WO-2026092199-A1 - METHOD AND APPARATUS FOR ESTABLISHING THREE-DIMENSIONAL MODEL, AND RADIOTHERAPY SYSTEM

WO2026092199A1WO 2026092199 A1WO2026092199 A1WO 2026092199A1WO-2026092199-A1

Abstract

Provided in the present description are a method and apparatus for establishing a three-dimensional model, and a radiotherapy system. A target region is acquired on the basis of a medical image; the material of each voxel unit in the target region is defined on the basis of a target template in a material template library matched with the target region, wherein a candidate template available for matching in the material template library includes a homogeneous material template and a heterogeneous material template; and a three-dimensional model is established on the basis of the material of each voxel unit in each target region. In this solution, differences in image quality of medical images and variations in tissues and organs of individual patients are taken into consideration. By matching a target template, the material of each voxel unit in each target region is more specifically defined by using a different strategy, so as to establish a three-dimensional model using the more suitable material. The model more closely resembles actual characteristics of tissues and organs of patients, such that treatment plans can more accurately evaluate dose limits for normal tissues and prescribed doses for tumors.

Inventors

TENG, Yi-chiao
ZHONG, Wan-bing
CHEN, JIANG

Assignees

中硼(厦门)医疗器械有限公司

Dates

Publication Date: 20260507
Application Date: 20251020
Priority Date: 20241028

Claims (15)

A method for creating a three-dimensional model, characterized by comprising: Target region is obtained based on medical images; The material of the voxel unit in the target region is defined based on the target template in the material template library that matches the target region. The candidate templates that can be matched in the material template library include homogeneous material templates and heterogeneous material templates. A three-dimensional model is built based on the material of the voxel units in each target region.
The method according to claim 1, characterized in that, defining the material of the voxel unit within the target region based on the target template in the material template library matched with the target region, includes: The candidate templates in the material template library are used as the target templates based on the tissue and organ types and/or image value distribution corresponding to the target region.
The method according to claim 2, characterized in that, based on the image value distribution matching material template library corresponding to the target region, candidate templates are used as target templates, including: The candidate template corresponding to the first reference tissue/organ type in the matching material template library is used as the target template; wherein, the reference range of the image value of the first reference tissue/organ type and the distribution of the image value of the target region satisfy a first preset condition, and the candidate template corresponding to the first reference tissue/organ type is a homogeneous material template or a heterogeneous material template.
The method according to claim 1, characterized in that, defining the material of the voxel unit within the target region based on the target template in the material template library matched with the target region, includes: Based on the relationship between the image value distribution of the target region and the image value reference range of each tissue and organ type, a homogeneous material template or a heterogeneous material template is matched as the target template, or... Based on the OAR information of the target region, a homogeneous material template or a heterogeneous material template is matched as the target template.
The method according to claim 4, characterized in that, defining the material of the voxel unit within the target region based on the target template in the material template library matched with the target region, includes: In response to the image value distribution of the target region and the target reference range satisfying the second preset condition, a heterogeneous material template is matched as the target template, wherein the target reference range is the image value reference range of the tissue organ type corresponding to the target region or the image value reference range of the second reference tissue organ type, and the second reference tissue organ type is determined based on the image value distribution of the target region and the image value reference range of each tissue organ type; In response to the fact that the image value distribution of the target area does not meet the second preset condition with respect to the target reference range, a homogeneous material template is matched as the target template.
According to the method of claim 4, the OAR information of the target area includes whether the target area is an OAR, or whether the target area is a primary OAR; The step of matching a homogeneous material template or a heterogeneous material template as the target template based on the OAR information of the target region includes: In response to the OAR information of the target area, a heterogeneous material template is matched as the target template, or... In response to the OAR information of the target area as the primary OAR, a heterogeneous material template is matched as the target template.
The method according to claim 1, characterized in that, defining the material of the voxel unit within the target region based on the target template in the material template library matched with the target region, includes: Obtain at least two tissue/organ types associated with the image value distribution of the target region; Identify the most radiation-sensitive tissue/organ type among the at least two tissue/organ types; A homogeneous material template matching the type of tissue or organ most sensitive to radiation is used as the target template.
The method according to claim 1, characterized in that the method further comprises constructing heterogeneous material templates in the material template library by at least one of the following methods: Constructed based on the relationship between the density of tissues and organs and imaging values; Constructing a formula based on the relationship between the elemental composition of tissues and organs and image values; Constructed based on key parameters of image values and corresponding densities; Constructed based on key parameters composed of image values and corresponding elements.
A device for creating a three-dimensional model, characterized in that it comprises: The first acquisition unit is used to acquire the target region based on medical images; A definition unit is used to define the material of the voxel unit in the target region based on the target template in the material template library that matches the target region. The candidate templates that can be matched in the material template library include homogeneous material templates and heterogeneous material templates. Establish units, used to build three-dimensional models based on the materials of voxel units in each target region.
The apparatus according to claim 9, wherein the defining unit is further configured to match candidate templates in a material template library as target templates based on the tissue/organ type and/or image value distribution corresponding to the target region.
The apparatus according to claim 9, wherein the defining unit is further configured to match a homogeneous material template or a heterogeneous material template as a target template based on the relationship between the image value distribution of the target region and the image value reference range of each tissue and organ type; or, the defining unit is further configured to match a homogeneous material template or a heterogeneous material template as a target template based on the OAR information of the target region.
The apparatus according to claim 9, characterized in that the apparatus further comprises: The second acquisition unit is used to acquire at least two tissues and organs associated with the image value distribution of the target region; A determining unit is used to determine the most irradiated tissue or organ type among the at least two tissue or organ types; The defining unit is also used to match the homogeneous material template of the tissue or organ type most sensitive to irradiation as the target template.
The apparatus according to claim 9, characterized in that it further comprises a construction unit for constructing heterogeneous material templates in the material template library by at least one of the following methods: Constructed based on the relationship between the density of tissues and organs and imaging values; Constructing a formula based on the relationship between the elemental composition of tissues and organs and image values; Constructed based on key parameters of image values and corresponding densities; Constructed based on key parameters composed of image values and corresponding elements.
A radiotherapy system, characterized in that it comprises: A beam irradiation device used to generate a radiation beam; The treatment plan module is used to generate treatment plans; The control module is used to control the beam irradiation device to generate a radiation beam according to the treatment plan; The treatment planning module includes a three-dimensional model creation device, which comprises: The first acquisition unit is used to acquire the target region based on medical images; A definition unit is used to define the material of the voxel unit in the target region based on the target template in the material template library that matches the target region. The candidate templates that can be matched in the material template library include homogeneous material templates and heterogeneous material templates. Establish units, used to build three-dimensional models based on the materials of voxel units in each target region.
A computer-readable storage medium having a computer program/instructions stored thereon, characterized in that the computer program/instructions, when executed by a processor, implement the steps of the method according to any one of claims 1 to 8.

