WO-2026076276-A3 - COMPOSITIONS AND METHODS FOR MODULATION OF 3-HYDROXY-3-METHYLGLUTARYL-COA REDUCTASE (HMGCR) EXPRESSION
WO2026076276A3WO 2026076276 A3WO2026076276 A3WO 2026076276A3WO-2026076276-A3
Abstract
Disclosed herein are compositions and methods for the modulation of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) expression, wherein the compositions include an siRNA duplex or a conjugated siRNA duplex. Also disclosed herein are methods, and compositions for use in methods, of treating age-related macular degeneration (AMD) or hyperlipidemia. The compositions disclosed herein comprise an siRNA duplex that comprises a sense sequence and an antisense sequence, wherein the sense sequence and the antisense sequence are at least partially complementary to each other.
Inventors
- HUBER, HANS
- ACKERMANN, DOUGLAS MICHAEL
- PADERI, JOHN
- WU, KENNETH
Assignees
- OSANNI BIO, INC.
Dates
- Publication Date
- 20260507
- Application Date
- 20251002
- Priority Date
- 20241003