WO-2026095824-A1 - A COMBINATION CONSISTING OF RESVERATROL, CURCUMIN, QUERCETIN AND NAD PRECURSOR, A COMPOSITION COMPRISING THE COMBINATION AND USES THEREOF

Abstract

The subject of the invention is a combination consisting of resveratrol, curcumin, quercetin and an NAD precursor. The subject of the invention is also a composition comprising the combination according to the invention. The invention also relates to the use of the combination and the composition according to the invention.

Inventors

• WIETRAK, EWA

Assignees

• NUTROPHARMA SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA

Dates

Publication Date

20260507

Application Date

20251028

Priority Date

20241031

Claims (15)

1. 1. A combination consisting of resveratrol, curcumin, quercetin and NAD precursor.
2. 2. The combination according to the preceding claim, characterized in that the resveratrol is in the form of trans-resveratrol.
3. 3. The combination according to any of the preceding claims, characterized in that the NAD precursor is selected from a nicotinamide dinucleotide (NAD), reduced nicotinamide dinucleotide (NADH), nicotinic acid (NA), nicotinamide riboside (NR), tryptophan (Trp), nicotinamide (N) and nicotinamide mononucleotide (NMN) or a combination thereof.
4. 4. The combination according to any of the preceding claims, characterized in that, it comprises from 10 mg to 200 mg of NAD+ precursor, from 100 mg to 1000 mg of resveratrol, from 10 mg to 200 mg of quercetin, and from 10 mg to 200 mg of curcumin.
5. 5. A composition characterized in that it comprises the combination according to any preceding claim.
6. 6. The composition according to the preceding claim, characterized in that it further comprises an active substance selected from epigallocatechin gallate (EGCG), piperine, trimethylglycine (TMG) and leucine or a combination thereof.
7. 7. The composition according to any of claims 5-6, characterized in that it comprises from 10 mg to 200 mg of epigallocatechin gallate (EGCG) and/or from 0.1 mg to 2 mg piperine and/or from 100 mg to 800 mg trimethylglycine (TMG) and/or from 100 mg to 2000 mg leucine or a combination thereof.
8. 8. The composition according to any of claims 5-7, characterized in that it further comprises at least one food and/or pharmaceutically acceptable excipient.
9. 9. The composition according to any of claims 5-8, characterized in that it is in the form of a powder, granulate, micropellet, microtablet, capsule, tablet, solution, food, dietary supplement and/or food additive.
10. 10. Use of the combination according to any of claims 1-4 in nutritional support.
11. 11. The use according to claim 10, characterized in that the nutritional support is a dietary support.
12. 12. The use according to any of claims 10-11 , characterized in that the nutritional support is support of healthy aging.
13. 13. Use of the composition according to any of claims 5-9 in nutritional support.
14. 14. The use according to claim 13, characterized in that the nutritional support is a dietary support.
15. 15. Use according to any of claims 13-14, characterized in that the nutritional support is support of healthy aging.

Description

A COMBINATION CONSISTING OF RESVERATROL, CURCUMIN, QUERCETIN AND NAD PRECURSOR, A COMPOSITION COMPRISING THE COMBINATION AND USES THEREOF The subject of the invention is a combination of resveratrol, curcumin, quercetin and a NAD precursor. The subject of the invention is also a composition comprising the combination according to the invention. The subject of the invention is also the use of the combination according to the invention or the composition according to the invention. The invention will find application in broadly understood nutritional support, and in particular in supporting diet and/or in supporting healthy aging. SIRTuin diets (hereinafter also referred to as SIRT diets) are gaining increasing interest among both patients and scientists. SIRT diets, by design, utilize foods rich in so- called sirtuin activators (also referred to in the literature as sirtuin modulators and/or regulators). Importantly, however, SIRT diets emphasize the inclusion of appropriate foods in the diet, not the elimination of others. Furthermore, SIRT diets move away from severe restriction of calories or meal frequency (so-called fasting). Thanks to this approach, SIRT diets are expected to be easier to implement and have long-term acceptance compared to most currently available restrictive diets. Despite their advantages, SIRT diets also have their limitations. Firstly, there is a wide range of foods rich in sirtuin activators. These include grapes rich in resveratrol, citrus fruits rich in naringin, cucumbers, and fisetin- rich blueberries. Selecting the most beneficial substances and their quantities from a large catalog of foods from different climates presents a significant challenge in standardizing SIRT diets and maximizing their effectiveness. Secondly, foods available and inexpensive in certain climates (such as citrus fruits and grapes in the Mediterranean) may be beyond the reach of the daily diet in other latitudes. Furthermore, each sirtuin activator — regardless of its advantages — has its own individual limitations and drawbacks. For example, resveratrol — despite its high potential for sirtuin activation — presents formulation challenges, such as low solubility and bioavailability. Therefore, intensive research and implementation work is currently underway on standardized SIRT dietary supplements containing ingredients that are more optimal in terms of active substances, quantity, and acceptability (including economic). These products must be easily digestible and have favorable storage life (e.g., powders, tablets, and capsules). At the same time, their optimization cannot come at the expense of the solubility, digestibility, and bioavailability of the active substances and nutrients they contain. An example of a commercially available Sirt diet supplement is the Italian product Yes, Sirt. The supplement is sold in capsule form, containing many ingredients, but in small quantities. These include mate, garcinia, green tea, cocoa, olive (fruit), fenugreek, resveratrol, grape extract, matcha (powder), and nucleotides. In addition to weight loss, an emerging health and cultural need is healthy aging. It's worth emphasizing that, contrary to popular belief, aging affects everyone. This is because everyone, regardless of age, is exposed to adverse external factors (e.g., UV radiation on the skin) and internal factors (e.g., oxidative stress). Healthy aging, unlike anti - aging, does not involve the currently popular drastic prevention, treatment, or reversal of aging. Instead, healthy aging focuses on accepting this natural phenomenon and supporting health maintenance and optimizing, among other things, appearance, weight, and fitness as we age. Furthermore, sirtuins modulate gene expression. It turns out that sirtuin -regulated genes are responsible for, among other things, aging processes (DNA repair, tissue regeneration, signaling between neurons) and metabolic processes (control of metabolism, processes related to glucose metabolism - gluconeogenesis, glycolysis, maintaining optimal glucose and insulin levels). The SIRT diet is also rich in antioxidants and promotes the production of antioxidant substances in the body. Therefore, its use in healthy aging would be very beneficial. As with the weight-loss effects of the SIRT diet, selecting the most beneficial antioxidants and their quantities from a large catalog of foods presents a significant challenge in standardizing SIRT diets, maximizing their effectiveness and economic availability. Furthermore, the catalog of foods and antioxidant substances does not necessarily overlap with the catalog of foods and substances that support weight loss, further complicating the selection of a universal composition combining weight-loss and anti-aging benefits. On the other hand, recent research indicates that excessive antioxidant use can lead to the unfavorable phenomenon of reductive stress. Therefore, drastic antioxidant intervention can lead to the count