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WO-2026096082-A1 - PREFILLED RAPID BOLUS SYRINGE

WO2026096082A1WO 2026096082 A1WO2026096082 A1WO 2026096082A1WO-2026096082-A1

Abstract

A syringe may be pre-filled with fluid and connected to a rapid infusion attachment to deliver a rapid bolus of fluid to a patient. The rapid infusion attachment may comprise a spring that, when compressed, provides a spring force to the plunger of the syringe. The device comprising the syringe and the rapid infusion attachment may be shipped and stored such that the syringe is pre-filled and the spring is pre-loaded, or compressed. The device may also be shipped and stored with the spring uncompressed, and a clinician or other user may compress the spring prior to attaching the device to an IV set or other fluid pathway. The device may further comprise a mechanism that allow the clinician to control the fluid flow. The device may also further comprise a locking mechanism that can be released when the fluid in the syringe is to be injected.

Inventors

  • CALLAHAN, RYAN
  • SHEVGOOR, SIDDARTH K.
  • MASON, GENE E.
  • NALLURI, Likhith

Assignees

  • CAREFUSION 303, INC.

Dates

Publication Date
20260507
Application Date
20250909
Priority Date
20241104

Claims (20)

  1. 1. A device for rapid fluid delivery, the device comprising: a pre-filled syringe for providing an infusion, the syringe comprising: a syringe barrel for holding a fluid; and a syringe plunger connected to a proximal end of the barrel; and a rapid infusion attachment, wherein the rapid infusion attachment provides increased pressure to drive an infusion, the rapid infusion attachment comprising: an attachment plunger connected to the syringe plunger by a spring; a housing that sheaths a portion of the attachment plunger; and an activation mechanism that controls flow of the fluid from the syringe.
  2. 2. The device of Claim 1, wherein the attachment plunger comprises a base portion and a hollow channel portion, wherein the hollow channel portion houses the spring.
  3. 3. The device of Claim 2, wherein the attachment plunger slides to sheath the hollow channel portion within the housing.
  4. 4. The device of Claim 3, wherein the spring is attached to a proximal end of the syringe plunger and the base portion of the hollow channel of the attachment plunger, and wherein when the hollow channel portion is sheathed within the housing, the spring is in a compressed position, and wherein the spring provides an injection force to the syringe plunger when the spring is in the compressed position.
  5. 5. The device of Claim 4, wherein the hollow channel portion is sheathed within the housing, compressing the spring, before being packaged.
  6. 6. The device of Claim 4, wherein the hollow channel portion of the attachment plunger comprises exterior threads and the housing comprises interior threads that interact with the exterior threads of the hollow channel portion, and wherein the attachment plunger twists to sheath the hollow channel portion within the housing. - 16 - #4393521vl Docket No. : P-28122. WOO 1/ B7305.11106WO01 PATENT
  7. 7. The device of Claim 4, wherein the attachment plunger comprises a protruding flange at a distal end of the hollow channel portion and wherein the housing comprises interior grooves that catch the protruding flange of the attachment plunger such that when a compression force is applied to a proximal end of the attachment plunger, the hollow channel portion is sheathed within the housing and the protruding flange interacts with the interior grooves to keep the attachment plunger in its sheathed position.
  8. 8. The device of Claim 1, wherein the activation mechanism is attached to a needle end of the syringe and wherein the activation mechanism stops the fluid from flowing out of the syringe when closed and allows the fluid to flow out of the syringe when open.
  9. 9. The device of Claim 1, wherein a distal end of the syringe facilitates attachment of the device to a venous access pathway.
  10. 10. The device of Claim 1, wherein the syringe barrel is pre-filled with sterile saline or other fluid for a rapid fluid injection.
  11. 11. The device of Claim 1, wherein the housing removably clips to the pre-filled syringe.
  12. 12. A device for rapid fluid delivery, the device comprising: a pre-filled syringe for providing an infusion, the syringe comprising: a syringe barrel with a proximal end and a distal end, wherein the barrel is filled with a fluid; and a syringe plunger with a gasket end and a free end, wherein the gasket end is located within the barrel; and a device plunger with a base portion and an elongate core portion, wherein the elongate core portion comprises a hollow chamber configured to receive the syringe plunger; a housing with a proximal end and a distal end, wherein the distal end of the housing is attached to the proximal end of the syringe barrel, wherein the housing is configured to receive the elongate core portion of the device plunger; and - 17 - #4393521vl Docket No. : P-28122. WOO 1/ B7305.11106WO01 PATENT a pre-compressed spring attached to the free end of the syringe plunger and to the device plunger, wherein the pre-compressed spring provides an injection force to the syringe plunger.
  13. 13. The device of Claim 12, further comprising a flow regulating device attached to a tip of the syringe barrel, wherein the flow regulating device controls fluid flow from the syringe barrel.
  14. 14. The device of Claim 13, wherein the flow regulating device comprises a valve mechanism configured to open and close a fluid pathway.
  15. 15. The device of Claim 14, wherein opening the fluid pathway permits the fluid to be pushed out of the syringe barrel as the spring decompresses.
  16. 16. The device of Claim 14, wherein the valve mechanism is electronic and programmable such that the valve mechanism opens and closes the fluid pathway on a timer to administer the fluid at a predetermined rate.
  17. 17. The device of Claim 12, wherein the pre-filled syringe is configured to be inserted into an IV system or a patient.
  18. 18. A device for automatic syringe dispensing, the device comprising: a syringe barrel having a tip end and a base end; a spring located within the syringe barrel and attached to the base end of the syringe barrel; a locking mechanism located within the syringe barrel and adjacent to the spring; and a plunger located within the syringe barrel and adjacent to the locking mechanism; wherein the locking mechanism prohibits movement of the plunger when active and permits movement of the plunger when released. - 18 - #4393521vl Docket No. : P-28122. WOO 1/ B7305.11106WO01 PATENT
  19. 19. The device of Claim 18, wherein the syringe barrel is filled with a fluid, and wherein the fluid is pushed out of the syringe barrel by the spring when the locking mechanism is released.
  20. 20. The device of Claim 19, further comprising a flow regulator attached to the tip end of the syringe, wherein the flow regulator is configurable to infuse the fluid at a determined rate. - 19 - #4393521vl