Description

A method, apparatus, and radiotherapy system for creating a three-dimensional model Technical Field This application relates to the field of radiotherapy technology, and in particular to a method, apparatus and radiotherapy system for creating a three-dimensional model. Background Technology With the development of atomic science, radiotherapy methods such as cobalt-60, linear accelerators, and electron beams have become one of the main means of cancer treatment. However, traditional photon or electron therapy is limited by the physical conditions of radiation itself. While killing tumor cells, it also damages a large number of normal tissues along the beam path. In addition, due to the different sensitivities of tumor cells to radiation, traditional radiotherapy is often less effective for treating more radiation-resistant malignant tumors (such as glioblastoma multiforme and melanoma). To reduce radiation damage to surrounding normal tissues, the concept of targeted therapy in chemotherapy has been applied to radiotherapy. For highly radiation-resistant tumor cells, radiation sources with high relative biological effectiveness (RBE) are being actively developed for radiotherapy, such as proton therapy, heavy ion therapy, and neutron capture therapy. Neutron capture therapy combines the above two concepts; for example, boron neutron capture therapy (BNCT) utilizes the specific accumulation of boron-containing drugs on tumor cells, combined with precise beam modulation, to provide a better cancer treatment option than traditional radiation. Three-dimensional models are widely used in scientific experimental analysis and simulation. For example, in the field of nuclear radiation and protection, to simulate the absorbed dose of the human body under certain radiation conditions to help operators formulate treatment plans, it is often necessary to use computer technology to process medical image data to create accurate three-dimensional models required by Monte Carlo software, and then combine this with Monte Carlo software for simulation calculations. In the field of neutron capture therapy, when creating three-dimensional models required by Monte Carlo software based on medical image data and performing dose calculations and evaluations, it is necessary to define the material information reflected by each voxel unit in the model. The accuracy and precision of the materials determine the reliability of the dose calculation results. During the treatment plan formulation process, a significant amount of time is usually spent defining the materials in various regions. At the same time, the accuracy of medical image acquisition equipment and the quality of the obtained images are limited. The three-dimensional models converted from the parameters of medical image data are often not accurate enough, especially regarding the definition of materials. If there are deviations, it will affect the accuracy of the calculated dose distribution. Treatment plans based on these calculation results will fail to achieve the desired effects and may even cause unexpected damage to normal tissues. Summary of the Invention This specification provides a method, apparatus, and radiotherapy system for creating a three-dimensional model, in order to solve the problem that existing methods for creating three-dimensional models are difficult to reflect the differences in target sites and surgical requirements. To address the aforementioned technical problems, this specification provides a method for establishing a three-dimensional model, comprising: acquiring a target region based on medical images; defining the material of voxel units within the target region based on a target template in a material template library matched by the target region, wherein the candidate templates that can be matched in the material template library include homogeneous material templates and heterogeneous material templates; and establishing a three-dimensional model based on the material of voxel units within each target region. In some embodiments, defining the material of voxel units within the target region based on a target template in a material template library matched with the target region includes: matching candidate templates in a material template library as target templates based on the tissue/organ type and/or image value distribution corresponding to the target region. In some embodiments, defining the material of voxel units within the target region based on a target template in a material template library matched with the target region includes: obtaining the tissue/organ type corresponding to the target region; matching a candidate template corresponding to the tissue/organ type as the target template, wherein the candidate template corresponding to the tissue/organ type is a homogeneous material template or a heterogeneous material template. In some embodiments, defining the material of the voxel unit in the target region based on the ta