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WO-2026096454-A1 - FORMULATIONS COMPRISING INOSITOL, SILICATES, AND OPTIONALLY AMINO ACIDS WITH IMPROVED SOLUBILITY AND METHODS OF MAKING THE SAME

WO2026096454A1WO 2026096454 A1WO2026096454 A1WO 2026096454A1WO-2026096454-A1

Abstract

Provided herein are compositions comprising a silicate, inositol, and optionally an amino acid, which have improved solubility and/or are crystalline. Also provided are methods of making the disclosed compositions, as well as methods of making beverages comprising the disclosed compositions.

Inventors

  • CESARIO, CARA

Assignees

  • Nutrition21, LLC

Dates

Publication Date
20260507
Application Date
20251028
Priority Date
20241028

Claims (20)

  1. CLAIMS
  2. We claim:
  3. 1. A composition comprising:
  4. arginine;
  5. a silicate; and
  6. inositol;
  7. wherein the solubility of the composition in water is at least 5 wt% at 20 °C.
  8. 2. A composition comprising:
  9. a silicate; and
  10. inositol;
  11. wherein the solubility of the composition in water is at least 5 wt% at 20 °C.
  12. 3. The composition of claim 2, further comprising an amino acid.
  13. 4. The composition of claim 3, wherein the amino acid is arginine.
  14. 5. The composition of any one of claims 1-4, wherein the solubility of the composition in water is at least 20 wt% at 20 °C.
  15. 6. The composition of any one of claims 1-5, wherein the solubility of the composition in water is at least 30 wt% at 20 °C.
  16. 7. The composition of any one of claims 1-6, wherein the solubility of the composition in water is at least 40 wt% at 20 °C.
  17. 8. The composition of any one of claims 1-7, wherein the solubility of the composition in water is at least 50 wt% at 20 °C.
  18. 9. The composition of any one of claims 1-8, wherein the composition further comprises a hydroxide source. 10. The composition of claim 9, wherein the hydroxide source comprises sodium hydroxide or potassium hydroxide.
  19. 11. The composition of claim 9 or 10, wherein the hydroxide source comprises sodium hydroxide.
  20. 12. The composition of any one of claims 9-11, wherein the hydroxide source is present in a molar ratio from about 0.1:1 to about 0.5:1 relative to the arginine.

Description

FORMULATIONS COMPRISING INOSITOL, SILICATES, AND OPTIONALLY AMINO ACIDS WITH IMPROVED SOLUBILITY AND METHODS OF MAKING THE SAME CROSS-REFERENCE TO RELATED APPLICATIONS This application claims priority to U. S. Provisional Application No. 63/712,812 filed October 28, 2024, the contents of which is incorporated by reference herein in its entirety. BACKGROUND OF THE INVENTION Compositions comprising silicates, inositol, and optionally amino acids can be used to provide bioavailable sources of the component ingredients. Such compositions have many health and sports nutrition benefits. In addition to increasing nitric oxide (NO) levels, and therefore blood flow, such compositions can benefit recovery, muscle damage, energy, muscle pump, cognitive function, wound healing, and bone health. Additionally, such compositions can be useful for improving the appearance of skin, hair, and nails. However, these compositions typically exhibit poor water solubility, which limits their utility in nutritional beverages. Accordingly, there is a need for alternative compositions having improved water solubility. SUMMARY In certain aspects, provided herein are compositions comprising a silicate and inositol, wherein the solubility of the composition in water is at least 5 wt% at about 20 °C. The compositions may further comprise an amino acid, such as arginine. In further aspects, provided herein are compositions comprising arginine, a silicate, and inositol, wherein the solubility of the composition in water is at least 5 wt% at about 20 °C. In yet further aspects, provided herein are freeze dried compositions comprising a silicate and inositol, wherein the solubility of the composition in water is at least 5 wt% at about 20 °C. The compositions may further comprise an amino acid, such as arginine. In still further aspects, provided herein are freeze dried compositions comprising arginine, a silicate, and inositol, wherein the solubility of the composition in water is at least 5 wt% at about 20 °C. In certain embodiments, the compositions of the disclosure further comprise a hydroxide source, such as sodium hydroxide or potassium hydroxide. In certain aspects, provided herein are methods of making the disclosed compositions comprising: combining the silicate, the inositol, and when present, the arginine in water to form a first mixture; optionally adding a hydroxide source to the first mixture to afford a second mixture; and freeze drying the first mixture or the second mixture to afford the composition. In further aspects, provided herein are methods of making the disclosed compositions comprising: optionally, an amino acid; a silicate; and inositol; wherein the solubility of the composition in water is at least 5 wt% at about 20 °C; the method comprising: combining the silicate, the inositol, and when present, the arginine in water to form a first mixture; optionally adding a hydroxide source to the first mixture to afford a second mixture; and freeze drying the first mixture or the second mixture to afford the composition. In yet further aspects, provided herein are methods of making a beverage comprising a composition comprising: optionally, an amino acid; a silicate; and inositol; wherein the solubility of the composition in water is at least 5 wt% at about 20 °C; the method comprising: combining the silicate, the inositol, and when present, the amino acid in water to form a first mixture; optionally adding a hydroxide source to the first mixture to afford a second mixture; freeze drying the first mixture or the second mixture to afford the composition; and dissolving the composition in water to afford the beverage. In still further aspects, provided herein are beverages prepared by disclosed methods. In certain aspects, provided herein are compositions comprising: arginine; a silicate; and inositol, wherein the composition has an X-ray powder diffraction (XRPD) pattern comprising 2-Theta peaks at 18.4 ±0.1°, 19.2 ±0.1°, and 27.5 ±0.1°. BRIEF DESCRIPTION OF THE FIGURES FIG. 1 is a Thermogravimetric Analysis (TGA) thermogram of Composition 1. FIG. 2 is a Differential Scanning Calorimetry (DSC) thermogram of Composition 1. FIG. 3 is a TGA thermogram of Composition 2. FIG. 4 is a DSC thermogram of Composition 2. FIG. 5 is a TGA thermogram of Composition 3. FIG. 6 is a DSC thermogram of Composition 3. FIG. 7 is a TGA thermogram of Composition 4. FIG. 8 is a DSC thermogram of Composition 4. FIG. 9 is a TGA thermogram of Composition 5. FIG. 10 is a DSC thermogram of Composition 5. FIG. 11 is an XRPD pattern of Composition 1. FIG. 12 is an XRPD pattern of Composition 2. FIG. 13 is an XRPD pattern of Composition 3. FIG. 14 depicts scanning electron microscopy (SEM) images of Composition 1. FIG. 15 depicts SEM images of Composition 2. FIG. 16 depicts SEM images of Composition 3. FIG. 17 depicts SEM images of Composition 4. FIG. 18 depicts SEM images of Composition 5. FIG. 19 depicts SEM images of Composition 8. FIG. 20 depi