Description

Docket No. : P-28122. WOO 1/ B7305.11106WO01 PATENT PREFILLED RAPID BOLUS SYRINGE CROSS REFERENCE TO RELATED APPLICATION [0001] This application claims the benefit of priority from U.S. Patent Application No. 18/936,620, entitled “PREFILLED RAPID BOLUS SYRINGE,” filed on November 4, 2024, the entirety of which is incorporated herein by reference. FIELD OF THE INVENTION [0002] The present disclosure generally relates to syringes, and, in particular, to rapid fluid delivery. BACKGROUND [0003] Medical treatments often include the infusion of a medical fluid (e.g., a saline solution or a liquid medication) to patients using an intravenous (IV) catheter that is connected though an arrangement of flexible tubing and fittings, commonly referred to as an “IV set,” to a source of fluid, for example, an IV bag. In cases of trauma with large loss of blood or sepsis, the initial response from healthcare providers is often to provide rapid fluid resuscitation in order to restore blood pressure. This is often achieved by a gravity IV set. SUMMARY [0004] Gravity sets can take significant time to set up, and gravity flow rate is often insufficient. Dedicated rapid infusers are not portable and are only available in high end medical centers. [0005] One or more embodiments of the present disclosure are directed to a device for rapid fluid delivery comprising a pre-filled syringe for providing an infusion, the syringe comprising a syringe barrel for holding a fluid, and a syringe plunger connected to a proximal end of the barrel, and a rapid infusion attachment, wherein the rapid infusion attachment provides increased pressure to drive an infusion, the rapid infusion attachment comprising an attachment plunger connected to the syringe plunger by a spring, and a housing that sheaths a portion of the attachment plunger, and an activation mechanism that controls flow of the fluid from the syringe. [0006] In some embodiments, the attachment plunger comprises a base portion and a hollow channel portion, wherein the hollow channel portion houses the spring. - 1 - #4393521vl Docket No. : P-28122. WOO 1/ B7305.11106WO01 PATENT [0007] In some embodiments, the attachment plunger slides to sheath the hollow channel portion within the housing. [0008] In some embodiments, the spring is attached to a proximal end of the syringe plunger and the base portion of the hollow channel of the attachment plunger, and when the hollow channel portion is sheathed within the housing, the spring is in a compressed position, and the spring provides an injection force to the syringe plunger when the spring is in the compressed position. [0009] In some embodiments, the hollow channel portion is sheathed within the housing, compressing the spring, before being packaged. [0010] In some embodiments, the hollow channel portion of the attachment plunger comprises exterior threads and the housing comprises interior threads that interact with the exterior threads of the hollow channel portion, and the attachment plunger twists to sheath the hollow channel portion within the housing. [0011] In some embodiments, the attachment plunger comprises a protruding flange at a distal end of the hollow channel portion and the housing comprises interior grooves that catch the protruding flange of the attachment plunger such that when a compression force is applied to a proximal end of the attachment plunger, the hollow channel portion is sheathed within the housing and the protruding flange interacts with the interior grooves to keep the attachment plunger in its sheathed position. [0012] In some embodiments, the activation mechanism is attached to a needle end of the syringe and the activation mechanism stops the fluid from flowing out of the syringe when closed and allows the fluid to flow out of the syringe when open. [0013] In some embodiments, a distal end of the syringe facilitates attachment of the device to a venous access pathway. [0014] In some embodiments, the syringe barrel is pre-filled with sterile saline or other fluid for a rapid fluid injection. [0015] In some embodiments, the attachment housing removably clips to the pre-filled syringe. [0016] One or more embodiments of the present disclosure are directed to a device for rapid fluid delivery, comprising a pre-filled syringe for providing an infusion, where the syringe comprises a syringe barrel with a proximal end and a distal end, wherein the barrel is filled with a fluid, and a syringe plunger with a gasket end and a free end, wherein the gasket end is located within the barrel, and a device plunger with a base portion and an elongate core portion, wherein the elongate core portion comprises a hollow chamber configured to receive - 2 - #4393521vl Docket No. : P-28122. WOO 1/ B7305.11106WO01 PATENT the syringe plunger, a housing with a proximal end and a distal end, wherein the distal end of the housing is attached to the proximal end of the syringe barrel, wherein the housing is configured to receive