in the workspace exhaust path and drives exhaust, and a filter that is provided in the workspace exhaust path and purifies the exhaust.

Inventors

• Masanori Tanaka

Assignees

• GAUDI CLINICAL CO. LTD.

Dates

Publication Date

20260507

Application Date

20240530

Priority Date

20230601

Claims (8)

1. 1 - 7 . (canceled)
2. 8 . A cleanroom system comprising: a cleanroom having airtightness; a room air supply path that supplies air from an exterior to an interior of the cleanroom; and a hazard control cabinet installed inside the cleanroom, the hazard control cabinet including: a workspace; a workspace air supply path that supplies air from the interior of the cleanroom to the workspace; a circulation path that takes in air from the workspace and supplies the air to the workspace again; a workspace exhaust path that is a flow path that has a common portion with the circulation path and branches off midway from the circulation path to reach the exterior, the workspace exhaust path exhausting air from the workspace to the exterior of the cleanroom; an exhaust fan that is provided at the common portion of the circulation path and the workspace exhaust path or a branching position where the circulation path and the workspace exhaust path diverge, and drives circulation in the circulation path and exhaust in the workspace exhaust path; and a filter that is provided in the workspace exhaust path and purifies the exhaust, wherein no other fan is provided in the circulation path between a position where the exhaust fan is provided and the workspace, and the exhaust fan that drives circulation in the circulation path and exhaust in the workspace exhaust path drives total exhaust from the interior of the cleanroom to the exterior, and maintains the interior of the cleanroom at negative pressure.
3. 9 . The cleanroom system according to claim 8 , comprising: a bypass path that communicates with the workspace exhaust path from the interior of the cleanroom without passing through the workspace, wherein the exhaust fan also drives air flowing through the bypass path.
4. 10 . The cleanroom system according to claim 8 , wherein the hazard control cabinet is a safety cabinet, and the workspace is a space in which work is performed on biological objects.
5. 11 . The cleanroom system according to claim 8 , wherein the room air supply path is a natural air supply path that supplies air using negative pressure inside the cleanroom formed by the exhaust fan as a driving force.
6. 12 . The cleanroom system according to claim 8 , wherein the workspace is a space in which work is performed on regenerative medical products manufactured in a cell culture processing facility, and the cleanroom system is installed near treatment locations where the regenerative medical products are used.
7. 13 . The cleanroom system according to claim 12 , wherein the treatment locations are distributed in two or more buildings, and the cleanroom system is installed at a position near the treatment locations in at least two or more buildings.
8. 14 . A vehicle mounted with a cleanroom system, comprising: the cleanroom system according to claim 8 ; and a vehicle on which the cleanroom is mounted, wherein the workspace is a space in which work is performed on regenerative medical products manufactured in a cell culture processing facility, and the vehicle is capable of moving near treatment locations where regenerative medical products are used.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS This application is the United States national phase of International Patent Application No. PCT/JP2024/019928 filed May 30, 2024, and claims priority to Japanese Patent Application No. 2023-091146 filed Jun. 1, 2023, the disclosures of which are hereby incorporated by reference in their entireties. BACKGROUND OF THE INVENTION Field of the Invention The present invention relates to a cleanroom system and a vehicle mounted with the cleanroom system. Description of Related Art In a negative-pressure cleanroom in which an internal pressure is maintained lower than an external pressure, air flows from the exterior to the interior of the cleanroom in a communicating portion with the exterior. Therefore, in a negative-pressure cleanroom, it is possible to reduce or prevent leakage of air containing airborne fine particles such as infectious substances present inside the cleanroom to the exterior of the cleanroom. A cleanroom may be provided with a device such as a safety cabinet that includes a workspace for performing operations on work objects such as infectious substances. In many cases, the safety cabinet controls the supply and exhaust of air from the workspace by itself. Non-Patent Literature 1 is Japanese Industrial Standard JIS for safety cabinets and similar devices. The device is referred to as a biohazard control cabinet, and is classified into Class I, Class II, and Class III according to its basic structure. Class I and Class II are open-type devices with an opening (front opening) in the front wall of the workspace, while Class III is a closed-type device without any opening. Class I devices are generally referred to as draft chambers, which supply air drawn from a front opening to a workspace without purification, and exhaust air from the workspace after purification by a filter. Class II devices are commonly referred to as safety cabinets. Among them, in the type equipped with a circulation path, the air drawn from the front opening is taken into the circulation path. The circulating air is purified by the filter, supplied to the workspace, and exhausted from the workspace, repeating this process. In this process, a portion of the air is purified by a filter and then exhausted to the exterior. In the type without a circulation path, air separately drawn from the exterior is purified by a filter and supplied to the workspace, while the air supplied to the workspace and the air supplied from the front opening are collectively purified by a filter and exhausted to the exterior. Class III devices are generally called isolators, in which air drawn from the exterior is purified by a filter and supplied to a workspace, and the exhaust air from the workspace is purified by a filter and exhausted to the exterior. Although this standard is labeled as “bio”, it is not limited to applications in the biological field, and it has been formulated with consideration for other uses, such as handling other substances such as volatile substances. Patent Literature 1 below describes a negative-pressure cleanroom formed by combining partitions. This cleanroom is used for biological applications, and a safety cabinet is installed therein. In this cleanroom, the air supply/exhaust systems of the cleanroom itself and the safety cabinet are integrated. Specifically, a supply fan supplies air to the cleanroom, and an exhaust fan exhausts air from the cleanroom to the exterior. A local exhaust fan that exhausts air from the safety cabinet to the exterior of the cleanroom is also separately provided. These fans are controlled by a control unit and keep the interior of the cleanroom at negative pressure. Patent Literature 2 below is a literature related to a slightly positive-pressure open-type cleanroom (referred to as a cleanbooth in this literature) that employs an airflow barrier system and is equipped with a safety cabinet and the like. The wall of the cleanroom is provided with a constantly open entrance without a door, and the ceiling is provided with a supply fan. Air is supplied into the cleanroom by a supply fan. In the safety cabinet, a fan provided in the safety cabinet supplies air inside the cleanroom, causes the air to flow into a workspace, and then exhausts the air from the safety cabinet into the cleanroom. The air inside the cleanroom flows in one direction toward the entrance/exit and is exhausted to the exterior of the cleanroom. Patent Literature 3 below describes a technique in which cells collected from a patient are processed and then transplanted to a patient. Cells collected in academia are processed in a cell culture processing facility (referred to as CPF in the literature), returned to academia, and used for transplantation into patients in academia. Cells to be transplanted are treated as pharmaceuticals, and manufacturers are required to perform a series of process controls under CGMP grade in accordance with US laws and regulations (paragraphs 0012 to 00